Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders

The multifunctional role of the human skin is well known. It acts as a sensory and immune organ that protects the human body from harmful environmental impacts such as chemical, mechanical, and physical threats, reduces UV radiation effects, prevents moisture loss, and helps thermoregulation. In thi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Stefan R. Stefanov, Velichka Y. Andonova
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	skin diseases lipid-based nanosystems solid lipid nanoparticles nanostructured lipid carriers cream ointment Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/1641fade9cb74d958bc7cdcd1c50ae23
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1641fade9cb74d958bc7cdcd1c50ae23
record_format	dspace
spelling	oai:doaj.org-article:1641fade9cb74d958bc7cdcd1c50ae232021-11-25T18:39:12ZLipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders10.3390/ph141110831424-8247https://doaj.org/article/1641fade9cb74d958bc7cdcd1c50ae232021-10-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1083https://doaj.org/toc/1424-8247The multifunctional role of the human skin is well known. It acts as a sensory and immune organ that protects the human body from harmful environmental impacts such as chemical, mechanical, and physical threats, reduces UV radiation effects, prevents moisture loss, and helps thermoregulation. In this regard, skin disorders related to skin integrity require adequate treatment. Lipid nanoparticles (LN) are recognized as promising drug delivery systems (DDS) in treating skin disorders. Solid lipid nanoparticles (SLN) together with nanostructured lipid carriers (NLC) exhibit excellent tolerability as these are produced from physiological and biodegradable lipids. Moreover, LN applied to the skin can improve stability, drug targeting, occlusion, penetration enhancement, and increased skin hydration compared with other drug nanocarriers. Furthermore, the features of LN can be enhanced by inclusion in suitable bases such as creams, ointments, gels (i.e., hydrogel, emulgel, bigel), lotions, etc. This review focuses on recent developments in lipid nanoparticle systems and their application to treating skin diseases. We point out and consider the reasons for their creation, pay attention to their advantages and disadvantages, list the main production techniques for obtaining them, and examine the place assigned to them in solving the problems caused by skin disorders.Stefan R. StefanovVelichka Y. AndonovaMDPI AGarticleskin diseaseslipid-based nanosystemssolid lipid nanoparticlesnanostructured lipid carrierscreamointmentMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1083, p 1083 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	skin diseases lipid-based nanosystems solid lipid nanoparticles nanostructured lipid carriers cream ointment Medicine R Pharmacy and materia medica RS1-441
spellingShingle	skin diseases lipid-based nanosystems solid lipid nanoparticles nanostructured lipid carriers cream ointment Medicine R Pharmacy and materia medica RS1-441 Stefan R. Stefanov Velichka Y. Andonova Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders
description	The multifunctional role of the human skin is well known. It acts as a sensory and immune organ that protects the human body from harmful environmental impacts such as chemical, mechanical, and physical threats, reduces UV radiation effects, prevents moisture loss, and helps thermoregulation. In this regard, skin disorders related to skin integrity require adequate treatment. Lipid nanoparticles (LN) are recognized as promising drug delivery systems (DDS) in treating skin disorders. Solid lipid nanoparticles (SLN) together with nanostructured lipid carriers (NLC) exhibit excellent tolerability as these are produced from physiological and biodegradable lipids. Moreover, LN applied to the skin can improve stability, drug targeting, occlusion, penetration enhancement, and increased skin hydration compared with other drug nanocarriers. Furthermore, the features of LN can be enhanced by inclusion in suitable bases such as creams, ointments, gels (i.e., hydrogel, emulgel, bigel), lotions, etc. This review focuses on recent developments in lipid nanoparticle systems and their application to treating skin diseases. We point out and consider the reasons for their creation, pay attention to their advantages and disadvantages, list the main production techniques for obtaining them, and examine the place assigned to them in solving the problems caused by skin disorders.
format	article
author	Stefan R. Stefanov Velichka Y. Andonova
author_facet	Stefan R. Stefanov Velichka Y. Andonova
author_sort	Stefan R. Stefanov
title	Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders
title_short	Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders
title_full	Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders
title_fullStr	Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders
title_full_unstemmed	Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders
title_sort	lipid nanoparticulate drug delivery systems: recent advances in the treatment of skin disorders
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1641fade9cb74d958bc7cdcd1c50ae23
work_keys_str_mv	AT stefanrstefanov lipidnanoparticulatedrugdeliverysystemsrecentadvancesinthetreatmentofskindisorders AT velichkayandonova lipidnanoparticulatedrugdeliverysystemsrecentadvancesinthetreatmentofskindisorders
_version_	1718410817342275584

Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders

Ejemplares similares