H3.3K27M-induced chromatin changes drive ectopic replication through misregulation of the JNK pathway in C. elegans

Substitution of lysine 27 with methionine in histone H3.3 (H3.3K27M) is a driver mutation of pediatric high-grade gliomas. Here the authors show that H3.3K27M-mediated alterations in H3K27me3 distribution result in ectopic DNA replication and cell cycle progression of germ cells in Caenorhabditis el...

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Autores principales:	Kamila Delaney, Maude Strobino, Joanna M. Wenda, Andrzej Pankowski, Florian A. Steiner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15ff841362f0489ca570360241b3e7f6
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spelling	oai:doaj.org-article:15ff841362f0489ca570360241b3e7f62021-12-02T15:35:02ZH3.3K27M-induced chromatin changes drive ectopic replication through misregulation of the JNK pathway in C. elegans10.1038/s41467-019-10404-92041-1723https://doaj.org/article/15ff841362f0489ca570360241b3e7f62019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10404-9https://doaj.org/toc/2041-1723Substitution of lysine 27 with methionine in histone H3.3 (H3.3K27M) is a driver mutation of pediatric high-grade gliomas. Here the authors show that H3.3K27M-mediated alterations in H3K27me3 distribution result in ectopic DNA replication and cell cycle progression of germ cells in Caenorhabditis elegans, through JNK pathway misregulation.Kamila DelaneyMaude StrobinoJoanna M. WendaAndrzej PankowskiFlorian A. SteinerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kamila Delaney Maude Strobino Joanna M. Wenda Andrzej Pankowski Florian A. Steiner H3.3K27M-induced chromatin changes drive ectopic replication through misregulation of the JNK pathway in C. elegans
description	Substitution of lysine 27 with methionine in histone H3.3 (H3.3K27M) is a driver mutation of pediatric high-grade gliomas. Here the authors show that H3.3K27M-mediated alterations in H3K27me3 distribution result in ectopic DNA replication and cell cycle progression of germ cells in Caenorhabditis elegans, through JNK pathway misregulation.
format	article
author	Kamila Delaney Maude Strobino Joanna M. Wenda Andrzej Pankowski Florian A. Steiner
author_facet	Kamila Delaney Maude Strobino Joanna M. Wenda Andrzej Pankowski Florian A. Steiner
author_sort	Kamila Delaney
title	H3.3K27M-induced chromatin changes drive ectopic replication through misregulation of the JNK pathway in C. elegans
title_short	H3.3K27M-induced chromatin changes drive ectopic replication through misregulation of the JNK pathway in C. elegans
title_full	H3.3K27M-induced chromatin changes drive ectopic replication through misregulation of the JNK pathway in C. elegans
title_fullStr	H3.3K27M-induced chromatin changes drive ectopic replication through misregulation of the JNK pathway in C. elegans
title_full_unstemmed	H3.3K27M-induced chromatin changes drive ectopic replication through misregulation of the JNK pathway in C. elegans
title_sort	h3.3k27m-induced chromatin changes drive ectopic replication through misregulation of the jnk pathway in c. elegans
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/15ff841362f0489ca570360241b3e7f6
work_keys_str_mv	AT kamiladelaney h33k27minducedchromatinchangesdriveectopicreplicationthroughmisregulationofthejnkpathwayincelegans AT maudestrobino h33k27minducedchromatinchangesdriveectopicreplicationthroughmisregulationofthejnkpathwayincelegans AT joannamwenda h33k27minducedchromatinchangesdriveectopicreplicationthroughmisregulationofthejnkpathwayincelegans AT andrzejpankowski h33k27minducedchromatinchangesdriveectopicreplicationthroughmisregulationofthejnkpathwayincelegans AT florianasteiner h33k27minducedchromatinchangesdriveectopicreplicationthroughmisregulationofthejnkpathwayincelegans
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H3.3K27M-induced chromatin changes drive ectopic replication through misregulation of the JNK pathway in C. elegans

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