Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis

Triple-negative breast cancers (TNBC), as a group of tumours, have a worse prognosis than stage-matched non-TNBC and lack the benefits of routinely available targeted therapy. However, TNBC is a heterogeneous group of neoplasms, which includes some special type carcinomas with a relatively indolent...

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Autores principales:	Gábor Cserni, Cecily M. Quinn, Maria Pia Foschini, Simonetta Bianchi, Grace Callagy, Ewa Chmielik, Thomas Decker, Falko Fend, Anikó Kovács, Paul J. van Diest, Ian O. Ellis, Emad Rakha, Tibor Tot, European Working Group for Breast Screening Pathology
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	acinic cell carcinoma adenoid cystic carcinoma fibromatosis like metaplastic carcinoma low-grade adenosquamous carcinoma mucoepidermoid carcinoma secretory carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/16138480a83a426f85f5aec622bb0733
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spelling	oai:doaj.org-article:16138480a83a426f85f5aec622bb07332021-11-25T17:02:44ZTriple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis10.3390/cancers132256942072-6694https://doaj.org/article/16138480a83a426f85f5aec622bb07332021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5694https://doaj.org/toc/2072-6694Triple-negative breast cancers (TNBC), as a group of tumours, have a worse prognosis than stage-matched non-TNBC and lack the benefits of routinely available targeted therapy. However, TNBC is a heterogeneous group of neoplasms, which includes some special type carcinomas with a relatively indolent course. This review on behalf of the European Working Group for Breast Screening Pathology reviews the literature on the special histological types of BC that are reported to have a triple negative phenotype and indolent behaviour. These include adenoid cystic carcinoma of classical type, low-grade adenosquamous carcinoma, fibromatosis-like metaplastic carcinoma, low-grade mucoepidermoid carcinoma, secretory carcinoma, acinic cell carcinoma, and tall cell carcinoma with reversed polarity. The pathological and known molecular features as well as clinical data including treatment and prognosis of these special TNBC subtypes are summarised and it is concluded that many patients with these rare TNBC pure subtypes are unlikely to benefit from systemic chemotherapy. A consensus statement of the working group relating to the multidisciplinary approach and treatment of these rare tumour types concludes the review.Gábor CserniCecily M. QuinnMaria Pia FoschiniSimonetta BianchiGrace CallagyEwa ChmielikThomas DeckerFalko FendAnikó KovácsPaul J. van DiestIan O. EllisEmad RakhaTibor TotEuropean Working Group for Breast Screening PathologyMDPI AGarticleacinic cell carcinomaadenoid cystic carcinomafibromatosis like metaplastic carcinomalow-grade adenosquamous carcinomamucoepidermoid carcinomasecretory carcinomaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5694, p 5694 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acinic cell carcinoma adenoid cystic carcinoma fibromatosis like metaplastic carcinoma low-grade adenosquamous carcinoma mucoepidermoid carcinoma secretory carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	acinic cell carcinoma adenoid cystic carcinoma fibromatosis like metaplastic carcinoma low-grade adenosquamous carcinoma mucoepidermoid carcinoma secretory carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Gábor Cserni Cecily M. Quinn Maria Pia Foschini Simonetta Bianchi Grace Callagy Ewa Chmielik Thomas Decker Falko Fend Anikó Kovács Paul J. van Diest Ian O. Ellis Emad Rakha Tibor Tot European Working Group for Breast Screening Pathology Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis
description	Triple-negative breast cancers (TNBC), as a group of tumours, have a worse prognosis than stage-matched non-TNBC and lack the benefits of routinely available targeted therapy. However, TNBC is a heterogeneous group of neoplasms, which includes some special type carcinomas with a relatively indolent course. This review on behalf of the European Working Group for Breast Screening Pathology reviews the literature on the special histological types of BC that are reported to have a triple negative phenotype and indolent behaviour. These include adenoid cystic carcinoma of classical type, low-grade adenosquamous carcinoma, fibromatosis-like metaplastic carcinoma, low-grade mucoepidermoid carcinoma, secretory carcinoma, acinic cell carcinoma, and tall cell carcinoma with reversed polarity. The pathological and known molecular features as well as clinical data including treatment and prognosis of these special TNBC subtypes are summarised and it is concluded that many patients with these rare TNBC pure subtypes are unlikely to benefit from systemic chemotherapy. A consensus statement of the working group relating to the multidisciplinary approach and treatment of these rare tumour types concludes the review.
format	article
author	Gábor Cserni Cecily M. Quinn Maria Pia Foschini Simonetta Bianchi Grace Callagy Ewa Chmielik Thomas Decker Falko Fend Anikó Kovács Paul J. van Diest Ian O. Ellis Emad Rakha Tibor Tot European Working Group for Breast Screening Pathology
author_facet	Gábor Cserni Cecily M. Quinn Maria Pia Foschini Simonetta Bianchi Grace Callagy Ewa Chmielik Thomas Decker Falko Fend Anikó Kovács Paul J. van Diest Ian O. Ellis Emad Rakha Tibor Tot European Working Group for Breast Screening Pathology
author_sort	Gábor Cserni
title	Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis
title_short	Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis
title_full	Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis
title_fullStr	Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis
title_full_unstemmed	Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis
title_sort	triple-negative breast cancer histological subtypes with a favourable prognosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/16138480a83a426f85f5aec622bb0733
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Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis

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