PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport

The kinesin-3 KIF1C transports dense core vesicles in neurons and delivers integrins to cell adhesions sites. Here the authors show that KIF1C's autoinhibitory interactions are released upon binding of protein tyrosine phosphatase PTPN21 or cargo adapter Hook3 resulting in cargo-activated trans...

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Autores principales:	Nida Siddiqui, Alexander James Zwetsloot, Alice Bachmann, Daniel Roth, Hamdi Hussain, Jonathan Brandt, Irina Kaverina, Anne Straube
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/162a6e1c7f5f47188ce4d4933ccacadd
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spelling	oai:doaj.org-article:162a6e1c7f5f47188ce4d4933ccacadd2021-12-02T16:50:59ZPTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport10.1038/s41467-019-10644-92041-1723https://doaj.org/article/162a6e1c7f5f47188ce4d4933ccacadd2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10644-9https://doaj.org/toc/2041-1723The kinesin-3 KIF1C transports dense core vesicles in neurons and delivers integrins to cell adhesions sites. Here the authors show that KIF1C's autoinhibitory interactions are released upon binding of protein tyrosine phosphatase PTPN21 or cargo adapter Hook3 resulting in cargo-activated transport.Nida SiddiquiAlexander James ZwetslootAlice BachmannDaniel RothHamdi HussainJonathan BrandtIrina KaverinaAnne StraubeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nida Siddiqui Alexander James Zwetsloot Alice Bachmann Daniel Roth Hamdi Hussain Jonathan Brandt Irina Kaverina Anne Straube PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport
description	The kinesin-3 KIF1C transports dense core vesicles in neurons and delivers integrins to cell adhesions sites. Here the authors show that KIF1C's autoinhibitory interactions are released upon binding of protein tyrosine phosphatase PTPN21 or cargo adapter Hook3 resulting in cargo-activated transport.
format	article
author	Nida Siddiqui Alexander James Zwetsloot Alice Bachmann Daniel Roth Hamdi Hussain Jonathan Brandt Irina Kaverina Anne Straube
author_facet	Nida Siddiqui Alexander James Zwetsloot Alice Bachmann Daniel Roth Hamdi Hussain Jonathan Brandt Irina Kaverina Anne Straube
author_sort	Nida Siddiqui
title	PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport
title_short	PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport
title_full	PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport
title_fullStr	PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport
title_full_unstemmed	PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport
title_sort	ptpn21 and hook3 relieve kif1c autoinhibition and activate intracellular transport
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/162a6e1c7f5f47188ce4d4933ccacadd
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PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport

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