Aspirin metabolite sodium salicylate selectively inhibits transcriptional activity of ATF6α and downstream target genes

Abstract In response to ER stress, activating transcription factor 6 (ATF6) traffics from ER to Golgi apparatus where it is activated by cleavage before being translocated as transcription factor to the cell nucleus. In this work we describe ATF6α as a newly target of the aspirin metabolite sodium s...

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Autores principales: Fernanda L. B. Mügge, Aristóbolo M. Silva
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/164de12006754a55bab72c7f91a0b1a6
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