Phage morphology recapitulates phylogeny: the comparative genomics of a new group of myoviruses.

Among dsDNA tailed bacteriophages (Caudovirales), members of the Myoviridae family have the most sophisticated virion design that includes a complex contractile tail structure. The Myoviridae generally have larger genomes than the other phage families. Relatively few "dwarf" myoviruses, th...

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Autores principales:	André M Comeau, Denise Tremblay, Sylvain Moineau, Thomas Rattei, Alla I Kushkina, Fedor I Tovkach, Henry M Krisch, Hans-Wolfgang Ackermann
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15f7f4d73b3f4b1abb121d9f4e8733a0
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spelling	oai:doaj.org-article:15f7f4d73b3f4b1abb121d9f4e8733a02021-11-18T07:13:15ZPhage morphology recapitulates phylogeny: the comparative genomics of a new group of myoviruses.1932-620310.1371/journal.pone.0040102https://doaj.org/article/15f7f4d73b3f4b1abb121d9f4e8733a02012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22792219/?tool=EBIhttps://doaj.org/toc/1932-6203Among dsDNA tailed bacteriophages (Caudovirales), members of the Myoviridae family have the most sophisticated virion design that includes a complex contractile tail structure. The Myoviridae generally have larger genomes than the other phage families. Relatively few "dwarf" myoviruses, those with a genome size of less than 50 kb such as those of the Mu group, have been analyzed in extenso. Here we report on the genome sequencing and morphological characterization of a new group of such phages that infect a diverse range of Proteobacteria, namely Aeromonas salmonicida phage 56, Vibrio cholerae phages 138 and CP-T1, Bdellovibrio phage φ1422, and Pectobacterium carotovorum phage ZF40. This group of dwarf myoviruses shares an identical virion morphology, characterized by usually short contractile tails, and have genome sizes of approximately 45 kb. Although their genome sequences are variable in their lysogeny, replication, and host adaption modules, presumably reflecting differing lifestyles and hosts, their structural and morphogenesis modules have been evolutionarily constrained by their virion morphology. Comparative genomic analysis reveals that these phages, along with related prophage genomes, form a new coherent group within the Myoviridae. The results presented in this communication support the hypothesis that the diversity of phages may be more structured than generally believed and that the innumerable phages in the biosphere all belong to discrete lineages or families.André M ComeauDenise TremblaySylvain MoineauThomas RatteiAlla I KushkinaFedor I TovkachHenry M KrischHans-Wolfgang AckermannPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e40102 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q André M Comeau Denise Tremblay Sylvain Moineau Thomas Rattei Alla I Kushkina Fedor I Tovkach Henry M Krisch Hans-Wolfgang Ackermann Phage morphology recapitulates phylogeny: the comparative genomics of a new group of myoviruses.
description	Among dsDNA tailed bacteriophages (Caudovirales), members of the Myoviridae family have the most sophisticated virion design that includes a complex contractile tail structure. The Myoviridae generally have larger genomes than the other phage families. Relatively few "dwarf" myoviruses, those with a genome size of less than 50 kb such as those of the Mu group, have been analyzed in extenso. Here we report on the genome sequencing and morphological characterization of a new group of such phages that infect a diverse range of Proteobacteria, namely Aeromonas salmonicida phage 56, Vibrio cholerae phages 138 and CP-T1, Bdellovibrio phage φ1422, and Pectobacterium carotovorum phage ZF40. This group of dwarf myoviruses shares an identical virion morphology, characterized by usually short contractile tails, and have genome sizes of approximately 45 kb. Although their genome sequences are variable in their lysogeny, replication, and host adaption modules, presumably reflecting differing lifestyles and hosts, their structural and morphogenesis modules have been evolutionarily constrained by their virion morphology. Comparative genomic analysis reveals that these phages, along with related prophage genomes, form a new coherent group within the Myoviridae. The results presented in this communication support the hypothesis that the diversity of phages may be more structured than generally believed and that the innumerable phages in the biosphere all belong to discrete lineages or families.
format	article
author	André M Comeau Denise Tremblay Sylvain Moineau Thomas Rattei Alla I Kushkina Fedor I Tovkach Henry M Krisch Hans-Wolfgang Ackermann
author_facet	André M Comeau Denise Tremblay Sylvain Moineau Thomas Rattei Alla I Kushkina Fedor I Tovkach Henry M Krisch Hans-Wolfgang Ackermann
author_sort	André M Comeau
title	Phage morphology recapitulates phylogeny: the comparative genomics of a new group of myoviruses.
title_short	Phage morphology recapitulates phylogeny: the comparative genomics of a new group of myoviruses.
title_full	Phage morphology recapitulates phylogeny: the comparative genomics of a new group of myoviruses.
title_fullStr	Phage morphology recapitulates phylogeny: the comparative genomics of a new group of myoviruses.
title_full_unstemmed	Phage morphology recapitulates phylogeny: the comparative genomics of a new group of myoviruses.
title_sort	phage morphology recapitulates phylogeny: the comparative genomics of a new group of myoviruses.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/15f7f4d73b3f4b1abb121d9f4e8733a0
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Phage morphology recapitulates phylogeny: the comparative genomics of a new group of myoviruses.

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