Egg and saturated fat containing breakfasts have no acute effect on acute glycemic control in healthy adults: a randomized partial crossover trial

Abstract Background/Objectives High egg consumption is associated with poor glycemic control. Considering the widespread consumption of eggs, it is crucial to determine causality in this association. We tested if egg consumption acutely alters glucose disposal in the absence or presence of saturated...

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Autores principales:	Chathurika S. Dhanasekara, John A. Dawson, Martin Binks, Allison Childress, Nikhil V. Dhurandhar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/16376ea32679489980b8fd9dcd78be30
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spelling	oai:doaj.org-article:16376ea32679489980b8fd9dcd78be302021-11-14T12:25:00ZEgg and saturated fat containing breakfasts have no acute effect on acute glycemic control in healthy adults: a randomized partial crossover trial10.1038/s41387-021-00176-x2044-4052https://doaj.org/article/16376ea32679489980b8fd9dcd78be302021-11-01T00:00:00Zhttps://doi.org/10.1038/s41387-021-00176-xhttps://doaj.org/toc/2044-4052Abstract Background/Objectives High egg consumption is associated with poor glycemic control. Considering the widespread consumption of eggs, it is crucial to determine causality in this association. We tested if egg consumption acutely alters glucose disposal in the absence or presence of saturated fat, which is frequently consumed with eggs. Subjects/Methods In a randomized partial crossover clinical trial, 48 subjects (consuming ≥ 1 egg/week) received two of four isocaloric, macronutrient-matched breakfasts. The groups were defined based on the main ingredient of the breakfasts offered: eggs (EB); saturated fat (SB); eggs and saturated fat (ES); and control, which included a cereal based breakfast (CB). The breakfasts were offered in two testing sessions spaced seven days apart. Six blood samples (pre breakfast (fasting); 30, 60, 90, 120, and 180 minutes post breakfast) were collected to measure glucose and insulin levels. Area under the curves (AUC) were analyzed controlling for the baseline concentrations using mixed-effects models accounting for within-subject dependencies to compare these across breakfast assignments. Results Forty-eight patients (46% males, age 25.8 ± 7.7 years, BMI 25.7 ± 4.6 kg/m2) were included. Neither EB, SB nor ES was associated with a significant difference in AUC of glucose or insulin compared to CB (p > 0.1). Conclusions Acutely, consumption of egg breakfast with or without accompanying saturated fat does not adversely affect glucose disposal in healthy adults. While this is reassuring for continued egg consumption, a long-term evaluation of egg intake with or without saturated fat would be the next step.Chathurika S. DhanasekaraJohn A. DawsonMartin BinksAllison ChildressNikhil V. DhurandharNature Publishing GrouparticleNutritional diseases. Deficiency diseasesRC620-627ENNutrition & Diabetes, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Nutritional diseases. Deficiency diseases RC620-627 Chathurika S. Dhanasekara John A. Dawson Martin Binks Allison Childress Nikhil V. Dhurandhar Egg and saturated fat containing breakfasts have no acute effect on acute glycemic control in healthy adults: a randomized partial crossover trial
description	Abstract Background/Objectives High egg consumption is associated with poor glycemic control. Considering the widespread consumption of eggs, it is crucial to determine causality in this association. We tested if egg consumption acutely alters glucose disposal in the absence or presence of saturated fat, which is frequently consumed with eggs. Subjects/Methods In a randomized partial crossover clinical trial, 48 subjects (consuming ≥ 1 egg/week) received two of four isocaloric, macronutrient-matched breakfasts. The groups were defined based on the main ingredient of the breakfasts offered: eggs (EB); saturated fat (SB); eggs and saturated fat (ES); and control, which included a cereal based breakfast (CB). The breakfasts were offered in two testing sessions spaced seven days apart. Six blood samples (pre breakfast (fasting); 30, 60, 90, 120, and 180 minutes post breakfast) were collected to measure glucose and insulin levels. Area under the curves (AUC) were analyzed controlling for the baseline concentrations using mixed-effects models accounting for within-subject dependencies to compare these across breakfast assignments. Results Forty-eight patients (46% males, age 25.8 ± 7.7 years, BMI 25.7 ± 4.6 kg/m2) were included. Neither EB, SB nor ES was associated with a significant difference in AUC of glucose or insulin compared to CB (p > 0.1). Conclusions Acutely, consumption of egg breakfast with or without accompanying saturated fat does not adversely affect glucose disposal in healthy adults. While this is reassuring for continued egg consumption, a long-term evaluation of egg intake with or without saturated fat would be the next step.
format	article
author	Chathurika S. Dhanasekara John A. Dawson Martin Binks Allison Childress Nikhil V. Dhurandhar
author_facet	Chathurika S. Dhanasekara John A. Dawson Martin Binks Allison Childress Nikhil V. Dhurandhar
author_sort	Chathurika S. Dhanasekara
title	Egg and saturated fat containing breakfasts have no acute effect on acute glycemic control in healthy adults: a randomized partial crossover trial
title_short	Egg and saturated fat containing breakfasts have no acute effect on acute glycemic control in healthy adults: a randomized partial crossover trial
title_full	Egg and saturated fat containing breakfasts have no acute effect on acute glycemic control in healthy adults: a randomized partial crossover trial
title_fullStr	Egg and saturated fat containing breakfasts have no acute effect on acute glycemic control in healthy adults: a randomized partial crossover trial
title_full_unstemmed	Egg and saturated fat containing breakfasts have no acute effect on acute glycemic control in healthy adults: a randomized partial crossover trial
title_sort	egg and saturated fat containing breakfasts have no acute effect on acute glycemic control in healthy adults: a randomized partial crossover trial
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/16376ea32679489980b8fd9dcd78be30
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Egg and saturated fat containing breakfasts have no acute effect on acute glycemic control in healthy adults: a randomized partial crossover trial

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