A role for central nervous growth hormone-releasing hormone signaling in the consolidation of declarative memories.

Contributions of somatotropic hormonal activity to memory functions in humans, which are suggested by clinical observations, have not been systematically examined. With previous experiments precluding a direct effect of systemic growth hormone (GH) on acute memory formation, we assessed the role of...

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Autores principales:	Manfred Hallschmid, Ines Wilhelm, Christian Michel, Boris Perras, Jan Born
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1613cf4adbcb43ada2902f4c6103a47e
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spelling	oai:doaj.org-article:1613cf4adbcb43ada2902f4c6103a47e2021-11-18T06:48:30ZA role for central nervous growth hormone-releasing hormone signaling in the consolidation of declarative memories.1932-620310.1371/journal.pone.0023435https://doaj.org/article/1613cf4adbcb43ada2902f4c6103a47e2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21850272/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Contributions of somatotropic hormonal activity to memory functions in humans, which are suggested by clinical observations, have not been systematically examined. With previous experiments precluding a direct effect of systemic growth hormone (GH) on acute memory formation, we assessed the role of central nervous somatotropic signaling in declarative memory consolidation. We examined the effect of intranasally administered growth hormone releasing-hormone (GHRH; 600 µg) that has direct access to the brain and suppresses endogenous GHRH via an ultra-short negative feedback loop. Twelve healthy young men learned word-pair associates at 2030 h and were administered GHRH and placebo, respectively, at 2100 h. Retrieval was tested after 11 hours of wakefulness. Compared to placebo, intranasal GHRH blunted GH release within 3 hours after substance administration and reduced the number of correctly recalled word-pairs by ∼12% (both P<0.05). The impairment of declarative memory consolidation was directly correlated to diminished GH concentrations (P<0.05). Procedural memory consolidation as examined by the parallel assessment of finger sequence tapping performance was not affected by GHRH administration. Our findings indicate that intranasal GHRH, by counteracting endogenous GHRH release, impairs hippocampal memory processing. They provide first evidence for a critical contribution of central nervous somatotropic activity to hippocampus-dependent memory consolidation.Manfred HallschmidInes WilhelmChristian MichelBoris PerrasJan BornPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e23435 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manfred Hallschmid Ines Wilhelm Christian Michel Boris Perras Jan Born A role for central nervous growth hormone-releasing hormone signaling in the consolidation of declarative memories.
description	Contributions of somatotropic hormonal activity to memory functions in humans, which are suggested by clinical observations, have not been systematically examined. With previous experiments precluding a direct effect of systemic growth hormone (GH) on acute memory formation, we assessed the role of central nervous somatotropic signaling in declarative memory consolidation. We examined the effect of intranasally administered growth hormone releasing-hormone (GHRH; 600 µg) that has direct access to the brain and suppresses endogenous GHRH via an ultra-short negative feedback loop. Twelve healthy young men learned word-pair associates at 2030 h and were administered GHRH and placebo, respectively, at 2100 h. Retrieval was tested after 11 hours of wakefulness. Compared to placebo, intranasal GHRH blunted GH release within 3 hours after substance administration and reduced the number of correctly recalled word-pairs by ∼12% (both P<0.05). The impairment of declarative memory consolidation was directly correlated to diminished GH concentrations (P<0.05). Procedural memory consolidation as examined by the parallel assessment of finger sequence tapping performance was not affected by GHRH administration. Our findings indicate that intranasal GHRH, by counteracting endogenous GHRH release, impairs hippocampal memory processing. They provide first evidence for a critical contribution of central nervous somatotropic activity to hippocampus-dependent memory consolidation.
format	article
author	Manfred Hallschmid Ines Wilhelm Christian Michel Boris Perras Jan Born
author_facet	Manfred Hallschmid Ines Wilhelm Christian Michel Boris Perras Jan Born
author_sort	Manfred Hallschmid
title	A role for central nervous growth hormone-releasing hormone signaling in the consolidation of declarative memories.
title_short	A role for central nervous growth hormone-releasing hormone signaling in the consolidation of declarative memories.
title_full	A role for central nervous growth hormone-releasing hormone signaling in the consolidation of declarative memories.
title_fullStr	A role for central nervous growth hormone-releasing hormone signaling in the consolidation of declarative memories.
title_full_unstemmed	A role for central nervous growth hormone-releasing hormone signaling in the consolidation of declarative memories.
title_sort	role for central nervous growth hormone-releasing hormone signaling in the consolidation of declarative memories.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/1613cf4adbcb43ada2902f4c6103a47e
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A role for central nervous growth hormone-releasing hormone signaling in the consolidation of declarative memories.

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