High 1-year risk of stroke in patients with hepatocellular carcinoma: a nationwide registry-based cohort study

Abstract Patients with hepatocellular carcinoma (HCC) might be more vulnerable to develop stroke than other cancer patients because of HCC-associated coagulation dysfunction. However, limited studies have investigated the relationship between HCC and stroke. This nationwide population-based cohort s...

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Autores principales:	Jin-Yi Hsu, Peter Pin-Sung Liu, An-Bang Liu, Huei-Kai Huang, Ching-Hui Loh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1649121519734bd881980aeb8c01bb18
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spelling	oai:doaj.org-article:1649121519734bd881980aeb8c01bb182021-12-02T16:51:31ZHigh 1-year risk of stroke in patients with hepatocellular carcinoma: a nationwide registry-based cohort study10.1038/s41598-021-89867-02045-2322https://doaj.org/article/1649121519734bd881980aeb8c01bb182021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89867-0https://doaj.org/toc/2045-2322Abstract Patients with hepatocellular carcinoma (HCC) might be more vulnerable to develop stroke than other cancer patients because of HCC-associated coagulation dysfunction. However, limited studies have investigated the relationship between HCC and stroke. This nationwide population-based cohort study enrolled all patients with HCC diagnosed between 2011 and 2015 from the Taiwan Cancer Registry and Taiwan National Health Insurance Research Database; an age- and sex-matched cohort without cancer was included. The primary outcome was the 1-year risk for first-ever stroke after the index date. The Fine and Gray competing risk regression model was used to estimate the 1-year stroke risk with adjusted hazard ratios (aHRs). After propensity score matching, each cohort has 18,506 patients with similar baseline characteristics. Compared with the cancer-free cohort, the aHRs in the HCC cohort for overall, ischemic, and hemorrhagic strokes were 1.59 [95% confidence interval (CI), 1.35–1.88], 1.38 [95% CI, 1.15–1.65], and 2.62 [95% CI, 1.79–3.84], respectively. On subgroup analysis, HCC patients without cirrhosis, those with stage 3 or 4 cancer had a higher stroke risk than cancer-free cohort. Therefore, stroke prevention should be considered in patients with HCC, especially in those without cirrhosis and with stage 3 or 4 cancer.Jin-Yi HsuPeter Pin-Sung LiuAn-Bang LiuHuei-Kai HuangChing-Hui LohNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jin-Yi Hsu Peter Pin-Sung Liu An-Bang Liu Huei-Kai Huang Ching-Hui Loh High 1-year risk of stroke in patients with hepatocellular carcinoma: a nationwide registry-based cohort study
description	Abstract Patients with hepatocellular carcinoma (HCC) might be more vulnerable to develop stroke than other cancer patients because of HCC-associated coagulation dysfunction. However, limited studies have investigated the relationship between HCC and stroke. This nationwide population-based cohort study enrolled all patients with HCC diagnosed between 2011 and 2015 from the Taiwan Cancer Registry and Taiwan National Health Insurance Research Database; an age- and sex-matched cohort without cancer was included. The primary outcome was the 1-year risk for first-ever stroke after the index date. The Fine and Gray competing risk regression model was used to estimate the 1-year stroke risk with adjusted hazard ratios (aHRs). After propensity score matching, each cohort has 18,506 patients with similar baseline characteristics. Compared with the cancer-free cohort, the aHRs in the HCC cohort for overall, ischemic, and hemorrhagic strokes were 1.59 [95% confidence interval (CI), 1.35–1.88], 1.38 [95% CI, 1.15–1.65], and 2.62 [95% CI, 1.79–3.84], respectively. On subgroup analysis, HCC patients without cirrhosis, those with stage 3 or 4 cancer had a higher stroke risk than cancer-free cohort. Therefore, stroke prevention should be considered in patients with HCC, especially in those without cirrhosis and with stage 3 or 4 cancer.
format	article
author	Jin-Yi Hsu Peter Pin-Sung Liu An-Bang Liu Huei-Kai Huang Ching-Hui Loh
author_facet	Jin-Yi Hsu Peter Pin-Sung Liu An-Bang Liu Huei-Kai Huang Ching-Hui Loh
author_sort	Jin-Yi Hsu
title	High 1-year risk of stroke in patients with hepatocellular carcinoma: a nationwide registry-based cohort study
title_short	High 1-year risk of stroke in patients with hepatocellular carcinoma: a nationwide registry-based cohort study
title_full	High 1-year risk of stroke in patients with hepatocellular carcinoma: a nationwide registry-based cohort study
title_fullStr	High 1-year risk of stroke in patients with hepatocellular carcinoma: a nationwide registry-based cohort study
title_full_unstemmed	High 1-year risk of stroke in patients with hepatocellular carcinoma: a nationwide registry-based cohort study
title_sort	high 1-year risk of stroke in patients with hepatocellular carcinoma: a nationwide registry-based cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1649121519734bd881980aeb8c01bb18
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High 1-year risk of stroke in patients with hepatocellular carcinoma: a nationwide registry-based cohort study

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