Prevalence and Risk Factors of Restless Legs Syndrome in Hemodialysis Patients

Li-Yan Zhang, 1,* Xiao-Yang Ma, 2,* Jun Lin, 3 Wen-Hu Liu, 4 Wang Guo, 4 Le Yin, 4 Shi-Xiang Wang, 3 Xia Li, 5 Jing Li, 5 Li-Li Jin, 6 Ze-Long Tian, 7 Yi-Tong Du, 1 Hou-Zhen Tuo 1 1Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic...

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Autores principales:	Zhang LY, Ma XY, Lin J, Liu WH, Guo W, Yin L, Wang SX, Li X, Li J, Jin LL, Tian ZL, Du YT, Tuo HZ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	restless legs syndrome hemodialysis prevalence risk factor cardiovascular disease Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/164e2747a0f549d9ba9865e13f26d197
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spelling	oai:doaj.org-article:164e2747a0f549d9ba9865e13f26d1972021-12-02T09:39:38ZPrevalence and Risk Factors of Restless Legs Syndrome in Hemodialysis Patients1179-1608https://doaj.org/article/164e2747a0f549d9ba9865e13f26d1972020-01-01T00:00:00Zhttps://www.dovepress.com/prevalence-and-risk-factors-of-restless-legs-syndrome-in-hemodialysis--peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Li-Yan Zhang, 1,* Xiao-Yang Ma, 2,* Jun Lin, 3 Wen-Hu Liu, 4 Wang Guo, 4 Le Yin, 4 Shi-Xiang Wang, 3 Xia Li, 5 Jing Li, 5 Li-Li Jin, 6 Ze-Long Tian, 7 Yi-Tong Du, 1 Hou-Zhen Tuo 1 1Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Neurology, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 4Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 5Blood Purification Center, Beijing No. 6 Hospital, Beijing, People’s Republic of China; 6Department of Nephrology, Beijing Zhongxing Hospital, Beijing, People’s Republic of China; 7Department of Neurology, Tianjin 4th Central Hospital, Tianjin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hou-Zhen TuoDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong’an Road, Xicheng District, Beijing 100051, People’s Republic of ChinaTel/Fax +86 10-63139807Email tuohzh@sina.cnObjective: The current study aimed to investigate the prevalence and risk factors of restless legs syndrome (RLS) in patients undergoing hemodialysis, as well as the mortality and risks of cardiovascular and cerebrovascular events.Methods: A total of 354 hemodialysis patients from four hospitals were enrolled. RLS was diagnosed using the International RLS Study Group (IRLSSG) criteria. The patients were evaluated face-to-face using the IRLSSG rating scale, Epworth Sleepiness Scale (ESS), Hamilton Anxiety Scale, Hamilton Depression Scale, and Pittsburgh Sleep Quality Index (PSQI). The patients were followed up for 9 months. Death was considered an endpoint event. The cardiovascular and cerebrovascular events were investigated.Results: The prevalence of RLS in hemodialysis patients was 40.7% and was associated with factors such as duration of hemodialysis, hypersensitive C-reactive protein, hyperparathyroidism, glycosylated serum protein, and erythropoietin treatment. The scores of the PSQI, ESS, and Hamilton Depression Scale in the RLS group were significantly higher than those in the non-RLS group (p < 0.05). During follow-ups, the incidence rate of cardiovascular diseases was 18.8% in the RLS group and 8.6% in the non-RLS group (p < 0.005). The IRLSSG rating scores were significantly higher in RLS patients with kidney transplantation failure compared with those without transplantation (p < 0.05).Conclusion: The prevalence of RLS was high in hemodialysis patients. The risk factors of RLS included duration of hemodialysis, hypersensitive C-reactive protein, hyperparathyroidism, glycosylated serum protein, and erythropoietin treatment. RLS affected sleep quality and emotion and increased the risk of cardiovascular diseases in hemodialysis patients. RLS was more severe in patients with kidney transplantation failure compared with those without transplantation.Keywords: restless legs syndrome, hemodialysis, prevalence, risk factor, cardiovascular diseaseZhang LYMa XYLin JLiu WHGuo WYin LWang SXLi XLi JJin LLTian ZLDu YTTuo HZDove Medical Pressarticlerestless legs syndromehemodialysisprevalencerisk factorcardiovascular diseasePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 12, Pp 19-27 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	restless legs syndrome hemodialysis prevalence risk factor cardiovascular disease Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	restless legs syndrome hemodialysis prevalence risk factor cardiovascular disease Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Zhang LY Ma XY Lin J Liu WH Guo W Yin L Wang SX Li X Li J Jin LL Tian ZL Du YT Tuo HZ Prevalence and Risk Factors of Restless Legs Syndrome in Hemodialysis Patients
description	Li-Yan Zhang, 1,* Xiao-Yang Ma, 2,* Jun Lin, 3 Wen-Hu Liu, 4 Wang Guo, 4 Le Yin, 4 Shi-Xiang Wang, 3 Xia Li, 5 Jing Li, 5 Li-Li Jin, 6 Ze-Long Tian, 7 Yi-Tong Du, 1 Hou-Zhen Tuo 1 1Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Neurology, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 4Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 5Blood Purification Center, Beijing No. 6 Hospital, Beijing, People’s Republic of China; 6Department of Nephrology, Beijing Zhongxing Hospital, Beijing, People’s Republic of China; 7Department of Neurology, Tianjin 4th Central Hospital, Tianjin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hou-Zhen TuoDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong’an Road, Xicheng District, Beijing 100051, People’s Republic of ChinaTel/Fax +86 10-63139807Email tuohzh@sina.cnObjective: The current study aimed to investigate the prevalence and risk factors of restless legs syndrome (RLS) in patients undergoing hemodialysis, as well as the mortality and risks of cardiovascular and cerebrovascular events.Methods: A total of 354 hemodialysis patients from four hospitals were enrolled. RLS was diagnosed using the International RLS Study Group (IRLSSG) criteria. The patients were evaluated face-to-face using the IRLSSG rating scale, Epworth Sleepiness Scale (ESS), Hamilton Anxiety Scale, Hamilton Depression Scale, and Pittsburgh Sleep Quality Index (PSQI). The patients were followed up for 9 months. Death was considered an endpoint event. The cardiovascular and cerebrovascular events were investigated.Results: The prevalence of RLS in hemodialysis patients was 40.7% and was associated with factors such as duration of hemodialysis, hypersensitive C-reactive protein, hyperparathyroidism, glycosylated serum protein, and erythropoietin treatment. The scores of the PSQI, ESS, and Hamilton Depression Scale in the RLS group were significantly higher than those in the non-RLS group (p < 0.05). During follow-ups, the incidence rate of cardiovascular diseases was 18.8% in the RLS group and 8.6% in the non-RLS group (p < 0.005). The IRLSSG rating scores were significantly higher in RLS patients with kidney transplantation failure compared with those without transplantation (p < 0.05).Conclusion: The prevalence of RLS was high in hemodialysis patients. The risk factors of RLS included duration of hemodialysis, hypersensitive C-reactive protein, hyperparathyroidism, glycosylated serum protein, and erythropoietin treatment. RLS affected sleep quality and emotion and increased the risk of cardiovascular diseases in hemodialysis patients. RLS was more severe in patients with kidney transplantation failure compared with those without transplantation.Keywords: restless legs syndrome, hemodialysis, prevalence, risk factor, cardiovascular disease
format	article
author	Zhang LY Ma XY Lin J Liu WH Guo W Yin L Wang SX Li X Li J Jin LL Tian ZL Du YT Tuo HZ
author_facet	Zhang LY Ma XY Lin J Liu WH Guo W Yin L Wang SX Li X Li J Jin LL Tian ZL Du YT Tuo HZ
author_sort	Zhang LY
title	Prevalence and Risk Factors of Restless Legs Syndrome in Hemodialysis Patients
title_short	Prevalence and Risk Factors of Restless Legs Syndrome in Hemodialysis Patients
title_full	Prevalence and Risk Factors of Restless Legs Syndrome in Hemodialysis Patients
title_fullStr	Prevalence and Risk Factors of Restless Legs Syndrome in Hemodialysis Patients
title_full_unstemmed	Prevalence and Risk Factors of Restless Legs Syndrome in Hemodialysis Patients
title_sort	prevalence and risk factors of restless legs syndrome in hemodialysis patients
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/164e2747a0f549d9ba9865e13f26d197
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Prevalence and Risk Factors of Restless Legs Syndrome in Hemodialysis Patients

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