Effects of somatic treatments on suicidal ideation and completed suicides

Abstract Objective This work was undertaken to define and characterize the role of currently available somatic treatments in psychiatry in either increasing or reducing the risk for suicide. Methods Members of the Suicide Prevention Task Group of the National Network of Depression Centers performed...

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Autores principales:	Elise M Hawkins, William Coryell, Stephen Leung, Sagar V. Parikh, Cody Weston, Paul Nestadt, John I. Nurnberger Jr., Adam Kaplin, Anupama Kumar, Ali A. Farooqui, Rif S. El‐Mallakh, For the National Network of Depression Centers Suicide Prevention Task Group
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	antidepressants clozapine esketamine ketamine lithium protective Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/1612277ac905451991171224d8ae7ee4
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spelling	oai:doaj.org-article:1612277ac905451991171224d8ae7ee42021-11-25T06:06:36ZEffects of somatic treatments on suicidal ideation and completed suicides2162-327910.1002/brb3.2381https://doaj.org/article/1612277ac905451991171224d8ae7ee42021-11-01T00:00:00Zhttps://doi.org/10.1002/brb3.2381https://doaj.org/toc/2162-3279Abstract Objective This work was undertaken to define and characterize the role of currently available somatic treatments in psychiatry in either increasing or reducing the risk for suicide. Methods Members of the Suicide Prevention Task Group of the National Network of Depression Centers performed a literature review of somatic treatments known to increase or reduce the risk for suicide. The reviews ventured to include all relevant information about the risk for both suicide ideation and completed suicides. Results Lithium and clozapine are the only two somatic treatments that have high‐quality data documenting their antisuicide effects in mood disorders and schizophrenia, respectively. Lithium discontinuation is also associated with increased suicide risk. Ketamine and esketamine may have a small, but immediate, antisuicide effect. Despite the recent Food and Drug Administration approval of esketamine use in depressed suicidal patients, the small disproportional overrepresentation of suicide in subjects who had received esketamine versus placebo (3 vs. 0 among > 3500 subjects) requires ongoing evaluation. The purported antisuicide effect of electroconvulsive therapy is based on low‐quality data. The effect of antidepressants is not at all clear. There appears to be direct evidence for antidepressants increasing suicidal ideation and the risk for suicide over the short‐term in young people, but indirect (low quality) evidence that antidepressants reduce suicide risk over the long term. Conclusions Clinicians have an expanding pharmacopeia to address suicide potential in their patients. Some of the agents with documented antisuicide effects may also increase suicidality under specific circumstances.Elise M HawkinsWilliam CoryellStephen LeungSagar V. ParikhCody WestonPaul NestadtJohn I. Nurnberger Jr.Adam KaplinAnupama KumarAli A. FarooquiRif S. El‐MallakhFor the National Network of Depression Centers Suicide Prevention Task GroupWileyarticleantidepressantsclozapineesketamineketaminelithiumprotectiveNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain and Behavior, Vol 11, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antidepressants clozapine esketamine ketamine lithium protective Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	antidepressants clozapine esketamine ketamine lithium protective Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Elise M Hawkins William Coryell Stephen Leung Sagar V. Parikh Cody Weston Paul Nestadt John I. Nurnberger Jr. Adam Kaplin Anupama Kumar Ali A. Farooqui Rif S. El‐Mallakh For the National Network of Depression Centers Suicide Prevention Task Group Effects of somatic treatments on suicidal ideation and completed suicides
description	Abstract Objective This work was undertaken to define and characterize the role of currently available somatic treatments in psychiatry in either increasing or reducing the risk for suicide. Methods Members of the Suicide Prevention Task Group of the National Network of Depression Centers performed a literature review of somatic treatments known to increase or reduce the risk for suicide. The reviews ventured to include all relevant information about the risk for both suicide ideation and completed suicides. Results Lithium and clozapine are the only two somatic treatments that have high‐quality data documenting their antisuicide effects in mood disorders and schizophrenia, respectively. Lithium discontinuation is also associated with increased suicide risk. Ketamine and esketamine may have a small, but immediate, antisuicide effect. Despite the recent Food and Drug Administration approval of esketamine use in depressed suicidal patients, the small disproportional overrepresentation of suicide in subjects who had received esketamine versus placebo (3 vs. 0 among > 3500 subjects) requires ongoing evaluation. The purported antisuicide effect of electroconvulsive therapy is based on low‐quality data. The effect of antidepressants is not at all clear. There appears to be direct evidence for antidepressants increasing suicidal ideation and the risk for suicide over the short‐term in young people, but indirect (low quality) evidence that antidepressants reduce suicide risk over the long term. Conclusions Clinicians have an expanding pharmacopeia to address suicide potential in their patients. Some of the agents with documented antisuicide effects may also increase suicidality under specific circumstances.
format	article
author	Elise M Hawkins William Coryell Stephen Leung Sagar V. Parikh Cody Weston Paul Nestadt John I. Nurnberger Jr. Adam Kaplin Anupama Kumar Ali A. Farooqui Rif S. El‐Mallakh For the National Network of Depression Centers Suicide Prevention Task Group
author_facet	Elise M Hawkins William Coryell Stephen Leung Sagar V. Parikh Cody Weston Paul Nestadt John I. Nurnberger Jr. Adam Kaplin Anupama Kumar Ali A. Farooqui Rif S. El‐Mallakh For the National Network of Depression Centers Suicide Prevention Task Group
author_sort	Elise M Hawkins
title	Effects of somatic treatments on suicidal ideation and completed suicides
title_short	Effects of somatic treatments on suicidal ideation and completed suicides
title_full	Effects of somatic treatments on suicidal ideation and completed suicides
title_fullStr	Effects of somatic treatments on suicidal ideation and completed suicides
title_full_unstemmed	Effects of somatic treatments on suicidal ideation and completed suicides
title_sort	effects of somatic treatments on suicidal ideation and completed suicides
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/1612277ac905451991171224d8ae7ee4
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Effects of somatic treatments on suicidal ideation and completed suicides

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