ERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland

<i>ERAS</i> is a relatively uncharacterized gene of the Ras superfamily. It is expressed in ES cells and in the first stages of embryonic development; later on, it is silenced in the majority of cell types and tissues. Although there are several reports showing ERAS expression in tumoral...

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Autores principales:	Cristian Suarez-Cabrera, Isabel Ojeda-Perez, Raquel Sanchez-Baltasar, Angustias Page, Ana Bravo, Manuel Navarro, Angel Ramirez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ERAS transgenic mice Ras pathway breast cancer adenomyoepithelioma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/164c4c4eca474bfaa7a6362328bc4e40
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spelling	oai:doaj.org-article:164c4c4eca474bfaa7a6362328bc4e402021-11-11T15:36:17ZERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland10.3390/cancers132155882072-6694https://doaj.org/article/164c4c4eca474bfaa7a6362328bc4e402021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5588https://doaj.org/toc/2072-6694<i>ERAS</i> is a relatively uncharacterized gene of the Ras superfamily. It is expressed in ES cells and in the first stages of embryonic development; later on, it is silenced in the majority of cell types and tissues. Although there are several reports showing ERAS expression in tumoral cell lines and human tumor samples, it is unknown if ERAS deregulated expression is enough to drive tumor development. In this report, we have generated transgenic mice expressing ERAS in myoepithelial basal cells of the mammary gland and in basal cells of stratified epithelia. In spite of the low level of ERAS expression, these transgenic mice showed phenotypic alterations resembling overgrowth syndromes caused by the activation of the AKT-PI3K pathway. In addition, their mammary glands present developmental and functional disabilities accompanied by morphological and biochemical alterations in the myoepithelial cells. These mice suffer from tumoral transformation in the mammary glands with high incidence. These mammary tumors resemble, both histologically and by the expression of differentiation markers, malignant adenomyoepitheliomas. In sum, our results highlight the importance of <i>ERAS</i> silencing in adult tissues and define a truly oncogenic role for <i>ERAS</i> in mammary gland cells when inappropriately expressed.Cristian Suarez-CabreraIsabel Ojeda-PerezRaquel Sanchez-BaltasarAngustias PageAna BravoManuel NavarroAngel RamirezMDPI AGarticleERAStransgenic miceRas pathwaybreast canceradenomyoepitheliomaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5588, p 5588 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ERAS transgenic mice Ras pathway breast cancer adenomyoepithelioma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	ERAS transgenic mice Ras pathway breast cancer adenomyoepithelioma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cristian Suarez-Cabrera Isabel Ojeda-Perez Raquel Sanchez-Baltasar Angustias Page Ana Bravo Manuel Navarro Angel Ramirez ERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland
description	<i>ERAS</i> is a relatively uncharacterized gene of the Ras superfamily. It is expressed in ES cells and in the first stages of embryonic development; later on, it is silenced in the majority of cell types and tissues. Although there are several reports showing ERAS expression in tumoral cell lines and human tumor samples, it is unknown if ERAS deregulated expression is enough to drive tumor development. In this report, we have generated transgenic mice expressing ERAS in myoepithelial basal cells of the mammary gland and in basal cells of stratified epithelia. In spite of the low level of ERAS expression, these transgenic mice showed phenotypic alterations resembling overgrowth syndromes caused by the activation of the AKT-PI3K pathway. In addition, their mammary glands present developmental and functional disabilities accompanied by morphological and biochemical alterations in the myoepithelial cells. These mice suffer from tumoral transformation in the mammary glands with high incidence. These mammary tumors resemble, both histologically and by the expression of differentiation markers, malignant adenomyoepitheliomas. In sum, our results highlight the importance of <i>ERAS</i> silencing in adult tissues and define a truly oncogenic role for <i>ERAS</i> in mammary gland cells when inappropriately expressed.
format	article
author	Cristian Suarez-Cabrera Isabel Ojeda-Perez Raquel Sanchez-Baltasar Angustias Page Ana Bravo Manuel Navarro Angel Ramirez
author_facet	Cristian Suarez-Cabrera Isabel Ojeda-Perez Raquel Sanchez-Baltasar Angustias Page Ana Bravo Manuel Navarro Angel Ramirez
author_sort	Cristian Suarez-Cabrera
title	ERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland
title_short	ERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland
title_full	ERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland
title_fullStr	ERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland
title_full_unstemmed	ERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland
title_sort	eras, a member of the ras superfamily, acts as an oncoprotein in the mammary gland
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/164c4c4eca474bfaa7a6362328bc4e40
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ERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland

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