Incremental changes in QRS duration as predictor for cardiovascular disease: a 21-year follow-up of a randomly selected general population

Abstract The QRS complex has been shown to be a prognostic marker in coronary artery disease. However, the changes in QRS duration over time, and its predictive value for cardiovascular disease in the general population is poorly studied. So we aimed to explore if increased QRS duration from the age...

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Autores principales:	Xiaojing Chen, Per-Olof Hansson, Erik Thunström, Zacharias Mandalenakis, Kenneth Caidahl, Michael Fu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1639cb5e9a854f3b827d0f4e1e65ddec
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spelling	oai:doaj.org-article:1639cb5e9a854f3b827d0f4e1e65ddec2021-12-02T16:10:37ZIncremental changes in QRS duration as predictor for cardiovascular disease: a 21-year follow-up of a randomly selected general population10.1038/s41598-021-93024-y2045-2322https://doaj.org/article/1639cb5e9a854f3b827d0f4e1e65ddec2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93024-yhttps://doaj.org/toc/2045-2322Abstract The QRS complex has been shown to be a prognostic marker in coronary artery disease. However, the changes in QRS duration over time, and its predictive value for cardiovascular disease in the general population is poorly studied. So we aimed to explore if increased QRS duration from the age of 50–60 is associated with increased risk of major cardiovascular events during a further follow-up to age 71. A random population sample of 798 men born in 1943 were examined in 1993 at 50 years of age, and re-examined in 2003 at age 60 and 2014 at age 71. Participants who developed cardiovascular disease before the re-examination in 2003 (n = 86) or missing value of QRS duration in 2003 (n = 127) were excluded. ΔQRS was defined as increase in QRS duration from age 50 to 60. Participants were divided into three groups: group 1: ΔQRS < 4 ms, group 2: 4 ms ≤ ΔQRS < 8 ms, group 3: ΔQRS ≥ 8 ms. Endpoints were major cardiovascular events. And we found compared with men in group 1 (ΔQRS < 4 ms), men with ΔQRS ≥ 8 ms had a 56% increased risk of MACE during follow-up to 71 years of age after adjusted for BMI, systolic blood pressure, smoking, hyperlipidemia, diabetes and heart rate in a multivariable Cox regression analysis (HR 1.56, 95% CI:1.07–2.27, P = 0.022). In conclusion, in this longitudinal follow-up over a decade QRS duration increased in almost two out of three men between age 50 and 60 and the increased QRS duration in middle age is an independent predictor of major cardiovascular events.Xiaojing ChenPer-Olof HanssonErik ThunströmZacharias MandalenakisKenneth CaidahlMichael FuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaojing Chen Per-Olof Hansson Erik Thunström Zacharias Mandalenakis Kenneth Caidahl Michael Fu Incremental changes in QRS duration as predictor for cardiovascular disease: a 21-year follow-up of a randomly selected general population
description	Abstract The QRS complex has been shown to be a prognostic marker in coronary artery disease. However, the changes in QRS duration over time, and its predictive value for cardiovascular disease in the general population is poorly studied. So we aimed to explore if increased QRS duration from the age of 50–60 is associated with increased risk of major cardiovascular events during a further follow-up to age 71. A random population sample of 798 men born in 1943 were examined in 1993 at 50 years of age, and re-examined in 2003 at age 60 and 2014 at age 71. Participants who developed cardiovascular disease before the re-examination in 2003 (n = 86) or missing value of QRS duration in 2003 (n = 127) were excluded. ΔQRS was defined as increase in QRS duration from age 50 to 60. Participants were divided into three groups: group 1: ΔQRS < 4 ms, group 2: 4 ms ≤ ΔQRS < 8 ms, group 3: ΔQRS ≥ 8 ms. Endpoints were major cardiovascular events. And we found compared with men in group 1 (ΔQRS < 4 ms), men with ΔQRS ≥ 8 ms had a 56% increased risk of MACE during follow-up to 71 years of age after adjusted for BMI, systolic blood pressure, smoking, hyperlipidemia, diabetes and heart rate in a multivariable Cox regression analysis (HR 1.56, 95% CI:1.07–2.27, P = 0.022). In conclusion, in this longitudinal follow-up over a decade QRS duration increased in almost two out of three men between age 50 and 60 and the increased QRS duration in middle age is an independent predictor of major cardiovascular events.
format	article
author	Xiaojing Chen Per-Olof Hansson Erik Thunström Zacharias Mandalenakis Kenneth Caidahl Michael Fu
author_facet	Xiaojing Chen Per-Olof Hansson Erik Thunström Zacharias Mandalenakis Kenneth Caidahl Michael Fu
author_sort	Xiaojing Chen
title	Incremental changes in QRS duration as predictor for cardiovascular disease: a 21-year follow-up of a randomly selected general population
title_short	Incremental changes in QRS duration as predictor for cardiovascular disease: a 21-year follow-up of a randomly selected general population
title_full	Incremental changes in QRS duration as predictor for cardiovascular disease: a 21-year follow-up of a randomly selected general population
title_fullStr	Incremental changes in QRS duration as predictor for cardiovascular disease: a 21-year follow-up of a randomly selected general population
title_full_unstemmed	Incremental changes in QRS duration as predictor for cardiovascular disease: a 21-year follow-up of a randomly selected general population
title_sort	incremental changes in qrs duration as predictor for cardiovascular disease: a 21-year follow-up of a randomly selected general population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1639cb5e9a854f3b827d0f4e1e65ddec
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Incremental changes in QRS duration as predictor for cardiovascular disease: a 21-year follow-up of a randomly selected general population

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