Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer
Defects in homologous recombination (HR) are found in some triple negative breast cancers, suggesting they may be sensitive to PARP inhibitors. In this phase II clinical trial of the PARP inhibitor rucaparib, changes in Ki67 levels did not correlate with markers of HR deficiency but HR deficiency wa...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/16335d8252804f3a9e5594503bbf84fa |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:16335d8252804f3a9e5594503bbf84fa |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:16335d8252804f3a9e5594503bbf84fa2021-12-02T14:49:16ZHomologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer10.1038/s41467-020-16142-72041-1723https://doaj.org/article/16335d8252804f3a9e5594503bbf84fa2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16142-7https://doaj.org/toc/2041-1723Defects in homologous recombination (HR) are found in some triple negative breast cancers, suggesting they may be sensitive to PARP inhibitors. In this phase II clinical trial of the PARP inhibitor rucaparib, changes in Ki67 levels did not correlate with markers of HR deficiency but HR deficiency was detected in 69% of tumours, indicating that PARP inhibitors may be a useful treatment.Neha ChopraHolly ToveyAlex PearsonRos CuttsChristy TomsPaula ProszekMichael HubankMitch DowsettAndrew DodsonFrances DaleyDivya KriplaniHeidi GevenslebenHelen Ruth DaviesAndrea DegasperiRebecca RoylanceStephen ChanAndrew TuttAnthony SkeneAbigail EvansJudith M. BlissSerena Nik-ZainalNicholas C. TurnerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Neha Chopra Holly Tovey Alex Pearson Ros Cutts Christy Toms Paula Proszek Michael Hubank Mitch Dowsett Andrew Dodson Frances Daley Divya Kriplani Heidi Gevensleben Helen Ruth Davies Andrea Degasperi Rebecca Roylance Stephen Chan Andrew Tutt Anthony Skene Abigail Evans Judith M. Bliss Serena Nik-Zainal Nicholas C. Turner Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer |
| description |
Defects in homologous recombination (HR) are found in some triple negative breast cancers, suggesting they may be sensitive to PARP inhibitors. In this phase II clinical trial of the PARP inhibitor rucaparib, changes in Ki67 levels did not correlate with markers of HR deficiency but HR deficiency was detected in 69% of tumours, indicating that PARP inhibitors may be a useful treatment. |
| format |
article |
| author |
Neha Chopra Holly Tovey Alex Pearson Ros Cutts Christy Toms Paula Proszek Michael Hubank Mitch Dowsett Andrew Dodson Frances Daley Divya Kriplani Heidi Gevensleben Helen Ruth Davies Andrea Degasperi Rebecca Roylance Stephen Chan Andrew Tutt Anthony Skene Abigail Evans Judith M. Bliss Serena Nik-Zainal Nicholas C. Turner |
| author_facet |
Neha Chopra Holly Tovey Alex Pearson Ros Cutts Christy Toms Paula Proszek Michael Hubank Mitch Dowsett Andrew Dodson Frances Daley Divya Kriplani Heidi Gevensleben Helen Ruth Davies Andrea Degasperi Rebecca Roylance Stephen Chan Andrew Tutt Anthony Skene Abigail Evans Judith M. Bliss Serena Nik-Zainal Nicholas C. Turner |
| author_sort |
Neha Chopra |
| title |
Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer |
| title_short |
Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer |
| title_full |
Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer |
| title_fullStr |
Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer |
| title_full_unstemmed |
Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer |
| title_sort |
homologous recombination dna repair deficiency and parp inhibition activity in primary triple negative breast cancer |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/16335d8252804f3a9e5594503bbf84fa |
| work_keys_str_mv |
AT nehachopra homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT hollytovey homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT alexpearson homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT roscutts homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT christytoms homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT paulaproszek homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT michaelhubank homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT mitchdowsett homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT andrewdodson homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT francesdaley homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT divyakriplani homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT heidigevensleben homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT helenruthdavies homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT andreadegasperi homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT rebeccaroylance homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT stephenchan homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT andrewtutt homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT anthonyskene homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT abigailevans homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT judithmbliss homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT serenanikzainal homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer AT nicholascturner homologousrecombinationdnarepairdeficiencyandparpinhibitionactivityinprimarytriplenegativebreastcancer |
| _version_ |
1718389493790146560 |