Distinct RPA domains promote recruitment and the helicase-nuclease activities of Dna2
An enzymatic ensemble including Dna2 functions in DNA end resection; the function of the single-stranded DNA binding protein RPA in this complex has been underappreciated. Here the authors employ molecular modeling, biochemistry, and single molecule biophysics to reveal RPA directly promotes Dna2 re...
Guardado en:
Autores principales: | Ananya Acharya, Kristina Kasaciunaite, Martin Göse, Vera Kissling, Raphaël Guérois, Ralf Seidel, Petr Cejka |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/16301d9e71ec45368e5e40419da3144f |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase
por: Hazal B. Kose, et al.
Publicado: (2020) -
Molecular basis for PrimPol recruitment to replication forks by RPA
por: Thomas A. Guilliam, et al.
Publicado: (2017) -
The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs
por: Mahesh Lingaraju, et al.
Publicado: (2019) -
Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components
por: Michal Razew, et al.
Publicado: (2018) -
MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
por: Jen-Wei Huang, et al.
Publicado: (2020)