Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance

Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance

The relationship between autophagy and BRAF signalling is unclear. Here, the authors describe that BRAF inhibition induces the autophagy-lysosomal function in BRAF-mutant melanomas via modulation of the TFEB and ZKSCAN3 transcriptome, which downregulates TGF-β and suppresses melanoma progression.

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Autores principales: Shun Li, Ying Song, Christine Quach, Hongrui Guo, Gyu-Beom Jang, Hadi Maazi, Shihui Zhao, Nathaniel A. Sands, Qingsong Liu, Gino K. In, David Peng, Weiming Yuan, Keigo Machida, Min Yu, Omid Akbari, Ashley Hagiya, Yongfei Yang, Vasu Punj, Liling Tang, Chengyu Liang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/16402280b75e478390036fae4511579a
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spelling oai:doaj.org-article:16402280b75e478390036fae4511579a2021-12-02T16:58:13ZTranscriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance10.1038/s41467-019-09634-82041-1723https://doaj.org/article/16402280b75e478390036fae4511579a2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09634-8https://doaj.org/toc/2041-1723The relationship between autophagy and BRAF signalling is unclear. Here, the authors describe that BRAF inhibition induces the autophagy-lysosomal function in BRAF-mutant melanomas via modulation of the TFEB and ZKSCAN3 transcriptome, which downregulates TGF-β and suppresses melanoma progression.Shun LiYing SongChristine QuachHongrui GuoGyu-Beom JangHadi MaaziShihui ZhaoNathaniel A. SandsQingsong LiuGino K. InDavid PengWeiming YuanKeigo MachidaMin YuOmid AkbariAshley HagiyaYongfei YangVasu PunjLiling TangChengyu LiangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shun Li
Ying Song
Christine Quach
Hongrui Guo
Gyu-Beom Jang
Hadi Maazi
Shihui Zhao
Nathaniel A. Sands
Qingsong Liu
Gino K. In
David Peng
Weiming Yuan
Keigo Machida
Min Yu
Omid Akbari
Ashley Hagiya
Yongfei Yang
Vasu Punj
Liling Tang
Chengyu Liang
Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance
description The relationship between autophagy and BRAF signalling is unclear. Here, the authors describe that BRAF inhibition induces the autophagy-lysosomal function in BRAF-mutant melanomas via modulation of the TFEB and ZKSCAN3 transcriptome, which downregulates TGF-β and suppresses melanoma progression.
format article
author Shun Li
Ying Song
Christine Quach
Hongrui Guo
Gyu-Beom Jang
Hadi Maazi
Shihui Zhao
Nathaniel A. Sands
Qingsong Liu
Gino K. In
David Peng
Weiming Yuan
Keigo Machida
Min Yu
Omid Akbari
Ashley Hagiya
Yongfei Yang
Vasu Punj
Liling Tang
Chengyu Liang
author_facet Shun Li
Ying Song
Christine Quach
Hongrui Guo
Gyu-Beom Jang
Hadi Maazi
Shihui Zhao
Nathaniel A. Sands
Qingsong Liu
Gino K. In
David Peng
Weiming Yuan
Keigo Machida
Min Yu
Omid Akbari
Ashley Hagiya
Yongfei Yang
Vasu Punj
Liling Tang
Chengyu Liang
author_sort Shun Li
title Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance
title_short Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance
title_full Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance
title_fullStr Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance
title_full_unstemmed Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance
title_sort transcriptional regulation of autophagy-lysosomal function in braf-driven melanoma progression and chemoresistance
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/16402280b75e478390036fae4511579a
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