Identification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore

Identification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore

Existing methods used for peptide analysis suffer from low sensitivity and specificity. Here the authors demonstrate the nanopore-based size-discrimination and purity analysis of short homopolymeric peptides with a single amino acid resolution.

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Autores principales: Fabien Piguet, Hadjer Ouldali, Manuela Pastoriza-Gallego, Philippe Manivet, Juan Pelta, Abdelghani Oukhaled
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/1633ddd585644efcac9f78479969cdde
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spelling oai:doaj.org-article:1633ddd585644efcac9f78479969cdde2021-12-02T14:40:44ZIdentification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore10.1038/s41467-018-03418-22041-1723https://doaj.org/article/1633ddd585644efcac9f78479969cdde2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03418-2https://doaj.org/toc/2041-1723Existing methods used for peptide analysis suffer from low sensitivity and specificity. Here the authors demonstrate the nanopore-based size-discrimination and purity analysis of short homopolymeric peptides with a single amino acid resolution.Fabien PiguetHadjer OuldaliManuela Pastoriza-GallegoPhilippe ManivetJuan PeltaAbdelghani OukhaledNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Fabien Piguet
Hadjer Ouldali
Manuela Pastoriza-Gallego
Philippe Manivet
Juan Pelta
Abdelghani Oukhaled
Identification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore
description Existing methods used for peptide analysis suffer from low sensitivity and specificity. Here the authors demonstrate the nanopore-based size-discrimination and purity analysis of short homopolymeric peptides with a single amino acid resolution.
format article
author Fabien Piguet
Hadjer Ouldali
Manuela Pastoriza-Gallego
Philippe Manivet
Juan Pelta
Abdelghani Oukhaled
author_facet Fabien Piguet
Hadjer Ouldali
Manuela Pastoriza-Gallego
Philippe Manivet
Juan Pelta
Abdelghani Oukhaled
author_sort Fabien Piguet
title Identification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore
title_short Identification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore
title_full Identification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore
title_fullStr Identification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore
title_full_unstemmed Identification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore
title_sort identification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/1633ddd585644efcac9f78479969cdde
work_keys_str_mv AT fabienpiguet identificationofsingleaminoaciddifferencesinuniformlychargedhomopolymericpeptideswithaerolysinnanopore
AT hadjerouldali identificationofsingleaminoaciddifferencesinuniformlychargedhomopolymericpeptideswithaerolysinnanopore
AT manuelapastorizagallego identificationofsingleaminoaciddifferencesinuniformlychargedhomopolymericpeptideswithaerolysinnanopore
AT philippemanivet identificationofsingleaminoaciddifferencesinuniformlychargedhomopolymericpeptideswithaerolysinnanopore
AT juanpelta identificationofsingleaminoaciddifferencesinuniformlychargedhomopolymericpeptideswithaerolysinnanopore
AT abdelghanioukhaled identificationofsingleaminoaciddifferencesinuniformlychargedhomopolymericpeptideswithaerolysinnanopore
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