Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy

The mechanism of PARP1-dependent poly-ADP-ribosylation in response to DNA damage is still under debate. Here, the authors use ATR-FTIR spectroscopy to provide time-resolved insights into the molecular details of this process under near physiological conditions.

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Autores principales:	Annika Krüger, Alexander Bürkle, Karin Hauser, Aswin Mangerich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1616d84778de4c2386df75ff6b8c0ab3
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spelling	oai:doaj.org-article:1616d84778de4c2386df75ff6b8c0ab32021-12-02T17:31:24ZReal-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy10.1038/s41467-020-15858-w2041-1723https://doaj.org/article/1616d84778de4c2386df75ff6b8c0ab32020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15858-whttps://doaj.org/toc/2041-1723The mechanism of PARP1-dependent poly-ADP-ribosylation in response to DNA damage is still under debate. Here, the authors use ATR-FTIR spectroscopy to provide time-resolved insights into the molecular details of this process under near physiological conditions.Annika KrügerAlexander BürkleKarin HauserAswin MangerichNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Annika Krüger Alexander Bürkle Karin Hauser Aswin Mangerich Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy
description	The mechanism of PARP1-dependent poly-ADP-ribosylation in response to DNA damage is still under debate. Here, the authors use ATR-FTIR spectroscopy to provide time-resolved insights into the molecular details of this process under near physiological conditions.
format	article
author	Annika Krüger Alexander Bürkle Karin Hauser Aswin Mangerich
author_facet	Annika Krüger Alexander Bürkle Karin Hauser Aswin Mangerich
author_sort	Annika Krüger
title	Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy
title_short	Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy
title_full	Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy
title_fullStr	Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy
title_full_unstemmed	Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy
title_sort	real-time monitoring of parp1-dependent parylation by atr-ftir spectroscopy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1616d84778de4c2386df75ff6b8c0ab3
work_keys_str_mv	AT annikakruger realtimemonitoringofparp1dependentparylationbyatrftirspectroscopy AT alexanderburkle realtimemonitoringofparp1dependentparylationbyatrftirspectroscopy AT karinhauser realtimemonitoringofparp1dependentparylationbyatrftirspectroscopy AT aswinmangerich realtimemonitoringofparp1dependentparylationbyatrftirspectroscopy
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Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy

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