Multiplex suppression of four quadruplet codons via tRNA directed evolution

Genetic code expansion strategies are limited to specific codons that can be reassigned to new amino acids. Here the authors show that quadruplet-decoding tRNAs (qtRNAs) can be rapidly discovered and evolved to decode new quadruplet codons, enabling four independent decoding events in a single prote...

Full description

Saved in:
Bibliographic Details
Main Authors: Erika A. DeBenedictis, Gavriela D. Carver, Christina Z. Chung, Dieter Söll, Ahmed H. Badran
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Q
Online Access:https://doaj.org/article/160d7d8ec84743218f1d2a710d9af0a0
Tags: Add Tag
No Tags, Be the first to tag this record!