COGNITIVE IMPAIRMENT DETECTION IN ADULT THALASSEMIA PATIENT USING MOCA-INA

Background: Cognitive impairment in thalassemia patients are prevalent, therefore early detection of cognitive impairment in adult thalassemia patients is crucial for prevention. Montreal Cognitive Assessment (MoCA) is a public domain cognition screening tools that covers all cognitive domains in de...

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Autores principales:	Chandra Calista Wardoyo, Uni Gamayani, Anam Ong, Ahmad Rizal, Yusuf Wibisono, Lisda Amalia, Ramdan Panigoro, Pandji Irani Fiaza
Formato:	article
Lenguaje:	EN ID
Publicado:	University of Brawijaya 2021
Materias:	cognitive function moca-ina thalassemia Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/162cbcef0d384cdc90b6ac6dd01978c4
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spelling	oai:doaj.org-article:162cbcef0d384cdc90b6ac6dd01978c42021-11-23T03:03:03Z COGNITIVE IMPAIRMENT DETECTION IN ADULT THALASSEMIA PATIENT USING MOCA-INA10.21776/ub.mnj.2021.007.01.62407-67242442-5001https://doaj.org/article/162cbcef0d384cdc90b6ac6dd01978c42021-01-01T00:00:00Zhttps://mnj.ub.ac.id/index.php/mnj/article/view/467https://doaj.org/toc/2407-6724https://doaj.org/toc/2442-5001Background: Cognitive impairment in thalassemia patients are prevalent, therefore early detection of cognitive impairment in adult thalassemia patients is crucial for prevention. Montreal Cognitive Assessment (MoCA) is a public domain cognition screening tools that covers all cognitive domains in detecting mild cognitive impairments. Objective: To compare cognitive function between adult thalassemia patients and healty control by using Indonesia version of MoCA test (MoCA-Ina) Methods: This prospective observational analytic with case control study, compared the total scores and scores of each domain of cognition between adult thalassemia patients and healthy subjects at the Medical Hematology Oncology Clinic of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia using MoCA-Ina from August to October 2018. Results: A total of 32 thalassemia subjects and 50 healthy subjects were conducted. A total of 16(50%) subjects in the case group had a value of MoCA-Ina <26, while only 1(2%) healthy control had a value of MoCA-Ina <26. The median total MoCA-Ina score in case and control groups were 25.5 and 27.50 (p <0.001). The median score of memory domains, executive functions and visuospatial of the case and control groups were 3 versus 4 (p <0.001), 3 versus 3.5 (p <0.001) and 3.53 ± 0.671 versus 3.88 ± 0.385 (p <0.003), respectively. Conclusion: Adults thalassemia patients have lower score in total MoCA-Ina, domains of memory, executive function and visuospatial score compared to healthy control.Chandra Calista WardoyoUni GamayaniAnam OngAhmad RizalYusuf WibisonoLisda AmaliaRamdan PanigoroPandji Irani FiazaUniversity of Brawijayaarticlecognitive functionmoca-inathalassemiaMedicineRNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENIDMalang Neurology Journal, Vol 7, Iss 1, Pp 24-29 (2021)
institution	DOAJ
collection	DOAJ
language	EN ID
topic	cognitive function moca-ina thalassemia Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	cognitive function moca-ina thalassemia Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Chandra Calista Wardoyo Uni Gamayani Anam Ong Ahmad Rizal Yusuf Wibisono Lisda Amalia Ramdan Panigoro Pandji Irani Fiaza COGNITIVE IMPAIRMENT DETECTION IN ADULT THALASSEMIA PATIENT USING MOCA-INA
description	Background: Cognitive impairment in thalassemia patients are prevalent, therefore early detection of cognitive impairment in adult thalassemia patients is crucial for prevention. Montreal Cognitive Assessment (MoCA) is a public domain cognition screening tools that covers all cognitive domains in detecting mild cognitive impairments. Objective: To compare cognitive function between adult thalassemia patients and healty control by using Indonesia version of MoCA test (MoCA-Ina) Methods: This prospective observational analytic with case control study, compared the total scores and scores of each domain of cognition between adult thalassemia patients and healthy subjects at the Medical Hematology Oncology Clinic of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia using MoCA-Ina from August to October 2018. Results: A total of 32 thalassemia subjects and 50 healthy subjects were conducted. A total of 16(50%) subjects in the case group had a value of MoCA-Ina <26, while only 1(2%) healthy control had a value of MoCA-Ina <26. The median total MoCA-Ina score in case and control groups were 25.5 and 27.50 (p <0.001). The median score of memory domains, executive functions and visuospatial of the case and control groups were 3 versus 4 (p <0.001), 3 versus 3.5 (p <0.001) and 3.53 ± 0.671 versus 3.88 ± 0.385 (p <0.003), respectively. Conclusion: Adults thalassemia patients have lower score in total MoCA-Ina, domains of memory, executive function and visuospatial score compared to healthy control.
format	article
author	Chandra Calista Wardoyo Uni Gamayani Anam Ong Ahmad Rizal Yusuf Wibisono Lisda Amalia Ramdan Panigoro Pandji Irani Fiaza
author_facet	Chandra Calista Wardoyo Uni Gamayani Anam Ong Ahmad Rizal Yusuf Wibisono Lisda Amalia Ramdan Panigoro Pandji Irani Fiaza
author_sort	Chandra Calista Wardoyo
title	COGNITIVE IMPAIRMENT DETECTION IN ADULT THALASSEMIA PATIENT USING MOCA-INA
title_short	COGNITIVE IMPAIRMENT DETECTION IN ADULT THALASSEMIA PATIENT USING MOCA-INA
title_full	COGNITIVE IMPAIRMENT DETECTION IN ADULT THALASSEMIA PATIENT USING MOCA-INA
title_fullStr	COGNITIVE IMPAIRMENT DETECTION IN ADULT THALASSEMIA PATIENT USING MOCA-INA
title_full_unstemmed	COGNITIVE IMPAIRMENT DETECTION IN ADULT THALASSEMIA PATIENT USING MOCA-INA
title_sort	cognitive impairment detection in adult thalassemia patient using moca-ina
publisher	University of Brawijaya
publishDate	2021
url	https://doaj.org/article/162cbcef0d384cdc90b6ac6dd01978c4
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COGNITIVE IMPAIRMENT DETECTION IN ADULT THALASSEMIA PATIENT USING MOCA-INA

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