The role of serum apelin in retinopathy of prematurity

Yasser F Ali,1 Salah El-Morshedy,1 Abdulbasit Abdulhalim Imam,2 Nasser Ismai A Abdelrahman,1 Riad M Elsayed,3 Usama M Alkholy,1 Nermin Abdalmonem,1 Mohammed M Shehab1 1Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, 2Department of Pediatrics, Al-Azhar Faculty of...

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Autores principales:	Ali YF, El-Morshedy S, Imam AA, Abdelrahman NIA, Elsayed RM, Alkholy UM, Abdalmonem N, Shehab MM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Retinopathy of prematurity preterm infants serum Apelin Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1616bd7d80844cdc969c5823212a8644
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spelling	oai:doaj.org-article:1616bd7d80844cdc969c5823212a86442021-12-02T04:40:20ZThe role of serum apelin in retinopathy of prematurity1177-5483https://doaj.org/article/1616bd7d80844cdc969c5823212a86442017-02-01T00:00:00Zhttps://www.dovepress.com/the-role-of-serum-apelin-in-retinopathy-of-prematurity-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Yasser F Ali,1 Salah El-Morshedy,1 Abdulbasit Abdulhalim Imam,2 Nasser Ismai A Abdelrahman,1 Riad M Elsayed,3 Usama M Alkholy,1 Nermin Abdalmonem,1 Mohammed M Shehab1 1Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, 2Department of Pediatrics, Al-Azhar Faculty of Medicine-Girls, Cairo, 3Pediatric Neurology Unit, Pediatric Department, Mansoura University, Mansoura, Egypt Objective: To evaluate the role of serum apelin as a diagnostic tool in retinopathy of prematurity (ROP) disease.Patients and methods: Thirty-eight preterm infants (60% male) with gestational age ranging from 30 to 36 weeks admitted to the neonatal intensive care unit, KJO Hospital, Saudi Arabia with proven diagnosis of ROP were included in the study. In addition, 27 preterm infants without ROP served as controls. All newborn infants in the study were subjected to adequate history taking, full clinical examination, and fundus examination by indirect ophthalmoscope (at 4–6 weeks) as well as determination of serum apelin at birth and at 4–6 weeks of age.Results: The study revealed that oxygen therapy longer than 7 days’ duration, cesarean section (as a mode of delivery), sepsis, mechanical ventilation, blood transfusion, premature rupture of membranes, pneumothorax, perinatal asphyxia, cardiac problems, and neonatal jaundice were considered as risk factors related to development of ROP. Serum apelin levels were significantly lower in patients than controls (P<0.001) at time of diagnosis of the disease (4–6 weeks) while no significant differences were observed in levels at birth.Conclusion: Serum apelin was found to be of significant diagnostic value in the occurrence of ROP. Keywords: retinopathy of prematurity, preterm infants, serum apelinAli YFEl-Morshedy SImam AAAbdelrahman NIAElsayed RMAlkholy UMAbdalmonem NShehab MMDove Medical PressarticleRetinopathy of prematuritypreterm infantsserum ApelinOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 387-392 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Retinopathy of prematurity preterm infants serum Apelin Ophthalmology RE1-994
spellingShingle	Retinopathy of prematurity preterm infants serum Apelin Ophthalmology RE1-994 Ali YF El-Morshedy S Imam AA Abdelrahman NIA Elsayed RM Alkholy UM Abdalmonem N Shehab MM The role of serum apelin in retinopathy of prematurity
description	Yasser F Ali,1 Salah El-Morshedy,1 Abdulbasit Abdulhalim Imam,2 Nasser Ismai A Abdelrahman,1 Riad M Elsayed,3 Usama M Alkholy,1 Nermin Abdalmonem,1 Mohammed M Shehab1 1Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, 2Department of Pediatrics, Al-Azhar Faculty of Medicine-Girls, Cairo, 3Pediatric Neurology Unit, Pediatric Department, Mansoura University, Mansoura, Egypt Objective: To evaluate the role of serum apelin as a diagnostic tool in retinopathy of prematurity (ROP) disease.Patients and methods: Thirty-eight preterm infants (60% male) with gestational age ranging from 30 to 36 weeks admitted to the neonatal intensive care unit, KJO Hospital, Saudi Arabia with proven diagnosis of ROP were included in the study. In addition, 27 preterm infants without ROP served as controls. All newborn infants in the study were subjected to adequate history taking, full clinical examination, and fundus examination by indirect ophthalmoscope (at 4–6 weeks) as well as determination of serum apelin at birth and at 4–6 weeks of age.Results: The study revealed that oxygen therapy longer than 7 days’ duration, cesarean section (as a mode of delivery), sepsis, mechanical ventilation, blood transfusion, premature rupture of membranes, pneumothorax, perinatal asphyxia, cardiac problems, and neonatal jaundice were considered as risk factors related to development of ROP. Serum apelin levels were significantly lower in patients than controls (P<0.001) at time of diagnosis of the disease (4–6 weeks) while no significant differences were observed in levels at birth.Conclusion: Serum apelin was found to be of significant diagnostic value in the occurrence of ROP. Keywords: retinopathy of prematurity, preterm infants, serum apelin
format	article
author	Ali YF El-Morshedy S Imam AA Abdelrahman NIA Elsayed RM Alkholy UM Abdalmonem N Shehab MM
author_facet	Ali YF El-Morshedy S Imam AA Abdelrahman NIA Elsayed RM Alkholy UM Abdalmonem N Shehab MM
author_sort	Ali YF
title	The role of serum apelin in retinopathy of prematurity
title_short	The role of serum apelin in retinopathy of prematurity
title_full	The role of serum apelin in retinopathy of prematurity
title_fullStr	The role of serum apelin in retinopathy of prematurity
title_full_unstemmed	The role of serum apelin in retinopathy of prematurity
title_sort	role of serum apelin in retinopathy of prematurity
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/1616bd7d80844cdc969c5823212a8644
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The role of serum apelin in retinopathy of prematurity

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