Postoperative deterioration in health related quality of life as predictor for survival in patients with glioblastoma: a prospective study.

<h4>Background</h4>Studies indicate that acquired deficits negatively affect patients' self-reported health related quality of life (HRQOL) and survival, but the impact of HRQOL deterioration after surgery on survival has not been explored.<h4>Objective</h4>Assess if cha...

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Autores principales:	Asgeir S Jakola, Sasha Gulati, Clemens Weber, Geirmund Unsgård, Ole Solheim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/16341fd8940a44789a4c1c14a13879cd
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spelling	oai:doaj.org-article:16341fd8940a44789a4c1c14a13879cd2021-11-18T07:32:38ZPostoperative deterioration in health related quality of life as predictor for survival in patients with glioblastoma: a prospective study.1932-620310.1371/journal.pone.0028592https://doaj.org/article/16341fd8940a44789a4c1c14a13879cd2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22174842/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Studies indicate that acquired deficits negatively affect patients' self-reported health related quality of life (HRQOL) and survival, but the impact of HRQOL deterioration after surgery on survival has not been explored.<h4>Objective</h4>Assess if change in HRQOL after surgery is a predictor for survival in patients with glioblastoma.<h4>Methods</h4>Sixty-one patients with glioblastoma were included. The majority of patients (n = 56, 91.8%) were operated using a neuronavigation system which utilizes 3D preoperative MRI and updated intraoperative 3D ultrasound volumes to guide resection. HRQOL was assessed using EuroQol 5D (EQ-5D), a generic instrument. HRQOL data were collected 1-3 days preoperatively and after 6 weeks. The mean change in EQ-5D index was -0.05 (95% CI -0.15-0.05) 6 weeks after surgery (p = 0.285). There were 30 patients (49.2%) reporting deterioration 6 weeks after surgery. In a Cox multivariate survival analysis we evaluated deterioration in HRQOL after surgery together with established risk factors (age, preoperative condition, radiotherapy, temozolomide and extent of resection).<h4>Results</h4>There were significant independent associations between survival and use of temozolomide (HR 0.30, p = 0.019), radiotherapy (HR 0.26, p = 0.030), and deterioration in HRQOL after surgery (HR 2.02, p = 0.045). Inclusion of surgically acquired deficits in the model did not alter the conclusion.<h4>Conclusion</h4>Early deterioration in HRQOL after surgery is independently and markedly associated with impaired survival in patients with glioblastoma. Deterioration in patient reported HRQOL after surgery is a meaningful outcome in surgical neuro-oncology, as the measure reflects both the burden of symptoms and treatment hazards and is linked to overall survival.Asgeir S JakolaSasha GulatiClemens WeberGeirmund UnsgårdOle SolheimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 12, p e28592 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Asgeir S Jakola Sasha Gulati Clemens Weber Geirmund Unsgård Ole Solheim Postoperative deterioration in health related quality of life as predictor for survival in patients with glioblastoma: a prospective study.
description	<h4>Background</h4>Studies indicate that acquired deficits negatively affect patients' self-reported health related quality of life (HRQOL) and survival, but the impact of HRQOL deterioration after surgery on survival has not been explored.<h4>Objective</h4>Assess if change in HRQOL after surgery is a predictor for survival in patients with glioblastoma.<h4>Methods</h4>Sixty-one patients with glioblastoma were included. The majority of patients (n = 56, 91.8%) were operated using a neuronavigation system which utilizes 3D preoperative MRI and updated intraoperative 3D ultrasound volumes to guide resection. HRQOL was assessed using EuroQol 5D (EQ-5D), a generic instrument. HRQOL data were collected 1-3 days preoperatively and after 6 weeks. The mean change in EQ-5D index was -0.05 (95% CI -0.15-0.05) 6 weeks after surgery (p = 0.285). There were 30 patients (49.2%) reporting deterioration 6 weeks after surgery. In a Cox multivariate survival analysis we evaluated deterioration in HRQOL after surgery together with established risk factors (age, preoperative condition, radiotherapy, temozolomide and extent of resection).<h4>Results</h4>There were significant independent associations between survival and use of temozolomide (HR 0.30, p = 0.019), radiotherapy (HR 0.26, p = 0.030), and deterioration in HRQOL after surgery (HR 2.02, p = 0.045). Inclusion of surgically acquired deficits in the model did not alter the conclusion.<h4>Conclusion</h4>Early deterioration in HRQOL after surgery is independently and markedly associated with impaired survival in patients with glioblastoma. Deterioration in patient reported HRQOL after surgery is a meaningful outcome in surgical neuro-oncology, as the measure reflects both the burden of symptoms and treatment hazards and is linked to overall survival.
format	article
author	Asgeir S Jakola Sasha Gulati Clemens Weber Geirmund Unsgård Ole Solheim
author_facet	Asgeir S Jakola Sasha Gulati Clemens Weber Geirmund Unsgård Ole Solheim
author_sort	Asgeir S Jakola
title	Postoperative deterioration in health related quality of life as predictor for survival in patients with glioblastoma: a prospective study.
title_short	Postoperative deterioration in health related quality of life as predictor for survival in patients with glioblastoma: a prospective study.
title_full	Postoperative deterioration in health related quality of life as predictor for survival in patients with glioblastoma: a prospective study.
title_fullStr	Postoperative deterioration in health related quality of life as predictor for survival in patients with glioblastoma: a prospective study.
title_full_unstemmed	Postoperative deterioration in health related quality of life as predictor for survival in patients with glioblastoma: a prospective study.
title_sort	postoperative deterioration in health related quality of life as predictor for survival in patients with glioblastoma: a prospective study.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/16341fd8940a44789a4c1c14a13879cd
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Postoperative deterioration in health related quality of life as predictor for survival in patients with glioblastoma: a prospective study.

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