Leptin Receptor Overlapping Transcript (LEPROT) Is Associated with the Tumor Microenvironment and a Prognostic Predictor in Pan-Cancer

Background:Leptin receptor overlapping transcript (LEPROT) is reported to be involved in metabolism regulation and energy balance as well as molecular signaling of breast cancer and osteosarcoma. LEPROT is expressed in various tissue and is suggested to be involved in cancer developments but with co...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bingsheng Li, Yao He, Pan Li, Xiang Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	leptin receptor overlapping transcript tumor microenvionment tumor immune cell infiltration inflammation pathways immunotherapy bioinformactics Genetics QH426-470
Acceso en línea:	https://doaj.org/article/1645d8778abf4e5f8ebb8bf724e23f67
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1645d8778abf4e5f8ebb8bf724e23f67
record_format	dspace
spelling	oai:doaj.org-article:1645d8778abf4e5f8ebb8bf724e23f672021-11-11T10:26:21ZLeptin Receptor Overlapping Transcript (LEPROT) Is Associated with the Tumor Microenvironment and a Prognostic Predictor in Pan-Cancer1664-802110.3389/fgene.2021.749435https://doaj.org/article/1645d8778abf4e5f8ebb8bf724e23f672021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.749435/fullhttps://doaj.org/toc/1664-8021Background:Leptin receptor overlapping transcript (LEPROT) is reported to be involved in metabolism regulation and energy balance as well as molecular signaling of breast cancer and osteosarcoma. LEPROT is expressed in various tissue and is suggested to be involved in cancer developments but with contradictory roles. The comprehensive knowledge of the effects of LEPROT on cancer development and progression across pan-cancer is still missing.Methods:The expressions of LEPROT in cancers were compared with corresponding normal tissues across pan-cancer types. The relationships between expression and methylation of LEPROT were then demonstrated. The correlations of LEPROT with the tumor microenvironment (TME), including immune checkpoints, tumor immune cells infiltration (TII), and cancer-associated fibroblasts (CAFs), were also investigated. Co-expression analyses and functional enrichments were conducted to suggest the most relevant genes and the mechanisms of the effects in cancers for LEPROT. Finally, the correlations of LEPROT with patient survival and immunotherapy response were explored.Results:LEPROT expression was found to be significantly aberrant in 15/19 (78.9%) cancers compared with corresponding normal tissues; LEPROT was downregulated in 12 cancers and upregulated in three cancers. LEPROT expressions were overall negatively correlated with its methylation alterations. Moreover, LEPROT was profoundly correlated with the TME, including immune checkpoints, TIIs, and CAFs. According to co-expression analyses and functional enrichments, the interactions of LEPROT with the TME may be mediated by the interleukin six signal transducer/the Janus kinase/signal transducers and activators of the transcription signaling pathway. Prognostic values may exist for LEPROT to predict patient survival and immunotherapy response in a context-dependent way.Conclusions:LEPROT affects cancer development by interfering with the TME and regulating inflammatory or immune signals. LEPROT may also serve as a potential prognostic marker or a target in cancer therapy. This is the first study to investigate the roles of LEPROT across pan-cancer.Bingsheng LiBingsheng LiYao HePan LiXiang ChenFrontiers Media S.A.articleleptin receptor overlapping transcripttumor microenvionmenttumor immune cell infiltrationinflammation pathwaysimmunotherapybioinformacticsGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	leptin receptor overlapping transcript tumor microenvionment tumor immune cell infiltration inflammation pathways immunotherapy bioinformactics Genetics QH426-470
spellingShingle	leptin receptor overlapping transcript tumor microenvionment tumor immune cell infiltration inflammation pathways immunotherapy bioinformactics Genetics QH426-470 Bingsheng Li Bingsheng Li Yao He Pan Li Xiang Chen Leptin Receptor Overlapping Transcript (LEPROT) Is Associated with the Tumor Microenvironment and a Prognostic Predictor in Pan-Cancer
description	Background:Leptin receptor overlapping transcript (LEPROT) is reported to be involved in metabolism regulation and energy balance as well as molecular signaling of breast cancer and osteosarcoma. LEPROT is expressed in various tissue and is suggested to be involved in cancer developments but with contradictory roles. The comprehensive knowledge of the effects of LEPROT on cancer development and progression across pan-cancer is still missing.Methods:The expressions of LEPROT in cancers were compared with corresponding normal tissues across pan-cancer types. The relationships between expression and methylation of LEPROT were then demonstrated. The correlations of LEPROT with the tumor microenvironment (TME), including immune checkpoints, tumor immune cells infiltration (TII), and cancer-associated fibroblasts (CAFs), were also investigated. Co-expression analyses and functional enrichments were conducted to suggest the most relevant genes and the mechanisms of the effects in cancers for LEPROT. Finally, the correlations of LEPROT with patient survival and immunotherapy response were explored.Results:LEPROT expression was found to be significantly aberrant in 15/19 (78.9%) cancers compared with corresponding normal tissues; LEPROT was downregulated in 12 cancers and upregulated in three cancers. LEPROT expressions were overall negatively correlated with its methylation alterations. Moreover, LEPROT was profoundly correlated with the TME, including immune checkpoints, TIIs, and CAFs. According to co-expression analyses and functional enrichments, the interactions of LEPROT with the TME may be mediated by the interleukin six signal transducer/the Janus kinase/signal transducers and activators of the transcription signaling pathway. Prognostic values may exist for LEPROT to predict patient survival and immunotherapy response in a context-dependent way.Conclusions:LEPROT affects cancer development by interfering with the TME and regulating inflammatory or immune signals. LEPROT may also serve as a potential prognostic marker or a target in cancer therapy. This is the first study to investigate the roles of LEPROT across pan-cancer.
format	article
author	Bingsheng Li Bingsheng Li Yao He Pan Li Xiang Chen
author_facet	Bingsheng Li Bingsheng Li Yao He Pan Li Xiang Chen
author_sort	Bingsheng Li
title	Leptin Receptor Overlapping Transcript (LEPROT) Is Associated with the Tumor Microenvironment and a Prognostic Predictor in Pan-Cancer
title_short	Leptin Receptor Overlapping Transcript (LEPROT) Is Associated with the Tumor Microenvironment and a Prognostic Predictor in Pan-Cancer
title_full	Leptin Receptor Overlapping Transcript (LEPROT) Is Associated with the Tumor Microenvironment and a Prognostic Predictor in Pan-Cancer
title_fullStr	Leptin Receptor Overlapping Transcript (LEPROT) Is Associated with the Tumor Microenvironment and a Prognostic Predictor in Pan-Cancer
title_full_unstemmed	Leptin Receptor Overlapping Transcript (LEPROT) Is Associated with the Tumor Microenvironment and a Prognostic Predictor in Pan-Cancer
title_sort	leptin receptor overlapping transcript (leprot) is associated with the tumor microenvironment and a prognostic predictor in pan-cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1645d8778abf4e5f8ebb8bf724e23f67
work_keys_str_mv	AT bingshengli leptinreceptoroverlappingtranscriptleprotisassociatedwiththetumormicroenvironmentandaprognosticpredictorinpancancer AT bingshengli leptinreceptoroverlappingtranscriptleprotisassociatedwiththetumormicroenvironmentandaprognosticpredictorinpancancer AT yaohe leptinreceptoroverlappingtranscriptleprotisassociatedwiththetumormicroenvironmentandaprognosticpredictorinpancancer AT panli leptinreceptoroverlappingtranscriptleprotisassociatedwiththetumormicroenvironmentandaprognosticpredictorinpancancer AT xiangchen leptinreceptoroverlappingtranscriptleprotisassociatedwiththetumormicroenvironmentandaprognosticpredictorinpancancer
_version_	1718439104787513344

Leptin Receptor Overlapping Transcript (LEPROT) Is Associated with the Tumor Microenvironment and a Prognostic Predictor in Pan-Cancer

Ejemplares similares