ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C

Abstract. Present work is devoted to analyzing possible associations of single-nucleotide gene polymorphisms (SNPs) with liver pathology in patients with chronic hepatitis C. SNP genotypes and allele frequencies were identified for some genes of interferon system, i.e., oligoadenilatsynthetase-1 (-1...

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Autores principales:	V. A. Bychkov, N. V. Ryazantseva, V. V. Novitskiy, N. A. Semenova, L. A. Kleptsova, V. D. Yakushina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	chronic hepatitis c fibrosis oligoadenilatsynthetase-1 oligoadenilatsynthetase-3 protein kinase r Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1623ebfae9f34061ba7fcb2b13f28aab
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spelling	oai:doaj.org-article:1623ebfae9f34061ba7fcb2b13f28aab2021-11-18T08:03:39ZASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C1563-06252313-741X10.15789/1563-0625-2011-1-93-100https://doaj.org/article/1623ebfae9f34061ba7fcb2b13f28aab2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/266https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Present work is devoted to analyzing possible associations of single-nucleotide gene polymorphisms (SNPs) with liver pathology in patients with chronic hepatitis C. SNP genotypes and allele frequencies were identified for some genes of interferon system, i.e., oligoadenilatsynthetase-1 (-1A/G), oligoadenilatsynthetase-3 (+1314C/T), and protein kinase R (+244A/G), using DNA samples from healthy donors and patients with chronic hepatitis C representing population of Tomsk and Tomsk Region. An association has been shown between SNPs of oligoadenilatsynthetase-1 and protein kinase R genes, and clinical activity of inflammatory process in the liver, as well as an impact of certain SNPs of protein kinase R and oligoadenilatsynthetase-3 genes upon fibrogenesis. (Med. Immunol., 2011, vol. 13, N 1, pp 93-100)V. A. BychkovN. V. RyazantsevaV. V. NovitskiyN. A. SemenovaL. A. KleptsovaV. D. YakushinaSPb RAACIarticlechronic hepatitis cfibrosisoligoadenilatsynthetase-1oligoadenilatsynthetase-3protein kinase rImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 1, Pp 93-100 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic hepatitis c fibrosis oligoadenilatsynthetase-1 oligoadenilatsynthetase-3 protein kinase r Immunologic diseases. Allergy RC581-607
spellingShingle	chronic hepatitis c fibrosis oligoadenilatsynthetase-1 oligoadenilatsynthetase-3 protein kinase r Immunologic diseases. Allergy RC581-607 V. A. Bychkov N. V. Ryazantseva V. V. Novitskiy N. A. Semenova L. A. Kleptsova V. D. Yakushina ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C
description	Abstract. Present work is devoted to analyzing possible associations of single-nucleotide gene polymorphisms (SNPs) with liver pathology in patients with chronic hepatitis C. SNP genotypes and allele frequencies were identified for some genes of interferon system, i.e., oligoadenilatsynthetase-1 (-1A/G), oligoadenilatsynthetase-3 (+1314C/T), and protein kinase R (+244A/G), using DNA samples from healthy donors and patients with chronic hepatitis C representing population of Tomsk and Tomsk Region. An association has been shown between SNPs of oligoadenilatsynthetase-1 and protein kinase R genes, and clinical activity of inflammatory process in the liver, as well as an impact of certain SNPs of protein kinase R and oligoadenilatsynthetase-3 genes upon fibrogenesis. (Med. Immunol., 2011, vol. 13, N 1, pp 93-100)
format	article
author	V. A. Bychkov N. V. Ryazantseva V. V. Novitskiy N. A. Semenova L. A. Kleptsova V. D. Yakushina
author_facet	V. A. Bychkov N. V. Ryazantseva V. V. Novitskiy N. A. Semenova L. A. Kleptsova V. D. Yakushina
author_sort	V. A. Bychkov
title	ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C
title_short	ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C
title_full	ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C
title_fullStr	ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C
title_full_unstemmed	ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C
title_sort	associations of interferon gene polymorphisms oas-1, oas-3, pkr with chronic viral hepatitis c
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/1623ebfae9f34061ba7fcb2b13f28aab
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ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C

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