Ceramides bind VDAC2 to trigger mitochondrial apoptosis

Ceramides are lipids that act directly on mitochondria to trigger apoptosis, but the underlying mechanism remains largely unclear. Here authors use a photoactivatable ceramide probe combined with a computation approach and functional studies to identify the voltage-dependent anion channel VDAC2 as a...

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Autores principales:	Shashank Dadsena, Svenja Bockelmann, John G. M. Mina, Dina G. Hassan, Sergei Korneev, Guilherme Razzera, Helene Jahn, Patrick Niekamp, Dagmar Müller, Markus Schneider, Fikadu G. Tafesse, Siewert J. Marrink, Manuel N. Melo, Joost C. M. Holthuis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/161032635f8246f6afb463a1fd58d74b
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spelling	oai:doaj.org-article:161032635f8246f6afb463a1fd58d74b2021-12-02T14:38:58ZCeramides bind VDAC2 to trigger mitochondrial apoptosis10.1038/s41467-019-09654-42041-1723https://doaj.org/article/161032635f8246f6afb463a1fd58d74b2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09654-4https://doaj.org/toc/2041-1723Ceramides are lipids that act directly on mitochondria to trigger apoptosis, but the underlying mechanism remains largely unclear. Here authors use a photoactivatable ceramide probe combined with a computation approach and functional studies to identify the voltage-dependent anion channel VDAC2 as a direct effector of ceramide-mediated cell death.Shashank DadsenaSvenja BockelmannJohn G. M. MinaDina G. HassanSergei KorneevGuilherme RazzeraHelene JahnPatrick NiekampDagmar MüllerMarkus SchneiderFikadu G. TafesseSiewert J. MarrinkManuel N. MeloJoost C. M. HolthuisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shashank Dadsena Svenja Bockelmann John G. M. Mina Dina G. Hassan Sergei Korneev Guilherme Razzera Helene Jahn Patrick Niekamp Dagmar Müller Markus Schneider Fikadu G. Tafesse Siewert J. Marrink Manuel N. Melo Joost C. M. Holthuis Ceramides bind VDAC2 to trigger mitochondrial apoptosis
description	Ceramides are lipids that act directly on mitochondria to trigger apoptosis, but the underlying mechanism remains largely unclear. Here authors use a photoactivatable ceramide probe combined with a computation approach and functional studies to identify the voltage-dependent anion channel VDAC2 as a direct effector of ceramide-mediated cell death.
format	article
author	Shashank Dadsena Svenja Bockelmann John G. M. Mina Dina G. Hassan Sergei Korneev Guilherme Razzera Helene Jahn Patrick Niekamp Dagmar Müller Markus Schneider Fikadu G. Tafesse Siewert J. Marrink Manuel N. Melo Joost C. M. Holthuis
author_facet	Shashank Dadsena Svenja Bockelmann John G. M. Mina Dina G. Hassan Sergei Korneev Guilherme Razzera Helene Jahn Patrick Niekamp Dagmar Müller Markus Schneider Fikadu G. Tafesse Siewert J. Marrink Manuel N. Melo Joost C. M. Holthuis
author_sort	Shashank Dadsena
title	Ceramides bind VDAC2 to trigger mitochondrial apoptosis
title_short	Ceramides bind VDAC2 to trigger mitochondrial apoptosis
title_full	Ceramides bind VDAC2 to trigger mitochondrial apoptosis
title_fullStr	Ceramides bind VDAC2 to trigger mitochondrial apoptosis
title_full_unstemmed	Ceramides bind VDAC2 to trigger mitochondrial apoptosis
title_sort	ceramides bind vdac2 to trigger mitochondrial apoptosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/161032635f8246f6afb463a1fd58d74b
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Ceramides bind VDAC2 to trigger mitochondrial apoptosis

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