MicroRNAs as B-cell lymphoma biomarkers

Lorea Manterola,1 Marta Fernandez-Mercado,1 Erika Larrea,1 Ibai Goicoechea,1 María Arestin,1 María Armesto,1 Luiza Hernandez,1 Charles H Lawrie1,2,3 1Oncology Area, Biodonostia Research Institute, San Sebastián, Spain; 2Nuffield Department of Clinical Laboratory Sci...

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Autores principales:	Manterola L, Fernandez-Mercado M, Larrea E, Goicoechea I, Arestin M, Armesto M, Hernandez L, Lawrie CH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/16162ae744164af9afa9f88937cee74f
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spelling	oai:doaj.org-article:16162ae744164af9afa9f88937cee74f2021-12-02T03:23:49ZMicroRNAs as B-cell lymphoma biomarkers1179-9889https://doaj.org/article/16162ae744164af9afa9f88937cee74f2015-02-01T00:00:00Zhttp://www.dovepress.com/micrornas-as-b-cell-lymphoma-biomarkers-peer-reviewed-article-BLCTThttps://doaj.org/toc/1179-9889 Lorea Manterola,1 Marta Fernandez-Mercado,1 Erika Larrea,1 Ibai Goicoechea,1 María Arestin,1 María Armesto,1 Luiza Hernandez,1 Charles H Lawrie1,2,3 1Oncology Area, Biodonostia Research Institute, San Sebastián, Spain; 2Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK; 3Ikerbasque, Basque Foundation for Science, Bilbao, Spain Abstract: B-cell lymphomas represent a group of more than 35 recognized mature B-cell neoplasms differentiated largely on the basis of immunohistochemical staining patterns that are often challenging to accurately diagnose. Despite having been only formally recognized just over 10 years ago, microRNAs (miRNAs) have become one of the trendiest topics in biology. Dysregulation of miRNAs is a ubiquitous feature of cancer in general, including B-cell lymphomas. Many of the miRNAs aberrantly expressed in B-cell lymphomas also play a crucial regulatory role in normal hematopoietic function. MiRNAs show great potential as novel biomarkers of cancer, as they can differentiate cancers according to diagnosis and developmental stage, even discriminating between cancers that are poorly separated histologically. Furthermore, they can be robustly measured from routinely prepared formalin-fixed paraffin-embedded biopsy material and biological fluids such as blood. Here, we consider the identity, function, and biomarker potential of miRNAs in B-cell lymphomas and, most importantly, the hurdles that remain to be overcome if they are really to become part of future clinical practice. Keywords: microRNA, lymphoma, biomarker, B-cell Manterola LFernandez-Mercado MLarrea EGoicoechea IArestin MArmesto MHernandez LLawrie CHDove Medical PressarticleDiseases of the blood and blood-forming organsRC633-647.5ENBlood and Lymphatic Cancer: Targets and Therapy, Vol 2015, Iss default, Pp 25-34 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Manterola L Fernandez-Mercado M Larrea E Goicoechea I Arestin M Armesto M Hernandez L Lawrie CH MicroRNAs as B-cell lymphoma biomarkers
description	Lorea Manterola,1 Marta Fernandez-Mercado,1 Erika Larrea,1 Ibai Goicoechea,1 María Arestin,1 María Armesto,1 Luiza Hernandez,1 Charles H Lawrie1,2,3 1Oncology Area, Biodonostia Research Institute, San Sebastián, Spain; 2Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK; 3Ikerbasque, Basque Foundation for Science, Bilbao, Spain Abstract: B-cell lymphomas represent a group of more than 35 recognized mature B-cell neoplasms differentiated largely on the basis of immunohistochemical staining patterns that are often challenging to accurately diagnose. Despite having been only formally recognized just over 10 years ago, microRNAs (miRNAs) have become one of the trendiest topics in biology. Dysregulation of miRNAs is a ubiquitous feature of cancer in general, including B-cell lymphomas. Many of the miRNAs aberrantly expressed in B-cell lymphomas also play a crucial regulatory role in normal hematopoietic function. MiRNAs show great potential as novel biomarkers of cancer, as they can differentiate cancers according to diagnosis and developmental stage, even discriminating between cancers that are poorly separated histologically. Furthermore, they can be robustly measured from routinely prepared formalin-fixed paraffin-embedded biopsy material and biological fluids such as blood. Here, we consider the identity, function, and biomarker potential of miRNAs in B-cell lymphomas and, most importantly, the hurdles that remain to be overcome if they are really to become part of future clinical practice. Keywords: microRNA, lymphoma, biomarker, B-cell
format	article
author	Manterola L Fernandez-Mercado M Larrea E Goicoechea I Arestin M Armesto M Hernandez L Lawrie CH
author_facet	Manterola L Fernandez-Mercado M Larrea E Goicoechea I Arestin M Armesto M Hernandez L Lawrie CH
author_sort	Manterola L
title	MicroRNAs as B-cell lymphoma biomarkers
title_short	MicroRNAs as B-cell lymphoma biomarkers
title_full	MicroRNAs as B-cell lymphoma biomarkers
title_fullStr	MicroRNAs as B-cell lymphoma biomarkers
title_full_unstemmed	MicroRNAs as B-cell lymphoma biomarkers
title_sort	micrornas as b-cell lymphoma biomarkers
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/16162ae744164af9afa9f88937cee74f
work_keys_str_mv	AT manterolal micrornasasbcelllymphomabiomarkers AT fernandezmercadom micrornasasbcelllymphomabiomarkers AT larreae micrornasasbcelllymphomabiomarkers AT goicoecheai micrornasasbcelllymphomabiomarkers AT arestinm micrornasasbcelllymphomabiomarkers AT armestom micrornasasbcelllymphomabiomarkers AT hernandezl micrornasasbcelllymphomabiomarkers AT lawriech micrornasasbcelllymphomabiomarkers
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MicroRNAs as B-cell lymphoma biomarkers

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