Born to survive: how cancer cells resist CAR T cell therapy

Abstract Although chimeric antigen receptor T cells demonstrated remarkable efficacy in patients with chemo-resistant hematologic malignancies, a significant portion still resist or relapse. This immune evasion may be due to CAR T cells dysfunction, a hostile tumor microenvironment, or resistant can...

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Autores principales: Jean Lemoine, Marco Ruella, Roch Houot
Formato: article
Lenguaje:EN
Publicado: BMC 2021
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Acceso en línea:https://doaj.org/article/160e195e48c640ac9e65ed6f10b77e15
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