Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system
The gut microbiota may contribute to depression, but the underlying mechanism is not well understood. Here the authors use a mouse model of stress induced depression to demonstrate that behavioural changes conferred by fecal transplant from stressed to naïve mice require the endocannabinoid system.
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Nature Portfolio
2020
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oai:doaj.org-article:161cd6205c514a068009fecb2385aea82021-12-02T13:24:34ZEffect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system10.1038/s41467-020-19931-22041-1723https://doaj.org/article/161cd6205c514a068009fecb2385aea82020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19931-2https://doaj.org/toc/2041-1723The gut microbiota may contribute to depression, but the underlying mechanism is not well understood. Here the authors use a mouse model of stress induced depression to demonstrate that behavioural changes conferred by fecal transplant from stressed to naïve mice require the endocannabinoid system.Grégoire ChevalierEleni SiopiLaure Guenin-MacéMaud PascalThomas LavalAline RiffletIvo Gomperts BonecaCaroline DemangelBenoit ColschAlain PruvostEmeline Chu-VanAurélie MessagerFrançois LeulierGabriel LepousezGérard EberlPierre-Marie LledoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Grégoire Chevalier Eleni Siopi Laure Guenin-Macé Maud Pascal Thomas Laval Aline Rifflet Ivo Gomperts Boneca Caroline Demangel Benoit Colsch Alain Pruvost Emeline Chu-Van Aurélie Messager François Leulier Gabriel Lepousez Gérard Eberl Pierre-Marie Lledo Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system |
| description |
The gut microbiota may contribute to depression, but the underlying mechanism is not well understood. Here the authors use a mouse model of stress induced depression to demonstrate that behavioural changes conferred by fecal transplant from stressed to naïve mice require the endocannabinoid system. |
| format |
article |
| author |
Grégoire Chevalier Eleni Siopi Laure Guenin-Macé Maud Pascal Thomas Laval Aline Rifflet Ivo Gomperts Boneca Caroline Demangel Benoit Colsch Alain Pruvost Emeline Chu-Van Aurélie Messager François Leulier Gabriel Lepousez Gérard Eberl Pierre-Marie Lledo |
| author_facet |
Grégoire Chevalier Eleni Siopi Laure Guenin-Macé Maud Pascal Thomas Laval Aline Rifflet Ivo Gomperts Boneca Caroline Demangel Benoit Colsch Alain Pruvost Emeline Chu-Van Aurélie Messager François Leulier Gabriel Lepousez Gérard Eberl Pierre-Marie Lledo |
| author_sort |
Grégoire Chevalier |
| title |
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system |
| title_short |
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system |
| title_full |
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system |
| title_fullStr |
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system |
| title_full_unstemmed |
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system |
| title_sort |
effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/161cd6205c514a068009fecb2385aea8 |
| work_keys_str_mv |
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