Pregnancy outcomes in women affected by fetal alpha-thalassemia: a case control study

Abstract To evaluate the possible associations between fetal α-thalassemia and risk of adverse pregnancy outcomes using a provincial woman-child health service information database in China. This was a case control study (N = 438,747) in which we compared all singleton pregnancies of women with or w...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jiangheng Li, Jingli Yan, Yongquan Huang, Jinlu Wei, Bingyan Xie, Maoling Zhu, Wu Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/164ee11da9434d878c8ab81c87eeef9b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:164ee11da9434d878c8ab81c87eeef9b
record_format	dspace
spelling	oai:doaj.org-article:164ee11da9434d878c8ab81c87eeef9b2021-12-02T16:34:58ZPregnancy outcomes in women affected by fetal alpha-thalassemia: a case control study10.1038/s41598-021-95998-12045-2322https://doaj.org/article/164ee11da9434d878c8ab81c87eeef9b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95998-1https://doaj.org/toc/2045-2322Abstract To evaluate the possible associations between fetal α-thalassemia and risk of adverse pregnancy outcomes using a provincial woman-child health service information database in China. This was a case control study (N = 438,747) in which we compared all singleton pregnancies of women with or without the α-thalassemia trait from May 2016 to May 2020, and where women with the trait were further allocated to a normal fetal group, a group of fetuses with the α-thalassemia trait, and a fetal group with hemoglobin H (HbH) disease according to the results of fetal DNA analysis. With thalassemic women whose fetuses were normal as the reference, fetuses in the HbH disease group showed a higher increase in the odds of Apgar scores being < 7 at 1 min (adjusted odds ratio [aOR], 2.79; 1.03–7.59) and 5 min (aOR, 4.56; 1.07–19.40). With non-thalassemic women as the reference, these trends were more obvious (aOR, 4.83; 2.55–9.16; aOR, 6.24; 2.75–14.18, respectively); whereas the normal fetal group was more likely to be diagnosed with postpartum hemorrhage (aOR, 1.66; 1.10–2.50). In addition, fetal HbH disease and gestational age were two independent factors influencing low Apgar scores, and their combination reflected medium accuracy in Apgar predictions.Jiangheng LiJingli YanYongquan HuangJinlu WeiBingyan XieMaoling ZhuWu JiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiangheng Li Jingli Yan Yongquan Huang Jinlu Wei Bingyan Xie Maoling Zhu Wu Jiang Pregnancy outcomes in women affected by fetal alpha-thalassemia: a case control study
description	Abstract To evaluate the possible associations between fetal α-thalassemia and risk of adverse pregnancy outcomes using a provincial woman-child health service information database in China. This was a case control study (N = 438,747) in which we compared all singleton pregnancies of women with or without the α-thalassemia trait from May 2016 to May 2020, and where women with the trait were further allocated to a normal fetal group, a group of fetuses with the α-thalassemia trait, and a fetal group with hemoglobin H (HbH) disease according to the results of fetal DNA analysis. With thalassemic women whose fetuses were normal as the reference, fetuses in the HbH disease group showed a higher increase in the odds of Apgar scores being < 7 at 1 min (adjusted odds ratio [aOR], 2.79; 1.03–7.59) and 5 min (aOR, 4.56; 1.07–19.40). With non-thalassemic women as the reference, these trends were more obvious (aOR, 4.83; 2.55–9.16; aOR, 6.24; 2.75–14.18, respectively); whereas the normal fetal group was more likely to be diagnosed with postpartum hemorrhage (aOR, 1.66; 1.10–2.50). In addition, fetal HbH disease and gestational age were two independent factors influencing low Apgar scores, and their combination reflected medium accuracy in Apgar predictions.
format	article
author	Jiangheng Li Jingli Yan Yongquan Huang Jinlu Wei Bingyan Xie Maoling Zhu Wu Jiang
author_facet	Jiangheng Li Jingli Yan Yongquan Huang Jinlu Wei Bingyan Xie Maoling Zhu Wu Jiang
author_sort	Jiangheng Li
title	Pregnancy outcomes in women affected by fetal alpha-thalassemia: a case control study
title_short	Pregnancy outcomes in women affected by fetal alpha-thalassemia: a case control study
title_full	Pregnancy outcomes in women affected by fetal alpha-thalassemia: a case control study
title_fullStr	Pregnancy outcomes in women affected by fetal alpha-thalassemia: a case control study
title_full_unstemmed	Pregnancy outcomes in women affected by fetal alpha-thalassemia: a case control study
title_sort	pregnancy outcomes in women affected by fetal alpha-thalassemia: a case control study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/164ee11da9434d878c8ab81c87eeef9b
work_keys_str_mv	AT jianghengli pregnancyoutcomesinwomenaffectedbyfetalalphathalassemiaacasecontrolstudy AT jingliyan pregnancyoutcomesinwomenaffectedbyfetalalphathalassemiaacasecontrolstudy AT yongquanhuang pregnancyoutcomesinwomenaffectedbyfetalalphathalassemiaacasecontrolstudy AT jinluwei pregnancyoutcomesinwomenaffectedbyfetalalphathalassemiaacasecontrolstudy AT bingyanxie pregnancyoutcomesinwomenaffectedbyfetalalphathalassemiaacasecontrolstudy AT maolingzhu pregnancyoutcomesinwomenaffectedbyfetalalphathalassemiaacasecontrolstudy AT wujiang pregnancyoutcomesinwomenaffectedbyfetalalphathalassemiaacasecontrolstudy
_version_	1718383736844713984

Pregnancy outcomes in women affected by fetal alpha-thalassemia: a case control study

Ejemplares similares