TRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion.

Adrenomedullin (AM) is a 52-amino acid peptide initially isolated from human pheochromocytoma. AM is expressed in a variety of malignant tissues and cancer cell lines and was shown to be a mitogenic factor capable of stimulating growth of several cancer cell types. In addition, AM is a survival fact...

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Autores principales:	Agathe Oulidi, Alexandre Bokhobza, Dimitra Gkika, Fabien Vanden Abeele, V'yacheslav Lehen'kyi, L'houcine Ouafik, Brigitte Mauroy, Natalia Prevarskaya
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/162dc005d7224f888567a07999661e11
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spelling	oai:doaj.org-article:162dc005d7224f888567a07999661e112021-11-18T07:43:32ZTRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion.1932-620310.1371/journal.pone.0064885https://doaj.org/article/162dc005d7224f888567a07999661e112013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23741410/?tool=EBIhttps://doaj.org/toc/1932-6203Adrenomedullin (AM) is a 52-amino acid peptide initially isolated from human pheochromocytoma. AM is expressed in a variety of malignant tissues and cancer cell lines and was shown to be a mitogenic factor capable of stimulating growth of several cancer cell types. In addition, AM is a survival factor for certain cancer cells. Some data suggest that AM might be involved in the progression cancer metastasis via angiogenesis and cell migration and invasion control. The Transient Receptor Potential channel TRPV2 is known to promote in prostate cancer cell migration and invasive phenotype and is correlated with the stage and grade of bladder cancer. In this work we show that AM induces prostate and urothelial cancer cell migration and invasion through TRPV2 translocation to plasma membrane and the subsequent increase in resting calcium level.Agathe OulidiAlexandre BokhobzaDimitra GkikaFabien Vanden AbeeleV'yacheslav Lehen'kyiL'houcine OuafikBrigitte MauroyNatalia PrevarskayaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e64885 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Agathe Oulidi Alexandre Bokhobza Dimitra Gkika Fabien Vanden Abeele V'yacheslav Lehen'kyi L'houcine Ouafik Brigitte Mauroy Natalia Prevarskaya TRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion.
description	Adrenomedullin (AM) is a 52-amino acid peptide initially isolated from human pheochromocytoma. AM is expressed in a variety of malignant tissues and cancer cell lines and was shown to be a mitogenic factor capable of stimulating growth of several cancer cell types. In addition, AM is a survival factor for certain cancer cells. Some data suggest that AM might be involved in the progression cancer metastasis via angiogenesis and cell migration and invasion control. The Transient Receptor Potential channel TRPV2 is known to promote in prostate cancer cell migration and invasive phenotype and is correlated with the stage and grade of bladder cancer. In this work we show that AM induces prostate and urothelial cancer cell migration and invasion through TRPV2 translocation to plasma membrane and the subsequent increase in resting calcium level.
format	article
author	Agathe Oulidi Alexandre Bokhobza Dimitra Gkika Fabien Vanden Abeele V'yacheslav Lehen'kyi L'houcine Ouafik Brigitte Mauroy Natalia Prevarskaya
author_facet	Agathe Oulidi Alexandre Bokhobza Dimitra Gkika Fabien Vanden Abeele V'yacheslav Lehen'kyi L'houcine Ouafik Brigitte Mauroy Natalia Prevarskaya
author_sort	Agathe Oulidi
title	TRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion.
title_short	TRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion.
title_full	TRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion.
title_fullStr	TRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion.
title_full_unstemmed	TRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion.
title_sort	trpv2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/162dc005d7224f888567a07999661e11
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TRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion.

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