Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis

RNA m6A demethylase FTO has oncogenic roles in cancers. Here the authors show that chronic low-level exposure of arsenic inhibits autophagic degradation of FTO, leading to FTO stabilisation and reduced m6A RNA methylation in keratinocytes and its subsequent malignant transformation.

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Autores principales:	Yan-Hong Cui, Seungwon Yang, Jiangbo Wei, Christopher R. Shea, Wen Zhong, Fang Wang, Palak Shah, Muhammad G. Kibriya, Xiaolong Cui, Habibul Ahsan, Chuan He, Yu-Ying He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/160d09c1cbca43a7a7924d3f18fd2280
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spelling	oai:doaj.org-article:160d09c1cbca43a7a7924d3f18fd22802021-12-02T18:02:55ZAutophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis10.1038/s41467-021-22469-62041-1723https://doaj.org/article/160d09c1cbca43a7a7924d3f18fd22802021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22469-6https://doaj.org/toc/2041-1723RNA m6A demethylase FTO has oncogenic roles in cancers. Here the authors show that chronic low-level exposure of arsenic inhibits autophagic degradation of FTO, leading to FTO stabilisation and reduced m6A RNA methylation in keratinocytes and its subsequent malignant transformation.Yan-Hong CuiSeungwon YangJiangbo WeiChristopher R. SheaWen ZhongFang WangPalak ShahMuhammad G. KibriyaXiaolong CuiHabibul AhsanChuan HeYu-Ying HeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yan-Hong Cui Seungwon Yang Jiangbo Wei Christopher R. Shea Wen Zhong Fang Wang Palak Shah Muhammad G. Kibriya Xiaolong Cui Habibul Ahsan Chuan He Yu-Ying He Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis
description	RNA m6A demethylase FTO has oncogenic roles in cancers. Here the authors show that chronic low-level exposure of arsenic inhibits autophagic degradation of FTO, leading to FTO stabilisation and reduced m6A RNA methylation in keratinocytes and its subsequent malignant transformation.
format	article
author	Yan-Hong Cui Seungwon Yang Jiangbo Wei Christopher R. Shea Wen Zhong Fang Wang Palak Shah Muhammad G. Kibriya Xiaolong Cui Habibul Ahsan Chuan He Yu-Ying He
author_facet	Yan-Hong Cui Seungwon Yang Jiangbo Wei Christopher R. Shea Wen Zhong Fang Wang Palak Shah Muhammad G. Kibriya Xiaolong Cui Habibul Ahsan Chuan He Yu-Ying He
author_sort	Yan-Hong Cui
title	Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis
title_short	Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis
title_full	Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis
title_fullStr	Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis
title_full_unstemmed	Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis
title_sort	autophagy of the m6a mrna demethylase fto is impaired by low-level arsenic exposure to promote tumorigenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/160d09c1cbca43a7a7924d3f18fd2280
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Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis

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