Regional Cerebral Blood Flow Abnormalities in Neurosyphilis: A Pilot SPECT Study

Objective: Clinical and radiological findings on neurosyphilis are fairly non-specific and there is a paucity of functional neuroimaging studies on neurosyphilis other than case reports and case series. The purpose of this study was to investigate brain perfusion abnormalities in patients with neuro...

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Autores principales:	Jooyeon J. Im, Hyeonseok Jeong, Young Do Kim, Kyung-Sool Jang, In-Uk Song, Yong-An Chung
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	neurosyphilis single-photon emission computed tomography regional cerebral blood flow cognitive function neuroimaging Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1636dcd0b13b44708057ed92a2fea684
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spelling	oai:doaj.org-article:1636dcd0b13b44708057ed92a2fea6842021-11-10T07:59:08ZRegional Cerebral Blood Flow Abnormalities in Neurosyphilis: A Pilot SPECT Study1664-229510.3389/fneur.2021.726006https://doaj.org/article/1636dcd0b13b44708057ed92a2fea6842021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.726006/fullhttps://doaj.org/toc/1664-2295Objective: Clinical and radiological findings on neurosyphilis are fairly non-specific and there is a paucity of functional neuroimaging studies on neurosyphilis other than case reports and case series. The purpose of this study was to investigate brain perfusion abnormalities in patients with neurosyphilis.Methods: Four HIV-negative neurosyphilis patients and 4 healthy controls underwent clinical evaluation, brain technetium-99m ethyl cysteinate dimer (99mTc-ECD) single-photon emission computed tomography (SPECT) imaging, and neuropsychological assessments which included the Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), Clinical Dementia Rating—Sum of Boxes (CDR-SOB), and Global Deterioration Scale (GDS). Voxel-wise differences in regional cerebral blood flow were compared between the two groups.Results: Neuropsychological test results indicated cognitive impairment in all patients. SPECT analysis revealed multifocal hypoperfusion predominantly in the frontal, insular, and posterior cingulate regions in neurosyphilis patients compared with healthy controls (family-wise error corrected p < 0.05).Conclusions: Together with previous findings, our results suggest that the hypoperfusion in the frontal, insular, and posterior cingulate regions may reflect cognitive impairments observed in neurosyphilis patients. Further studies with larger samples are needed to confirm our findings.Jooyeon J. ImHyeonseok JeongHyeonseok JeongYoung Do KimKyung-Sool JangIn-Uk SongYong-An ChungYong-An ChungFrontiers Media S.A.articleneurosyphilissingle-photon emission computed tomographyregional cerebral blood flowcognitive functionneuroimagingNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurosyphilis single-photon emission computed tomography regional cerebral blood flow cognitive function neuroimaging Neurology. Diseases of the nervous system RC346-429
spellingShingle	neurosyphilis single-photon emission computed tomography regional cerebral blood flow cognitive function neuroimaging Neurology. Diseases of the nervous system RC346-429 Jooyeon J. Im Hyeonseok Jeong Hyeonseok Jeong Young Do Kim Kyung-Sool Jang In-Uk Song Yong-An Chung Yong-An Chung Regional Cerebral Blood Flow Abnormalities in Neurosyphilis: A Pilot SPECT Study
description	Objective: Clinical and radiological findings on neurosyphilis are fairly non-specific and there is a paucity of functional neuroimaging studies on neurosyphilis other than case reports and case series. The purpose of this study was to investigate brain perfusion abnormalities in patients with neurosyphilis.Methods: Four HIV-negative neurosyphilis patients and 4 healthy controls underwent clinical evaluation, brain technetium-99m ethyl cysteinate dimer (99mTc-ECD) single-photon emission computed tomography (SPECT) imaging, and neuropsychological assessments which included the Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), Clinical Dementia Rating—Sum of Boxes (CDR-SOB), and Global Deterioration Scale (GDS). Voxel-wise differences in regional cerebral blood flow were compared between the two groups.Results: Neuropsychological test results indicated cognitive impairment in all patients. SPECT analysis revealed multifocal hypoperfusion predominantly in the frontal, insular, and posterior cingulate regions in neurosyphilis patients compared with healthy controls (family-wise error corrected p < 0.05).Conclusions: Together with previous findings, our results suggest that the hypoperfusion in the frontal, insular, and posterior cingulate regions may reflect cognitive impairments observed in neurosyphilis patients. Further studies with larger samples are needed to confirm our findings.
format	article
author	Jooyeon J. Im Hyeonseok Jeong Hyeonseok Jeong Young Do Kim Kyung-Sool Jang In-Uk Song Yong-An Chung Yong-An Chung
author_facet	Jooyeon J. Im Hyeonseok Jeong Hyeonseok Jeong Young Do Kim Kyung-Sool Jang In-Uk Song Yong-An Chung Yong-An Chung
author_sort	Jooyeon J. Im
title	Regional Cerebral Blood Flow Abnormalities in Neurosyphilis: A Pilot SPECT Study
title_short	Regional Cerebral Blood Flow Abnormalities in Neurosyphilis: A Pilot SPECT Study
title_full	Regional Cerebral Blood Flow Abnormalities in Neurosyphilis: A Pilot SPECT Study
title_fullStr	Regional Cerebral Blood Flow Abnormalities in Neurosyphilis: A Pilot SPECT Study
title_full_unstemmed	Regional Cerebral Blood Flow Abnormalities in Neurosyphilis: A Pilot SPECT Study
title_sort	regional cerebral blood flow abnormalities in neurosyphilis: a pilot spect study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1636dcd0b13b44708057ed92a2fea684
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Regional Cerebral Blood Flow Abnormalities in Neurosyphilis: A Pilot SPECT Study

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