Integrative modeling of small artery structure and function uncovers critical parameters for diameter regulation.

Organ perfusion is regulated by vasoactivity and structural adaptation of small arteries and arterioles. These resistance vessels are sensitive to pressure, flow and a range of vasoactive stimuli. Several strongly interacting control loops exist. As an example, the myogenic response to a change of p...

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Autores principales:	Ed VanBavel, Bilge Guvenc Tuna
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1603d0528b2b437e8ec23609401b1db1
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spelling	oai:doaj.org-article:1603d0528b2b437e8ec23609401b1db12021-11-18T08:34:39ZIntegrative modeling of small artery structure and function uncovers critical parameters for diameter regulation.1932-620310.1371/journal.pone.0086901https://doaj.org/article/1603d0528b2b437e8ec23609401b1db12014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24497993/?tool=EBIhttps://doaj.org/toc/1932-6203Organ perfusion is regulated by vasoactivity and structural adaptation of small arteries and arterioles. These resistance vessels are sensitive to pressure, flow and a range of vasoactive stimuli. Several strongly interacting control loops exist. As an example, the myogenic response to a change of pressure influences the endothelial shear stress, thereby altering the contribution of shear-dependent dilation to the vascular tone. In addition, acute responses change the stimulus for structural adaptation and vice versa. Such control loops are able to maintain resistance vessels in a functional and stable state, characterized by regulated wall stress, shear stress, matched active and passive biomechanics and presence of vascular reserve. In this modeling study, four adaptation processes are identified that together with biomechanical properties effectuate such integrated regulation: control of tone, smooth muscle cell length adaptation, eutrophic matrix rearrangement and trophic responses. Their combined action maintains arteries in their optimal state, ready to cope with new challenges, allowing continuous long-term vasoregulation. The exclusion of any of these processes results in a poorly regulated state and in some cases instability of vascular structure.Ed VanBavelBilge Guvenc TunaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e86901 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ed VanBavel Bilge Guvenc Tuna Integrative modeling of small artery structure and function uncovers critical parameters for diameter regulation.
description	Organ perfusion is regulated by vasoactivity and structural adaptation of small arteries and arterioles. These resistance vessels are sensitive to pressure, flow and a range of vasoactive stimuli. Several strongly interacting control loops exist. As an example, the myogenic response to a change of pressure influences the endothelial shear stress, thereby altering the contribution of shear-dependent dilation to the vascular tone. In addition, acute responses change the stimulus for structural adaptation and vice versa. Such control loops are able to maintain resistance vessels in a functional and stable state, characterized by regulated wall stress, shear stress, matched active and passive biomechanics and presence of vascular reserve. In this modeling study, four adaptation processes are identified that together with biomechanical properties effectuate such integrated regulation: control of tone, smooth muscle cell length adaptation, eutrophic matrix rearrangement and trophic responses. Their combined action maintains arteries in their optimal state, ready to cope with new challenges, allowing continuous long-term vasoregulation. The exclusion of any of these processes results in a poorly regulated state and in some cases instability of vascular structure.
format	article
author	Ed VanBavel Bilge Guvenc Tuna
author_facet	Ed VanBavel Bilge Guvenc Tuna
author_sort	Ed VanBavel
title	Integrative modeling of small artery structure and function uncovers critical parameters for diameter regulation.
title_short	Integrative modeling of small artery structure and function uncovers critical parameters for diameter regulation.
title_full	Integrative modeling of small artery structure and function uncovers critical parameters for diameter regulation.
title_fullStr	Integrative modeling of small artery structure and function uncovers critical parameters for diameter regulation.
title_full_unstemmed	Integrative modeling of small artery structure and function uncovers critical parameters for diameter regulation.
title_sort	integrative modeling of small artery structure and function uncovers critical parameters for diameter regulation.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/1603d0528b2b437e8ec23609401b1db1
work_keys_str_mv	AT edvanbavel integrativemodelingofsmallarterystructureandfunctionuncoverscriticalparametersfordiameterregulation AT bilgeguvenctuna integrativemodelingofsmallarterystructureandfunctionuncoverscriticalparametersfordiameterregulation
_version_	1718421605450776576

Integrative modeling of small artery structure and function uncovers critical parameters for diameter regulation.

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