Chapter 14: Cancer genome analysis.

Although there is great promise in the benefits to be obtained by analyzing cancer genomes, numerous challenges hinder different stages of the process, from the problem of sample preparation and the validation of the experimental techniques, to the interpretation of the results. This chapter specifi...

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Autores principales: Miguel Vazquez, Victor de la Torre, Alfonso Valencia
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Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/162629e261424f2381fb27087d7d7ac9
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spelling oai:doaj.org-article:162629e261424f2381fb27087d7d7ac92021-11-18T05:52:35ZChapter 14: Cancer genome analysis.1553-734X1553-735810.1371/journal.pcbi.1002824https://doaj.org/article/162629e261424f2381fb27087d7d7ac92012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300415/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Although there is great promise in the benefits to be obtained by analyzing cancer genomes, numerous challenges hinder different stages of the process, from the problem of sample preparation and the validation of the experimental techniques, to the interpretation of the results. This chapter specifically focuses on the technical issues associated with the bioinformatics analysis of cancer genome data. The main issues addressed are the use of database and software resources, the use of analysis workflows and the presentation of clinically relevant action items. We attempt to aid new developers in the field by describing the different stages of analysis and discussing current approaches, as well as by providing practical advice on how to access and use resources, and how to implement recommendations. Real cases from cancer genome projects are used as examples.Miguel VazquezVictor de la TorreAlfonso ValenciaPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 12, p e1002824 (2012)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Miguel Vazquez
Victor de la Torre
Alfonso Valencia
Chapter 14: Cancer genome analysis.
description Although there is great promise in the benefits to be obtained by analyzing cancer genomes, numerous challenges hinder different stages of the process, from the problem of sample preparation and the validation of the experimental techniques, to the interpretation of the results. This chapter specifically focuses on the technical issues associated with the bioinformatics analysis of cancer genome data. The main issues addressed are the use of database and software resources, the use of analysis workflows and the presentation of clinically relevant action items. We attempt to aid new developers in the field by describing the different stages of analysis and discussing current approaches, as well as by providing practical advice on how to access and use resources, and how to implement recommendations. Real cases from cancer genome projects are used as examples.
format article
author Miguel Vazquez
Victor de la Torre
Alfonso Valencia
author_facet Miguel Vazquez
Victor de la Torre
Alfonso Valencia
author_sort Miguel Vazquez
title Chapter 14: Cancer genome analysis.
title_short Chapter 14: Cancer genome analysis.
title_full Chapter 14: Cancer genome analysis.
title_fullStr Chapter 14: Cancer genome analysis.
title_full_unstemmed Chapter 14: Cancer genome analysis.
title_sort chapter 14: cancer genome analysis.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/162629e261424f2381fb27087d7d7ac9
work_keys_str_mv AT miguelvazquez chapter14cancergenomeanalysis
AT victordelatorre chapter14cancergenomeanalysis
AT alfonsovalencia chapter14cancergenomeanalysis
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