Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol

Blanca Olivia Murillo Ortiz,1 Alma Rosa Fuentes Preciado,2 Joel Ramírez Emiliano,2 Sandra Martínez Garza,1 Edna Ramos Rodríguez,3 Luz Angélica de Alba Macías2 1Clinical Epidemiology Research Unit, UMAE No. 1 Bajio, Mexican Institute Social Secur...

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Autores principales:	Murillo Ortiz BO, Fuentes Preciado AR, Ramírez Emiliano J, Martínez Garza S, Ramos Rodríguez E, de Alba Macías L.A.
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	curcumin resveratrol chronic kidney disease recovery of bone and muscle mass. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/162c8c224a2d4c09ae10f5f01a873ecd
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spelling	oai:doaj.org-article:162c8c224a2d4c09ae10f5f01a873ecd2021-12-02T10:42:06ZRecovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol1178-1998https://doaj.org/article/162c8c224a2d4c09ae10f5f01a873ecd2019-11-01T00:00:00Zhttps://www.dovepress.com/recovery-of-bone-and-muscle-mass-in-patients-with-chronic-kidney-disea-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Blanca Olivia Murillo Ortiz,1 Alma Rosa Fuentes Preciado,2 Joel Ramírez Emiliano,2 Sandra Martínez Garza,1 Edna Ramos Rodríguez,3 Luz Angélica de Alba Macías2 1Clinical Epidemiology Research Unit, UMAE No. 1 Bajio, Mexican Institute Social Security, León, Guanajuato, Mexico; 2Department of Medical Sciences, University of Guanajuato, León, Guanajuato, Mexico; 3Regional General Hospital No. 58, Mexican Institute Social Security, León, Guanajuato, MexicoCorrespondence: Blanca Olivia Murillo OrtizUnidad de Investigación en Epidemiología Clínica, Unidad Médica de Alta Especialidad No. 1 Bajío, Instituto Mexicano del Seguro Social, Boulevard López Mateos e Insurgentes s/n, Colonia Los Paraísos, León, Guanajuato, MéxicoTel/Fax +52 4777183039Email bomo907@hotmail.comIntroduction: Malnutrition is common in haemodialysis patients and closely related to morbidity and mortality. We evaluated the effect of twelve weeks of supplementation with resveratrol and curcumin on recovery of bone and muscle mass and protein oxidation, lipid peroxidation on patients with chronic kidney disease and iron overload undergoing hemodialysis, we performed a randomized, double-blind, placebo-controlled trial.Methods: We included a total of 40 patients, were randomly assigned to two groups, 20 to the group with antioxidant supplementation (Resveratrol + Curcumin) (Group A), treated with a daily oral dose of 500 mg of Resveratrol and 500 mg of Curcumin, and 20 to the control group treated with placebo (Group B).Results: Significant differences were found in the body composition of the patients between both groups. There was a significant difference in Body Mass Index (BMI) values (p = 0.002), fat percentage (p = 0.007), muscle mass (p = 0.01) bone mass (p = 0.01), as well as in the score of the subjective global evaluation (p = 0.03). Also differences were found between the basal and final serum levels of Triglycerides (TG) (p = 0.01), VLDL (p = 0.003). A significant decrease in the levels of serum ferritin (2003.69 ± 518.73 vs 1795.65 ± 519.00 ng/mL; p = 0.04). Nor were significant differences observed between the baseline and the final Thiobarbituric Acid Reactive Substances (TBARS) values (70.45 ± 69.21 vs 50.19 ± 32.62, p = 0.24). The same results was obtained for carbonyl values (2.67 ± 0.75 vs 2.50 ± 0.85; p = 0.50).Discussion: The present study is the first assay on patients with chronic kidney disease and iron overload that demonstrates the beneficial effects of combined supplementation with Curcumin and Resveratrol on muscle and bone mass. There was a significant decrease in circulating levels of ferritin, to finding that remarkably novel.Keywords: curcumin, resveratrol, chronic kidney disease, recovery of bone and muscle massMurillo Ortiz BOFuentes Preciado ARRamírez Emiliano JMartínez Garza SRamos Rodríguez Ede Alba Macías L.A.Dove Medical Pressarticlecurcuminresveratrolchronic kidney diseaserecovery of bone and muscle mass.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 2055-2062 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	curcumin resveratrol chronic kidney disease recovery of bone and muscle mass. Geriatrics RC952-954.6
spellingShingle	curcumin resveratrol chronic kidney disease recovery of bone and muscle mass. Geriatrics RC952-954.6 Murillo Ortiz BO Fuentes Preciado AR Ramírez Emiliano J Martínez Garza S Ramos Rodríguez E de Alba Macías L.A. Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol
description	Blanca Olivia Murillo Ortiz,1 Alma Rosa Fuentes Preciado,2 Joel Ramírez Emiliano,2 Sandra Martínez Garza,1 Edna Ramos Rodríguez,3 Luz Angélica de Alba Macías2 1Clinical Epidemiology Research Unit, UMAE No. 1 Bajio, Mexican Institute Social Security, León, Guanajuato, Mexico; 2Department of Medical Sciences, University of Guanajuato, León, Guanajuato, Mexico; 3Regional General Hospital No. 58, Mexican Institute Social Security, León, Guanajuato, MexicoCorrespondence: Blanca Olivia Murillo OrtizUnidad de Investigación en Epidemiología Clínica, Unidad Médica de Alta Especialidad No. 1 Bajío, Instituto Mexicano del Seguro Social, Boulevard López Mateos e Insurgentes s/n, Colonia Los Paraísos, León, Guanajuato, MéxicoTel/Fax +52 4777183039Email bomo907@hotmail.comIntroduction: Malnutrition is common in haemodialysis patients and closely related to morbidity and mortality. We evaluated the effect of twelve weeks of supplementation with resveratrol and curcumin on recovery of bone and muscle mass and protein oxidation, lipid peroxidation on patients with chronic kidney disease and iron overload undergoing hemodialysis, we performed a randomized, double-blind, placebo-controlled trial.Methods: We included a total of 40 patients, were randomly assigned to two groups, 20 to the group with antioxidant supplementation (Resveratrol + Curcumin) (Group A), treated with a daily oral dose of 500 mg of Resveratrol and 500 mg of Curcumin, and 20 to the control group treated with placebo (Group B).Results: Significant differences were found in the body composition of the patients between both groups. There was a significant difference in Body Mass Index (BMI) values (p = 0.002), fat percentage (p = 0.007), muscle mass (p = 0.01) bone mass (p = 0.01), as well as in the score of the subjective global evaluation (p = 0.03). Also differences were found between the basal and final serum levels of Triglycerides (TG) (p = 0.01), VLDL (p = 0.003). A significant decrease in the levels of serum ferritin (2003.69 ± 518.73 vs 1795.65 ± 519.00 ng/mL; p = 0.04). Nor were significant differences observed between the baseline and the final Thiobarbituric Acid Reactive Substances (TBARS) values (70.45 ± 69.21 vs 50.19 ± 32.62, p = 0.24). The same results was obtained for carbonyl values (2.67 ± 0.75 vs 2.50 ± 0.85; p = 0.50).Discussion: The present study is the first assay on patients with chronic kidney disease and iron overload that demonstrates the beneficial effects of combined supplementation with Curcumin and Resveratrol on muscle and bone mass. There was a significant decrease in circulating levels of ferritin, to finding that remarkably novel.Keywords: curcumin, resveratrol, chronic kidney disease, recovery of bone and muscle mass
format	article
author	Murillo Ortiz BO Fuentes Preciado AR Ramírez Emiliano J Martínez Garza S Ramos Rodríguez E de Alba Macías L.A.
author_facet	Murillo Ortiz BO Fuentes Preciado AR Ramírez Emiliano J Martínez Garza S Ramos Rodríguez E de Alba Macías L.A.
author_sort	Murillo Ortiz BO
title	Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol
title_short	Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol
title_full	Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol
title_fullStr	Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol
title_full_unstemmed	Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol
title_sort	recovery of bone and muscle mass in patients with chronic kidney disease and iron overload on hemodialysis and taking combined supplementation with curcumin and resveratrol
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/162c8c224a2d4c09ae10f5f01a873ecd
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Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol

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