Risk and outcomes of diabetes in patients with epilepsy

Abstract The risk and outcomes of diabetes in patients with epilepsy remains unclear. We evaluated these risks using an epilepsy cohort analysis and a diabetes admission analysis. In the epilepsy cohort analysis, we identified 2854 patients with newly diagnosed epilepsy in 2000–2008 from the researc...

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Autores principales:	Chun-Cheng Li, Chuen-Chau Chang, Yih-Giun Cherng, Chao-Shun Lin, Chun-Chieh Yeh, Yi-Cheng Chang, Chaur-Jong Hu, Chun-Chuan Shih, Ta-Liang Chen, Chien-Chang Liao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/162ac3a8b4064aa996c8d64cb126ec5d
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spelling	oai:doaj.org-article:162ac3a8b4064aa996c8d64cb126ec5d2021-12-02T18:48:23ZRisk and outcomes of diabetes in patients with epilepsy10.1038/s41598-021-98340-x2045-2322https://doaj.org/article/162ac3a8b4064aa996c8d64cb126ec5d2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98340-xhttps://doaj.org/toc/2045-2322Abstract The risk and outcomes of diabetes in patients with epilepsy remains unclear. We evaluated these risks using an epilepsy cohort analysis and a diabetes admission analysis. In the epilepsy cohort analysis, we identified 2854 patients with newly diagnosed epilepsy in 2000–2008 from the research data of National Health Insurance in Taiwan. Using Propensity-score matching by sociodemographic factors and medical conditions, we selected 22,832 people without epilepsy as a non-exposed cohort for comparison. Follow-up events of diabetes from January 1, 2000 until December 31, 2013 were ascertained from medical claims. The adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of diabetes associated with epilepsy were calculated using multiple Cox proportional hazard models. In the diabetes admission analysis, we identified 92,438 hospitalized diabetes patients, 930 of whom had a history of epilepsy. Adjusted odds ratios (ORs) and 95% CIs of adverse events after diabetes associated with previous epilepsy were calculated using multiple logistic regressions. The adjusted HR of diabetes in the cohort with epilepsy was 1.31 (95% CI 1.14–1.50) compared to the non-epilepsy cohort. Previous epilepsy was associated with post-diabetes adverse events, such as pneumonia (OR 1.68, 95% CI 1.37–2.07), urinary tract infection (OR 1.83, 95% CI 1.55–2.16), and septicemia (OR 1.34, 95% CI 1.09–1.65). In conclusion, epilepsy was associated with higher risk of diabetes and adverse post-diabetes outcomes. Diabetes prevention and attention to post-diabetes adverse events are needed for this susceptible population.Chun-Cheng LiChuen-Chau ChangYih-Giun CherngChao-Shun LinChun-Chieh YehYi-Cheng ChangChaur-Jong HuChun-Chuan ShihTa-Liang ChenChien-Chang LiaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chun-Cheng Li Chuen-Chau Chang Yih-Giun Cherng Chao-Shun Lin Chun-Chieh Yeh Yi-Cheng Chang Chaur-Jong Hu Chun-Chuan Shih Ta-Liang Chen Chien-Chang Liao Risk and outcomes of diabetes in patients with epilepsy
description	Abstract The risk and outcomes of diabetes in patients with epilepsy remains unclear. We evaluated these risks using an epilepsy cohort analysis and a diabetes admission analysis. In the epilepsy cohort analysis, we identified 2854 patients with newly diagnosed epilepsy in 2000–2008 from the research data of National Health Insurance in Taiwan. Using Propensity-score matching by sociodemographic factors and medical conditions, we selected 22,832 people without epilepsy as a non-exposed cohort for comparison. Follow-up events of diabetes from January 1, 2000 until December 31, 2013 were ascertained from medical claims. The adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of diabetes associated with epilepsy were calculated using multiple Cox proportional hazard models. In the diabetes admission analysis, we identified 92,438 hospitalized diabetes patients, 930 of whom had a history of epilepsy. Adjusted odds ratios (ORs) and 95% CIs of adverse events after diabetes associated with previous epilepsy were calculated using multiple logistic regressions. The adjusted HR of diabetes in the cohort with epilepsy was 1.31 (95% CI 1.14–1.50) compared to the non-epilepsy cohort. Previous epilepsy was associated with post-diabetes adverse events, such as pneumonia (OR 1.68, 95% CI 1.37–2.07), urinary tract infection (OR 1.83, 95% CI 1.55–2.16), and septicemia (OR 1.34, 95% CI 1.09–1.65). In conclusion, epilepsy was associated with higher risk of diabetes and adverse post-diabetes outcomes. Diabetes prevention and attention to post-diabetes adverse events are needed for this susceptible population.
format	article
author	Chun-Cheng Li Chuen-Chau Chang Yih-Giun Cherng Chao-Shun Lin Chun-Chieh Yeh Yi-Cheng Chang Chaur-Jong Hu Chun-Chuan Shih Ta-Liang Chen Chien-Chang Liao
author_facet	Chun-Cheng Li Chuen-Chau Chang Yih-Giun Cherng Chao-Shun Lin Chun-Chieh Yeh Yi-Cheng Chang Chaur-Jong Hu Chun-Chuan Shih Ta-Liang Chen Chien-Chang Liao
author_sort	Chun-Cheng Li
title	Risk and outcomes of diabetes in patients with epilepsy
title_short	Risk and outcomes of diabetes in patients with epilepsy
title_full	Risk and outcomes of diabetes in patients with epilepsy
title_fullStr	Risk and outcomes of diabetes in patients with epilepsy
title_full_unstemmed	Risk and outcomes of diabetes in patients with epilepsy
title_sort	risk and outcomes of diabetes in patients with epilepsy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/162ac3a8b4064aa996c8d64cb126ec5d
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_version_	1718377606498222080

Risk and outcomes of diabetes in patients with epilepsy

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