A retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis

Abstract Based on the antibody typing classification, Helicobacter pylori infection can be divided into type I H. pylori infection and type II H. pylori infection. To observe the effects of different H. pylori infection types on the distribution of histopathological characteristics and the levels of...

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Autores principales:	Weidong Liu, Junjie Tian, Wenjia Hui, Wenjie Kong, Yan Feng, Junqiang Si, Feng Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/16384e04416b455baae9090766b48cc2
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spelling	oai:doaj.org-article:16384e04416b455baae9090766b48cc22021-12-02T14:21:43ZA retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis10.1038/s41598-021-83647-62045-2322https://doaj.org/article/16384e04416b455baae9090766b48cc22021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83647-6https://doaj.org/toc/2045-2322Abstract Based on the antibody typing classification, Helicobacter pylori infection can be divided into type I H. pylori infection and type II H. pylori infection. To observe the effects of different H. pylori infection types on the distribution of histopathological characteristics and the levels of three items of serum gastric function (PG I, PG II, G-17). 1175 cases from October 2018 to February 2020 were collected with ratio 1:2. All patients were performed with 14C-Urea breath test (14C-UBT), H. pylori antibody typing classification, three items of serum gastric function detection, painless gastroscopy, pathological examination, etc. According to H. pylori antibody typing classification, patients were divided into three groups: type I H. pylori infection group, type II H. pylori infection group and control group. Significant difference existed among type I H. pylori infection group, type II H. pylori infection group and control group in inflammation and activity (χ 2 = 165.43, 354.88, P all < 0.01). The proportion of three groups in OLGA staging had statistic difference (χ 2 = 67.99, P all < 0.01); Compared with type II H. pylori infection group and control group, the level of pepsinogen I, pepsinogen II, gastrin17 in type I H. pylori infection group increased, and PG I/PG II ratio (PG I/PG II ratio, PGR) decreased, which was statistically significant (χ 2 = 35.08, 166.24, 134.21, 141.19; P all < 0.01). Type I H. pylori infection worsened the severity of gastric mucosal inflammation and activity. H. pylori infection was prone to induce atrophy of gastric mucosa, while type I H. pylori infection played a key role in promoting the progress of atrophic gastritis and affected the level of serum gastric function. The study indicated that the eradication of H. pylori should be treated individually.Weidong LiuJunjie TianWenjia HuiWenjie KongYan FengJunqiang SiFeng GaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Weidong Liu Junjie Tian Wenjia Hui Wenjie Kong Yan Feng Junqiang Si Feng Gao A retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis
description	Abstract Based on the antibody typing classification, Helicobacter pylori infection can be divided into type I H. pylori infection and type II H. pylori infection. To observe the effects of different H. pylori infection types on the distribution of histopathological characteristics and the levels of three items of serum gastric function (PG I, PG II, G-17). 1175 cases from October 2018 to February 2020 were collected with ratio 1:2. All patients were performed with 14C-Urea breath test (14C-UBT), H. pylori antibody typing classification, three items of serum gastric function detection, painless gastroscopy, pathological examination, etc. According to H. pylori antibody typing classification, patients were divided into three groups: type I H. pylori infection group, type II H. pylori infection group and control group. Significant difference existed among type I H. pylori infection group, type II H. pylori infection group and control group in inflammation and activity (χ 2 = 165.43, 354.88, P all < 0.01). The proportion of three groups in OLGA staging had statistic difference (χ 2 = 67.99, P all < 0.01); Compared with type II H. pylori infection group and control group, the level of pepsinogen I, pepsinogen II, gastrin17 in type I H. pylori infection group increased, and PG I/PG II ratio (PG I/PG II ratio, PGR) decreased, which was statistically significant (χ 2 = 35.08, 166.24, 134.21, 141.19; P all < 0.01). Type I H. pylori infection worsened the severity of gastric mucosal inflammation and activity. H. pylori infection was prone to induce atrophy of gastric mucosa, while type I H. pylori infection played a key role in promoting the progress of atrophic gastritis and affected the level of serum gastric function. The study indicated that the eradication of H. pylori should be treated individually.
format	article
author	Weidong Liu Junjie Tian Wenjia Hui Wenjie Kong Yan Feng Junqiang Si Feng Gao
author_facet	Weidong Liu Junjie Tian Wenjia Hui Wenjie Kong Yan Feng Junqiang Si Feng Gao
author_sort	Weidong Liu
title	A retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis
title_short	A retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis
title_full	A retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis
title_fullStr	A retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis
title_full_unstemmed	A retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis
title_sort	retrospective study assessing the acceleration effect of type i helicobacter pylori infection on the progress of atrophic gastritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/16384e04416b455baae9090766b48cc2
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A retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis

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