Differential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegans

Abstract The metabolic and endocrine functions of adipose tissue and the ability of organisms to cope with cellular stress have a direct impact on physiological ageing and the aetiology of various diseases such as obesity-related pathologies and cancer. The endocrine effects of adipose tissue are me...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Emmanouil Kyriakakis, Nikolaos Charmpilas, Nektarios Tavernarakis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15f33101a3424361ae6e8bfdbd5724b0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:15f33101a3424361ae6e8bfdbd5724b0
record_format	dspace
spelling	oai:doaj.org-article:15f33101a3424361ae6e8bfdbd5724b02021-12-02T15:04:55ZDifferential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegans10.1038/s41598-017-05276-22045-2322https://doaj.org/article/15f33101a3424361ae6e8bfdbd5724b02017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05276-2https://doaj.org/toc/2045-2322Abstract The metabolic and endocrine functions of adipose tissue and the ability of organisms to cope with cellular stress have a direct impact on physiological ageing and the aetiology of various diseases such as obesity-related pathologies and cancer. The endocrine effects of adipose tissue are mediated by secreted adipokines, which modulate metabolic processes and influence related maladies. Although a plethora of molecules and signaling pathways associate ageing with proteotoxic stress and cellular metabolism, our understanding of how these pathways interconnect to coordinate organismal physiology remains limited. We dissected the mechanisms linking adiponectin signalling pathways and endoplasmic reticulum (ER) proteotoxic stress responses that individually or synergistically affect longevity in C. elegans. Animals deficient for the adiponectin receptor PAQR-1 respond to ER stress, by rapidly activating the canonical ER unfolded protein response (UPRER) pathway, which is primed in these animals under physiological conditions by specific stress defence transcription factors. PAQR-1 loss enhances survival and promotes longevity under ER stress and reduced insulin/IGF-1 signalling. PAQR-1 engages UPRER, autophagy and lipase activity to modulate lipid metabolism during ageing. Our findings demonstrate that moderating adiponectin receptor -1 activity extends lifespan under stress, and directly implicate adiponectin signalling as a coupler between proteostasis and lipid metabolism during ageing.Emmanouil KyriakakisNikolaos CharmpilasNektarios TavernarakisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emmanouil Kyriakakis Nikolaos Charmpilas Nektarios Tavernarakis Differential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegans
description	Abstract The metabolic and endocrine functions of adipose tissue and the ability of organisms to cope with cellular stress have a direct impact on physiological ageing and the aetiology of various diseases such as obesity-related pathologies and cancer. The endocrine effects of adipose tissue are mediated by secreted adipokines, which modulate metabolic processes and influence related maladies. Although a plethora of molecules and signaling pathways associate ageing with proteotoxic stress and cellular metabolism, our understanding of how these pathways interconnect to coordinate organismal physiology remains limited. We dissected the mechanisms linking adiponectin signalling pathways and endoplasmic reticulum (ER) proteotoxic stress responses that individually or synergistically affect longevity in C. elegans. Animals deficient for the adiponectin receptor PAQR-1 respond to ER stress, by rapidly activating the canonical ER unfolded protein response (UPRER) pathway, which is primed in these animals under physiological conditions by specific stress defence transcription factors. PAQR-1 loss enhances survival and promotes longevity under ER stress and reduced insulin/IGF-1 signalling. PAQR-1 engages UPRER, autophagy and lipase activity to modulate lipid metabolism during ageing. Our findings demonstrate that moderating adiponectin receptor -1 activity extends lifespan under stress, and directly implicate adiponectin signalling as a coupler between proteostasis and lipid metabolism during ageing.
format	article
author	Emmanouil Kyriakakis Nikolaos Charmpilas Nektarios Tavernarakis
author_facet	Emmanouil Kyriakakis Nikolaos Charmpilas Nektarios Tavernarakis
author_sort	Emmanouil Kyriakakis
title	Differential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegans
title_short	Differential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegans
title_full	Differential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegans
title_fullStr	Differential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegans
title_full_unstemmed	Differential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegans
title_sort	differential adiponectin signalling couples er stress with lipid metabolism to modulate ageing in c. elegans
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/15f33101a3424361ae6e8bfdbd5724b0
work_keys_str_mv	AT emmanouilkyriakakis differentialadiponectinsignallingcoupleserstresswithlipidmetabolismtomodulateageingincelegans AT nikolaoscharmpilas differentialadiponectinsignallingcoupleserstresswithlipidmetabolismtomodulateageingincelegans AT nektariostavernarakis differentialadiponectinsignallingcoupleserstresswithlipidmetabolismtomodulateageingincelegans
_version_	1718389000711962624

Differential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegans

Ejemplares similares