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Heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype

Abstract Heart failure (HF) has no cure and, for HF with preserved ejection fraction (HFpEF), no life-extending treatments. Defining the clinical epidemiology of HF could facilitate earlier identification of high-risk individuals. We define the clinical epidemiology of HF subtypes (HFpEF and HF with...

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Autores principales:	Rebecca T. Levinson, Nataraja Sarma Vaitinidin, Eric Farber-Eger, Dan M. Roden, Thomas A. Lasko, Quinn S. Wells, Jonathan D. Mosley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/16365d18d17547e3b97bbedbf892776a
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spelling	oai:doaj.org-article:16365d18d17547e3b97bbedbf892776a2021-12-02T15:15:04ZHeart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype10.1038/s41598-021-97831-12045-2322https://doaj.org/article/16365d18d17547e3b97bbedbf892776a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97831-1https://doaj.org/toc/2045-2322Abstract Heart failure (HF) has no cure and, for HF with preserved ejection fraction (HFpEF), no life-extending treatments. Defining the clinical epidemiology of HF could facilitate earlier identification of high-risk individuals. We define the clinical epidemiology of HF subtypes (HFpEF and HF with reduced ejection fraction [HFrEF]), identified among 2.7 million individuals receiving routine clinical care. Differences in patterns and rates of accumulation of comorbidities, frequency of hospitalization, use of specialty care, were defined for each HF subtype. Among 28,156 HF cases, 8322 (30%) were HFpEF and 11,677 (42%) were HFrEF. HFpEF was the more prevalent subtype among older women. 177 Phenotypes differentially associated with HFpEF versus HFrEF. HFrEF was more frequently associated with diagnoses related to ischemic cardiac injury while HFpEF was associated more with non-cardiac comorbidities and HF symptoms. These comorbidity patterns were frequently present 3 years prior to a HFpEF diagnosis. HF subtypes demonstrated distinct patterns of clinical co-morbidities and disease progression. For HFpEF, these comorbidities were often non-cardiac and manifested prior to the onset of a HF diagnosis. Recognizing these comorbidity patterns, along the care continuum, may present a window of opportunity to identify individuals at risk for developing incident HFpEF.Rebecca T. LevinsonNataraja Sarma VaitinidinEric Farber-EgerDan M. RodenThomas A. LaskoQuinn S. WellsJonathan D. MosleyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rebecca T. Levinson Nataraja Sarma Vaitinidin Eric Farber-Eger Dan M. Roden Thomas A. Lasko Quinn S. Wells Jonathan D. Mosley Heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype
description	Abstract Heart failure (HF) has no cure and, for HF with preserved ejection fraction (HFpEF), no life-extending treatments. Defining the clinical epidemiology of HF could facilitate earlier identification of high-risk individuals. We define the clinical epidemiology of HF subtypes (HFpEF and HF with reduced ejection fraction [HFrEF]), identified among 2.7 million individuals receiving routine clinical care. Differences in patterns and rates of accumulation of comorbidities, frequency of hospitalization, use of specialty care, were defined for each HF subtype. Among 28,156 HF cases, 8322 (30%) were HFpEF and 11,677 (42%) were HFrEF. HFpEF was the more prevalent subtype among older women. 177 Phenotypes differentially associated with HFpEF versus HFrEF. HFrEF was more frequently associated with diagnoses related to ischemic cardiac injury while HFpEF was associated more with non-cardiac comorbidities and HF symptoms. These comorbidity patterns were frequently present 3 years prior to a HFpEF diagnosis. HF subtypes demonstrated distinct patterns of clinical co-morbidities and disease progression. For HFpEF, these comorbidities were often non-cardiac and manifested prior to the onset of a HF diagnosis. Recognizing these comorbidity patterns, along the care continuum, may present a window of opportunity to identify individuals at risk for developing incident HFpEF.
format	article
author	Rebecca T. Levinson Nataraja Sarma Vaitinidin Eric Farber-Eger Dan M. Roden Thomas A. Lasko Quinn S. Wells Jonathan D. Mosley
author_facet	Rebecca T. Levinson Nataraja Sarma Vaitinidin Eric Farber-Eger Dan M. Roden Thomas A. Lasko Quinn S. Wells Jonathan D. Mosley
author_sort	Rebecca T. Levinson
title	Heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype
title_short	Heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype
title_full	Heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype
title_fullStr	Heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype
title_full_unstemmed	Heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype
title_sort	heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/16365d18d17547e3b97bbedbf892776a
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Heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype

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