The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells

The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells

Abstract Tumor hypoxia and the hypoxia inducible factor-1, HIF-1, play critical roles in cancer progression and metastasis. We previously showed that hypoxia activates the endosomal GTPase Rab5, leading to tumor cell migration and invasion, and that these events do not involve changes in Rab protein...

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Autores principales: Solange Rivas, Patricio Silva, Montserrat Reyes, Hugo Sepúlveda, Luis Solano, Juan Acuña, Marisol Guerrero, Manuel Varas-Godoy, Andrew F. G. Quest, Martín Montecino, Vicente A. Torres
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/162d2f8285b346ffa6b8d60dcfde1d70
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