Distinct RPA domains promote recruitment and the helicase-nuclease activities of Dna2

An enzymatic ensemble including Dna2 functions in DNA end resection; the function of the single-stranded DNA binding protein RPA in this complex has been underappreciated. Here the authors employ molecular modeling, biochemistry, and single molecule biophysics to reveal RPA directly promotes Dna2 re...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ananya Acharya, Kristina Kasaciunaite, Martin Göse, Vera Kissling, Raphaël Guérois, Ralf Seidel, Petr Cejka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/16301d9e71ec45368e5e40419da3144f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:16301d9e71ec45368e5e40419da3144f
record_format	dspace
spelling	oai:doaj.org-article:16301d9e71ec45368e5e40419da3144f2021-11-14T12:34:33ZDistinct RPA domains promote recruitment and the helicase-nuclease activities of Dna210.1038/s41467-021-26863-y2041-1723https://doaj.org/article/16301d9e71ec45368e5e40419da3144f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26863-yhttps://doaj.org/toc/2041-1723An enzymatic ensemble including Dna2 functions in DNA end resection; the function of the single-stranded DNA binding protein RPA in this complex has been underappreciated. Here the authors employ molecular modeling, biochemistry, and single molecule biophysics to reveal RPA directly promotes Dna2 recruitment, nuclease and helicase activities.Ananya AcharyaKristina KasaciunaiteMartin GöseVera KisslingRaphaël GuéroisRalf SeidelPetr CejkaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ananya Acharya Kristina Kasaciunaite Martin Göse Vera Kissling Raphaël Guérois Ralf Seidel Petr Cejka Distinct RPA domains promote recruitment and the helicase-nuclease activities of Dna2
description	An enzymatic ensemble including Dna2 functions in DNA end resection; the function of the single-stranded DNA binding protein RPA in this complex has been underappreciated. Here the authors employ molecular modeling, biochemistry, and single molecule biophysics to reveal RPA directly promotes Dna2 recruitment, nuclease and helicase activities.
format	article
author	Ananya Acharya Kristina Kasaciunaite Martin Göse Vera Kissling Raphaël Guérois Ralf Seidel Petr Cejka
author_facet	Ananya Acharya Kristina Kasaciunaite Martin Göse Vera Kissling Raphaël Guérois Ralf Seidel Petr Cejka
author_sort	Ananya Acharya
title	Distinct RPA domains promote recruitment and the helicase-nuclease activities of Dna2
title_short	Distinct RPA domains promote recruitment and the helicase-nuclease activities of Dna2
title_full	Distinct RPA domains promote recruitment and the helicase-nuclease activities of Dna2
title_fullStr	Distinct RPA domains promote recruitment and the helicase-nuclease activities of Dna2
title_full_unstemmed	Distinct RPA domains promote recruitment and the helicase-nuclease activities of Dna2
title_sort	distinct rpa domains promote recruitment and the helicase-nuclease activities of dna2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/16301d9e71ec45368e5e40419da3144f
work_keys_str_mv	AT ananyaacharya distinctrpadomainspromoterecruitmentandthehelicasenucleaseactivitiesofdna2 AT kristinakasaciunaite distinctrpadomainspromoterecruitmentandthehelicasenucleaseactivitiesofdna2 AT martingose distinctrpadomainspromoterecruitmentandthehelicasenucleaseactivitiesofdna2 AT verakissling distinctrpadomainspromoterecruitmentandthehelicasenucleaseactivitiesofdna2 AT raphaelguerois distinctrpadomainspromoterecruitmentandthehelicasenucleaseactivitiesofdna2 AT ralfseidel distinctrpadomainspromoterecruitmentandthehelicasenucleaseactivitiesofdna2 AT petrcejka distinctrpadomainspromoterecruitmentandthehelicasenucleaseactivitiesofdna2
_version_	1718429091645882368

Distinct RPA domains promote recruitment and the helicase-nuclease activities of Dna2

Ejemplares similares