Multiplex suppression of four quadruplet codons via tRNA directed evolution

Genetic code expansion strategies are limited to specific codons that can be reassigned to new amino acids. Here the authors show that quadruplet-decoding tRNAs (qtRNAs) can be rapidly discovered and evolved to decode new quadruplet codons, enabling four independent decoding events in a single prote...

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Autores principales: Erika A. DeBenedictis, Gavriela D. Carver, Christina Z. Chung, Dieter Söll, Ahmed H. Badran
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/160d7d8ec84743218f1d2a710d9af0a0
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