Small molecules enhance CRISPR/Cas9-mediated homology-directed genome editing in primary cells

Small molecules enhance CRISPR/Cas9-mediated homology-directed genome editing in primary cells

Abstract CRISPR/Cas9 is an efficient customizable nuclease to generate double-strand breaks (DSBs) in the genome. This process results in knockout of the targeted gene or knock-in of a specific DNA fragment at the targeted locus in the genome of various species. However, efficiency of knock-in media...

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Autores principales: Guoling Li, Xianwei Zhang, Cuili Zhong, Jianxin Mo, Rong Quan, Jie Yang, Dewu Liu, Zicong Li, Huaqiang Yang, Zhenfang Wu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/1649ef17af0144d78c7d0017adcd1333
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