Epauletted fruit bats display exceptionally high infections with a Hepatocystis species complex in South Sudan

Abstract Hepatocystis parasites are closely related to mammalian Plasmodium species, the causative agents of malaria. Despite the close phylogenetic relationship, Hepatocystis parasites lack the intermittent erythrocytic replication cycles, the signature and exclusive cause of malaria-related morbid...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Juliane Schaer, Susan L. Perkins, Imran Ejotre, Megan E. Vodzak, Kai Matuschewski, DeeAnn M. Reeder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15f1feb28f9447cbb02654d7b664da92
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:15f1feb28f9447cbb02654d7b664da92
record_format	dspace
spelling	oai:doaj.org-article:15f1feb28f9447cbb02654d7b664da922021-12-02T15:05:12ZEpauletted fruit bats display exceptionally high infections with a Hepatocystis species complex in South Sudan10.1038/s41598-017-07093-z2045-2322https://doaj.org/article/15f1feb28f9447cbb02654d7b664da922017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07093-zhttps://doaj.org/toc/2045-2322Abstract Hepatocystis parasites are closely related to mammalian Plasmodium species, the causative agents of malaria. Despite the close phylogenetic relationship, Hepatocystis parasites lack the intermittent erythrocytic replication cycles, the signature and exclusive cause of malaria-related morbidity and mortality. Hepatocystis population expansion in the mammalian host is thought to be restricted to the pre-erythrocytic liver phase. Complete differentiation of first generation blood stages into sexual stages for subsequent vector transmission indicates alternative parasite/host co-evolution. In this study, we identified a region of exceptionally high prevalence of Hepatocystis infections in Old World fruit bats in South Sudan. Investigations over the course of five consecutive surveys revealed an average of 93 percent prevalence in four genera of African epauletted fruit bats. We observed a clear seasonal pattern and tolerance of high parasite loads in these bats. Phylogenetic analyses revealed several cryptic Hepatocystis parasite species and, in contrast to mammalian Plasmodium parasites, neither host specificity nor strong geographical patterns were evident. Together, our study provides evidence for Pan-African distribution and local high endemicity of a Hepatocystis species complex in Pteropodidae.Juliane SchaerSusan L. PerkinsImran EjotreMegan E. VodzakKai MatuschewskiDeeAnn M. ReederNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juliane Schaer Susan L. Perkins Imran Ejotre Megan E. Vodzak Kai Matuschewski DeeAnn M. Reeder Epauletted fruit bats display exceptionally high infections with a Hepatocystis species complex in South Sudan
description	Abstract Hepatocystis parasites are closely related to mammalian Plasmodium species, the causative agents of malaria. Despite the close phylogenetic relationship, Hepatocystis parasites lack the intermittent erythrocytic replication cycles, the signature and exclusive cause of malaria-related morbidity and mortality. Hepatocystis population expansion in the mammalian host is thought to be restricted to the pre-erythrocytic liver phase. Complete differentiation of first generation blood stages into sexual stages for subsequent vector transmission indicates alternative parasite/host co-evolution. In this study, we identified a region of exceptionally high prevalence of Hepatocystis infections in Old World fruit bats in South Sudan. Investigations over the course of five consecutive surveys revealed an average of 93 percent prevalence in four genera of African epauletted fruit bats. We observed a clear seasonal pattern and tolerance of high parasite loads in these bats. Phylogenetic analyses revealed several cryptic Hepatocystis parasite species and, in contrast to mammalian Plasmodium parasites, neither host specificity nor strong geographical patterns were evident. Together, our study provides evidence for Pan-African distribution and local high endemicity of a Hepatocystis species complex in Pteropodidae.
format	article
author	Juliane Schaer Susan L. Perkins Imran Ejotre Megan E. Vodzak Kai Matuschewski DeeAnn M. Reeder
author_facet	Juliane Schaer Susan L. Perkins Imran Ejotre Megan E. Vodzak Kai Matuschewski DeeAnn M. Reeder
author_sort	Juliane Schaer
title	Epauletted fruit bats display exceptionally high infections with a Hepatocystis species complex in South Sudan
title_short	Epauletted fruit bats display exceptionally high infections with a Hepatocystis species complex in South Sudan
title_full	Epauletted fruit bats display exceptionally high infections with a Hepatocystis species complex in South Sudan
title_fullStr	Epauletted fruit bats display exceptionally high infections with a Hepatocystis species complex in South Sudan
title_full_unstemmed	Epauletted fruit bats display exceptionally high infections with a Hepatocystis species complex in South Sudan
title_sort	epauletted fruit bats display exceptionally high infections with a hepatocystis species complex in south sudan
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/15f1feb28f9447cbb02654d7b664da92
work_keys_str_mv	AT julianeschaer epaulettedfruitbatsdisplayexceptionallyhighinfectionswithahepatocystisspeciescomplexinsouthsudan AT susanlperkins epaulettedfruitbatsdisplayexceptionallyhighinfectionswithahepatocystisspeciescomplexinsouthsudan AT imranejotre epaulettedfruitbatsdisplayexceptionallyhighinfectionswithahepatocystisspeciescomplexinsouthsudan AT meganevodzak epaulettedfruitbatsdisplayexceptionallyhighinfectionswithahepatocystisspeciescomplexinsouthsudan AT kaimatuschewski epaulettedfruitbatsdisplayexceptionallyhighinfectionswithahepatocystisspeciescomplexinsouthsudan AT deeannmreeder epaulettedfruitbatsdisplayexceptionallyhighinfectionswithahepatocystisspeciescomplexinsouthsudan
_version_	1718388875414470656

Epauletted fruit bats display exceptionally high infections with a Hepatocystis species complex in South Sudan

Ejemplares similares