Assessment of Coronavirus in the Conjunctival Tears and Secretions in Patients with SARS-CoV-2 Infection in Sohag Province, Egypt

Hany Mahmoud,1 Hatem Ammar,1 Amr El Rashidy,2 Amal H Ali,3 Hesham M Hefny,4 Amr Mounir1 1Sohag Faculty of Medicine, Ophthalmology Department, Sohag University, Sohag, Egypt; 2Tropical Medicine, Sohag Tropical Medicine Hospital, Sohag, Egypt; 3Microbiology and Immunology, Department of Microbiology,...

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Autores principales:	Mahmoud H, Ammar H, El Rashidy A, Ali AH, Hefny HM, Mounir A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	sars-cov-2 conjunctiva conjunctival secretions tears swab (rt‐pcr) Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/164881d15007438da543fc271eda4244
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spelling	oai:doaj.org-article:164881d15007438da543fc271eda42442021-12-02T13:07:03ZAssessment of Coronavirus in the Conjunctival Tears and Secretions in Patients with SARS-CoV-2 Infection in Sohag Province, Egypt1177-5483https://doaj.org/article/164881d15007438da543fc271eda42442020-09-01T00:00:00Zhttps://www.dovepress.com/assessment-of-coronavirus-in-the-conjunctival-tears-and-secretions-in--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Hany Mahmoud,1 Hatem Ammar,1 Amr El Rashidy,2 Amal H Ali,3 Hesham M Hefny,4 Amr Mounir1 1Sohag Faculty of Medicine, Ophthalmology Department, Sohag University, Sohag, Egypt; 2Tropical Medicine, Sohag Tropical Medicine Hospital, Sohag, Egypt; 3Microbiology and Immunology, Department of Microbiology, Aswan University, Aswan, Egypt; 4Clinical Pathology Department, Sohag University, Sohag, EgyptCorrespondence: Amr MounirSohag Faculty of Medicine, Ophthalmology Department, Sohag University, Almohafza Street, Mailbox: 82511, Sohag City, EgyptTel +201005026170Email dramrmonir@yahoo.comPurpose: To assess SARS-CoV-2 virus in conjunctival tears and secretions of positive confirmed COVID-19 patients.Methods: A case series study that included 28 positive COVID-19 patients confirmed with nasopharyngeal swab in the period 18– 28 May 2020 at Sohag Tropical Medicine Hospital. Tears and conjunctival secretions of these confirmed positive cases were collected with disposable sampling swabs at interval of 3 days after admission due to respiratory symptoms. They were examined for the presence of SARS-CoV-2 by reverse transcription-polymerase chain reaction (RT‐PCR) assay.Results: Thirteen (46.43%) patients were stable, 4 (14.28%) patients suffered from dyspnea, 3 (10.72%) patients suffered from high fever, 5 (17.85%) patients suffered from cough, and 3 (10.72%) patients were on mechanical ventilation. Ten (35.71%) patients suffered from conjunctivitis. Tear and conjunctival swabs were positive in 8 (28.57%) patients, while other patients’ swabs were negative (71.43%). Out of 10 patients with conjunctival manifestations, 3 patients had SARS-CoV-2 in their conjunctiva using (RT‐PCR) test. Out of the 18 patients with no conjunctival manifestations, 5 patients had positive SARS-CoV-2 in their conjunctiva using (RT‐PCR) test.Conclusion: The SARS-CoV-2 virus could be found in tears and conjunctival secretions in SARS-CoV-2 patients with or without conjunctivitis.Keywords: SARS-CoV-2, conjunctiva, conjunctival secretions, tears, swab, RT‐PCRMahmoud HAmmar HEl Rashidy AAli AHHefny HMMounir ADove Medical Pressarticlesars-cov-2conjunctivaconjunctival secretionstearsswab(rt‐pcr)OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 2701-2708 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	sars-cov-2 conjunctiva conjunctival secretions tears swab (rt‐pcr) Ophthalmology RE1-994
spellingShingle	sars-cov-2 conjunctiva conjunctival secretions tears swab (rt‐pcr) Ophthalmology RE1-994 Mahmoud H Ammar H El Rashidy A Ali AH Hefny HM Mounir A Assessment of Coronavirus in the Conjunctival Tears and Secretions in Patients with SARS-CoV-2 Infection in Sohag Province, Egypt
description	Hany Mahmoud,1 Hatem Ammar,1 Amr El Rashidy,2 Amal H Ali,3 Hesham M Hefny,4 Amr Mounir1 1Sohag Faculty of Medicine, Ophthalmology Department, Sohag University, Sohag, Egypt; 2Tropical Medicine, Sohag Tropical Medicine Hospital, Sohag, Egypt; 3Microbiology and Immunology, Department of Microbiology, Aswan University, Aswan, Egypt; 4Clinical Pathology Department, Sohag University, Sohag, EgyptCorrespondence: Amr MounirSohag Faculty of Medicine, Ophthalmology Department, Sohag University, Almohafza Street, Mailbox: 82511, Sohag City, EgyptTel +201005026170Email dramrmonir@yahoo.comPurpose: To assess SARS-CoV-2 virus in conjunctival tears and secretions of positive confirmed COVID-19 patients.Methods: A case series study that included 28 positive COVID-19 patients confirmed with nasopharyngeal swab in the period 18– 28 May 2020 at Sohag Tropical Medicine Hospital. Tears and conjunctival secretions of these confirmed positive cases were collected with disposable sampling swabs at interval of 3 days after admission due to respiratory symptoms. They were examined for the presence of SARS-CoV-2 by reverse transcription-polymerase chain reaction (RT‐PCR) assay.Results: Thirteen (46.43%) patients were stable, 4 (14.28%) patients suffered from dyspnea, 3 (10.72%) patients suffered from high fever, 5 (17.85%) patients suffered from cough, and 3 (10.72%) patients were on mechanical ventilation. Ten (35.71%) patients suffered from conjunctivitis. Tear and conjunctival swabs were positive in 8 (28.57%) patients, while other patients’ swabs were negative (71.43%). Out of 10 patients with conjunctival manifestations, 3 patients had SARS-CoV-2 in their conjunctiva using (RT‐PCR) test. Out of the 18 patients with no conjunctival manifestations, 5 patients had positive SARS-CoV-2 in their conjunctiva using (RT‐PCR) test.Conclusion: The SARS-CoV-2 virus could be found in tears and conjunctival secretions in SARS-CoV-2 patients with or without conjunctivitis.Keywords: SARS-CoV-2, conjunctiva, conjunctival secretions, tears, swab, RT‐PCR
format	article
author	Mahmoud H Ammar H El Rashidy A Ali AH Hefny HM Mounir A
author_facet	Mahmoud H Ammar H El Rashidy A Ali AH Hefny HM Mounir A
author_sort	Mahmoud H
title	Assessment of Coronavirus in the Conjunctival Tears and Secretions in Patients with SARS-CoV-2 Infection in Sohag Province, Egypt
title_short	Assessment of Coronavirus in the Conjunctival Tears and Secretions in Patients with SARS-CoV-2 Infection in Sohag Province, Egypt
title_full	Assessment of Coronavirus in the Conjunctival Tears and Secretions in Patients with SARS-CoV-2 Infection in Sohag Province, Egypt
title_fullStr	Assessment of Coronavirus in the Conjunctival Tears and Secretions in Patients with SARS-CoV-2 Infection in Sohag Province, Egypt
title_full_unstemmed	Assessment of Coronavirus in the Conjunctival Tears and Secretions in Patients with SARS-CoV-2 Infection in Sohag Province, Egypt
title_sort	assessment of coronavirus in the conjunctival tears and secretions in patients with sars-cov-2 infection in sohag province, egypt
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/164881d15007438da543fc271eda4244
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Assessment of Coronavirus in the Conjunctival Tears and Secretions in Patients with SARS-CoV-2 Infection in Sohag Province, Egypt

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