The Role of Pseudomonas aeruginosa Virulence Factors in Cytoskeletal Dysregulation and Lung Barrier Dysfunction

Pseudomonas (P.) aeruginosa is an opportunistic pathogen that causes serious infections and hospital-acquired pneumonia in immunocompromised patients. P. aeruginosa accounts for up to 20% of all cases of hospital-acquired pneumonia, with an attributable mortalit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Brant M. Wagener, Ruihan Hu, Songwei Wu, Jean-Francois Pittet, Qiang Ding, Pulin Che
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Pseudomonas aeruginosa</i> virulence factors actin cytoskeleton lung barrier integrity Medicine R
Acceso en línea:	https://doaj.org/article/1626237b927449d69dacde3be9a92005
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1626237b927449d69dacde3be9a92005
record_format	dspace
spelling	oai:doaj.org-article:1626237b927449d69dacde3be9a920052021-11-25T19:08:44ZThe Role of <i>Pseudomonas aeruginosa</i> Virulence Factors in Cytoskeletal Dysregulation and Lung Barrier Dysfunction10.3390/toxins131107762072-6651https://doaj.org/article/1626237b927449d69dacde3be9a920052021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6651/13/11/776https://doaj.org/toc/2072-6651<i>Pseudomonas (P.) aeruginosa</i> is an opportunistic pathogen that causes serious infections and hospital-acquired pneumonia in immunocompromised patients. <i>P. aeruginosa</i> accounts for up to 20% of all cases of hospital-acquired pneumonia, with an attributable mortality rate of ~30–40%. The poor clinical outcome of <i>P. aeruginosa</i>-induced pneumonia is ascribed to its ability to disrupt lung barrier integrity, leading to the development of lung edema and bacteremia. Airway epithelial and endothelial cells are important architecture blocks that protect the lung from invading pathogens. <i>P. aeruginosa</i> produces a number of virulence factors that can modulate barrier function, directly or indirectly, through exploiting cytoskeleton networks and intercellular junctional complexes in eukaryotic cells. This review summarizes the current knowledge on <i>P. aeruginosa</i> virulence factors, their effects on the regulation of the cytoskeletal network and associated components, and molecular mechanisms regulating barrier function in airway epithelial and endothelial cells. A better understanding of these processes will help to lay the foundation for new therapeutic approaches against <i>P. aeruginosa</i>-induced pneumonia.Brant M. WagenerRuihan HuSongwei WuJean-Francois PittetQiang DingPulin CheMDPI AGarticle<i>Pseudomonas aeruginosa</i>virulence factorsactin cytoskeletonlung barrier integrityMedicineRENToxins, Vol 13, Iss 776, p 776 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Pseudomonas aeruginosa</i> virulence factors actin cytoskeleton lung barrier integrity Medicine R
spellingShingle	<i>Pseudomonas aeruginosa</i> virulence factors actin cytoskeleton lung barrier integrity Medicine R Brant M. Wagener Ruihan Hu Songwei Wu Jean-Francois Pittet Qiang Ding Pulin Che The Role of <i>Pseudomonas aeruginosa</i> Virulence Factors in Cytoskeletal Dysregulation and Lung Barrier Dysfunction
description	<i>Pseudomonas (P.) aeruginosa</i> is an opportunistic pathogen that causes serious infections and hospital-acquired pneumonia in immunocompromised patients. <i>P. aeruginosa</i> accounts for up to 20% of all cases of hospital-acquired pneumonia, with an attributable mortality rate of ~30–40%. The poor clinical outcome of <i>P. aeruginosa</i>-induced pneumonia is ascribed to its ability to disrupt lung barrier integrity, leading to the development of lung edema and bacteremia. Airway epithelial and endothelial cells are important architecture blocks that protect the lung from invading pathogens. <i>P. aeruginosa</i> produces a number of virulence factors that can modulate barrier function, directly or indirectly, through exploiting cytoskeleton networks and intercellular junctional complexes in eukaryotic cells. This review summarizes the current knowledge on <i>P. aeruginosa</i> virulence factors, their effects on the regulation of the cytoskeletal network and associated components, and molecular mechanisms regulating barrier function in airway epithelial and endothelial cells. A better understanding of these processes will help to lay the foundation for new therapeutic approaches against <i>P. aeruginosa</i>-induced pneumonia.
format	article
author	Brant M. Wagener Ruihan Hu Songwei Wu Jean-Francois Pittet Qiang Ding Pulin Che
author_facet	Brant M. Wagener Ruihan Hu Songwei Wu Jean-Francois Pittet Qiang Ding Pulin Che
author_sort	Brant M. Wagener
title	The Role of <i>Pseudomonas aeruginosa</i> Virulence Factors in Cytoskeletal Dysregulation and Lung Barrier Dysfunction
title_short	The Role of <i>Pseudomonas aeruginosa</i> Virulence Factors in Cytoskeletal Dysregulation and Lung Barrier Dysfunction
title_full	The Role of <i>Pseudomonas aeruginosa</i> Virulence Factors in Cytoskeletal Dysregulation and Lung Barrier Dysfunction
title_fullStr	The Role of <i>Pseudomonas aeruginosa</i> Virulence Factors in Cytoskeletal Dysregulation and Lung Barrier Dysfunction
title_full_unstemmed	The Role of <i>Pseudomonas aeruginosa</i> Virulence Factors in Cytoskeletal Dysregulation and Lung Barrier Dysfunction
title_sort	role of <i>pseudomonas aeruginosa</i> virulence factors in cytoskeletal dysregulation and lung barrier dysfunction
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1626237b927449d69dacde3be9a92005
work_keys_str_mv	AT brantmwagener theroleofipseudomonasaeruginosaivirulencefactorsincytoskeletaldysregulationandlungbarrierdysfunction AT ruihanhu theroleofipseudomonasaeruginosaivirulencefactorsincytoskeletaldysregulationandlungbarrierdysfunction AT songweiwu theroleofipseudomonasaeruginosaivirulencefactorsincytoskeletaldysregulationandlungbarrierdysfunction AT jeanfrancoispittet theroleofipseudomonasaeruginosaivirulencefactorsincytoskeletaldysregulationandlungbarrierdysfunction AT qiangding theroleofipseudomonasaeruginosaivirulencefactorsincytoskeletaldysregulationandlungbarrierdysfunction AT pulinche theroleofipseudomonasaeruginosaivirulencefactorsincytoskeletaldysregulationandlungbarrierdysfunction AT brantmwagener roleofipseudomonasaeruginosaivirulencefactorsincytoskeletaldysregulationandlungbarrierdysfunction AT ruihanhu roleofipseudomonasaeruginosaivirulencefactorsincytoskeletaldysregulationandlungbarrierdysfunction AT songweiwu roleofipseudomonasaeruginosaivirulencefactorsincytoskeletaldysregulationandlungbarrierdysfunction AT jeanfrancoispittet roleofipseudomonasaeruginosaivirulencefactorsincytoskeletaldysregulationandlungbarrierdysfunction AT qiangding roleofipseudomonasaeruginosaivirulencefactorsincytoskeletaldysregulationandlungbarrierdysfunction AT pulinche roleofipseudomonasaeruginosaivirulencefactorsincytoskeletaldysregulationandlungbarrierdysfunction
_version_	1718410199810703360

The Role of <i>Pseudomonas aeruginosa</i> Virulence Factors in Cytoskeletal Dysregulation and Lung Barrier Dysfunction

Ejemplares similares