Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization

Objectives. The purpose of this study was to determine whether there is a dose-response relationship between body mass index (BMI) and all-cause mortality in patients after coronary revascularization. Methods. The MIMIC-III database (version 1.4) was used as the sample population. For variables with...

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Autores principales:	Chengzhuo Li, Didi Han, Fengshuo Xu, Shuai Zheng, Luming Zhang, Zichen Wang, Rui Yang, Haiyan Yin, Jun Lyu
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi-Wiley 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/15f0cab4c24c4cd596302175397a6f08
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spelling	oai:doaj.org-article:15f0cab4c24c4cd596302175397a6f082021-11-29T00:56:25ZObesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization1540-818310.1155/2021/3867735https://doaj.org/article/15f0cab4c24c4cd596302175397a6f082021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/3867735https://doaj.org/toc/1540-8183Objectives. The purpose of this study was to determine whether there is a dose-response relationship between body mass index (BMI) and all-cause mortality in patients after coronary revascularization. Methods. The MIMIC-III database (version 1.4) was used as the sample population. For variables with less than 10% of values missing, we used the mice package of R software for multiple imputations. Cox regression was used to determine the risk factors of all-cause mortality in patients. RCSs were used to observe the relationship between BMI and all-cause mortality. Additional subgroup and sensitivity analyses were also performed to explore whether the conclusion can be applied to specific groups. Results. Both univariate and multivariate Cox models indicated that the mortality risk was lower for overweight patients than for normal-weight patients (P<0.05). In RCS models, BMI had a U-shaped relationship with all-cause mortality of patients after coronary artery bypass grafting (CABG) (P for nonlinearity = 0.0028). There was a weak U-shaped relationship between BMI and all-cause mortality after percutaneous coronary intervention (PCI), but the nonlinear relationship between these two parameters was not significant (P for nonlinearity = 0.1756). Conclusions. The obesity paradox does exist in patients treated with CABG and PCI. RCS analysis indicated that there was a U-shaped relationship between BMI and all-cause mortality in patients after CABG. After sex stratification, the relationship between BMI and all-cause mortality in male patients who received PCI was L-shaped, while the nonlinear relationship among females was not significant.Chengzhuo LiDidi HanFengshuo XuShuai ZhengLuming ZhangZichen WangRui YangHaiyan YinJun LyuHindawi-WileyarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of Interventional Cardiology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Chengzhuo Li Didi Han Fengshuo Xu Shuai Zheng Luming Zhang Zichen Wang Rui Yang Haiyan Yin Jun Lyu Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization
description	Objectives. The purpose of this study was to determine whether there is a dose-response relationship between body mass index (BMI) and all-cause mortality in patients after coronary revascularization. Methods. The MIMIC-III database (version 1.4) was used as the sample population. For variables with less than 10% of values missing, we used the mice package of R software for multiple imputations. Cox regression was used to determine the risk factors of all-cause mortality in patients. RCSs were used to observe the relationship between BMI and all-cause mortality. Additional subgroup and sensitivity analyses were also performed to explore whether the conclusion can be applied to specific groups. Results. Both univariate and multivariate Cox models indicated that the mortality risk was lower for overweight patients than for normal-weight patients (P<0.05). In RCS models, BMI had a U-shaped relationship with all-cause mortality of patients after coronary artery bypass grafting (CABG) (P for nonlinearity = 0.0028). There was a weak U-shaped relationship between BMI and all-cause mortality after percutaneous coronary intervention (PCI), but the nonlinear relationship between these two parameters was not significant (P for nonlinearity = 0.1756). Conclusions. The obesity paradox does exist in patients treated with CABG and PCI. RCS analysis indicated that there was a U-shaped relationship between BMI and all-cause mortality in patients after CABG. After sex stratification, the relationship between BMI and all-cause mortality in male patients who received PCI was L-shaped, while the nonlinear relationship among females was not significant.
format	article
author	Chengzhuo Li Didi Han Fengshuo Xu Shuai Zheng Luming Zhang Zichen Wang Rui Yang Haiyan Yin Jun Lyu
author_facet	Chengzhuo Li Didi Han Fengshuo Xu Shuai Zheng Luming Zhang Zichen Wang Rui Yang Haiyan Yin Jun Lyu
author_sort	Chengzhuo Li
title	Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization
title_short	Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization
title_full	Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization
title_fullStr	Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization
title_full_unstemmed	Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization
title_sort	obesity paradox of all-cause mortality in 4,133 patients treated with coronary revascularization
publisher	Hindawi-Wiley
publishDate	2021
url	https://doaj.org/article/15f0cab4c24c4cd596302175397a6f08
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Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization

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