Association Between Helicobacter pylori-Negative Peptic Ulcer Disease and Chronic Urticaria: A Retrospective Observational Study

Chengguo Zhang,1 Yinbin Wei2 1Department of Dermatology, Hanchuan People’s Hospital, Hanchuan, 431600, People’s Republic of China; 2Department of Infectious Diseases, Hanchuan People’s Hospital, Hanchuan, 431600, People’s Republic of ChinaCorrespondence: Yinbin WeiDepartment of Infectious Diseases,...

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Autores principales:	Zhang C, Wei Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	chronic urticaria peptic ulcer risk factors helicobacter pylori Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/1654a240446840a49f36eaef95f81d23
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spelling	oai:doaj.org-article:1654a240446840a49f36eaef95f81d232021-11-09T18:40:35ZAssociation Between Helicobacter pylori-Negative Peptic Ulcer Disease and Chronic Urticaria: A Retrospective Observational Study1178-7015https://doaj.org/article/1654a240446840a49f36eaef95f81d232021-11-01T00:00:00Zhttps://www.dovepress.com/association-between-helicobacter-pylori-negative-peptic-ulcer-disease--peer-reviewed-fulltext-article-CCIDhttps://doaj.org/toc/1178-7015Chengguo Zhang,1 Yinbin Wei2 1Department of Dermatology, Hanchuan People’s Hospital, Hanchuan, 431600, People’s Republic of China; 2Department of Infectious Diseases, Hanchuan People’s Hospital, Hanchuan, 431600, People’s Republic of ChinaCorrespondence: Yinbin WeiDepartment of Infectious Diseases, Hanchuan People’s Hospital, No. 1 Renmin Avenue, Hanchuan, 431600, People’s Republic of ChinaEmail weiyinbin1183840@163.comObjective: The association between peptic ulcer disease (PUD) and chronic urticaria (CU) is rarely examined in individuals without Helicobacter pylori infection. The study aimed to investigate the association between Helicobacter pylori-negative PUD and CU.Methods: Patients without Helicobacter pylori infection were retrospectively enrolled from those who visited the clinic or were admitted to the ward of the dermatological department with recent gastroscopy and Helicobacter pylori testing in a tertiary hospital between 2015 and 2019. After categorizing them as patients with and without PUD, we used propensity score matching to identify a cohort of PUD and a control cohort at a ratio of 1:2. CU was determined by examining medical records of the two cohorts, and logistic regression analyses were used to evaluate the association between PUD and CU with or without adjusting for covariates.Results: We included 40 patients with PUD as the PUD cohort and 80 patients without PUD as the control cohort, between which there were no significant differences in patient characteristics, including age, sex, and several comorbidities (P all > 0.05). Among the PUD cohort, 25.00% (10/40) of them were with CU, which was significantly higher than that in the control cohort 8.75% (7/80, P = 0.016). Results of logistic regression analyses showed PUD was significantly associated with increased risk of CU (odds ratio (OR) 3.48, 95% confidence interval (CI) 1.21– 9.99, P = 0.021), which was consistent with that after adjusted for potential confounding factors (OR 3.77, 95% CI 1.24– 11.45, P = 0.019).Conclusion: Helicobacter pylori-negative PUD is associated with increased risk of CU.Keywords: chronic urticaria, peptic ulcer, risk factors, Helicobacter pyloriZhang CWei YDove Medical Pressarticlechronic urticariapeptic ulcerrisk factorshelicobacter pyloriDermatologyRL1-803ENClinical, Cosmetic and Investigational Dermatology, Vol Volume 14, Pp 1637-1643 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic urticaria peptic ulcer risk factors helicobacter pylori Dermatology RL1-803
spellingShingle	chronic urticaria peptic ulcer risk factors helicobacter pylori Dermatology RL1-803 Zhang C Wei Y Association Between Helicobacter pylori-Negative Peptic Ulcer Disease and Chronic Urticaria: A Retrospective Observational Study
description	Chengguo Zhang,1 Yinbin Wei2 1Department of Dermatology, Hanchuan People’s Hospital, Hanchuan, 431600, People’s Republic of China; 2Department of Infectious Diseases, Hanchuan People’s Hospital, Hanchuan, 431600, People’s Republic of ChinaCorrespondence: Yinbin WeiDepartment of Infectious Diseases, Hanchuan People’s Hospital, No. 1 Renmin Avenue, Hanchuan, 431600, People’s Republic of ChinaEmail weiyinbin1183840@163.comObjective: The association between peptic ulcer disease (PUD) and chronic urticaria (CU) is rarely examined in individuals without Helicobacter pylori infection. The study aimed to investigate the association between Helicobacter pylori-negative PUD and CU.Methods: Patients without Helicobacter pylori infection were retrospectively enrolled from those who visited the clinic or were admitted to the ward of the dermatological department with recent gastroscopy and Helicobacter pylori testing in a tertiary hospital between 2015 and 2019. After categorizing them as patients with and without PUD, we used propensity score matching to identify a cohort of PUD and a control cohort at a ratio of 1:2. CU was determined by examining medical records of the two cohorts, and logistic regression analyses were used to evaluate the association between PUD and CU with or without adjusting for covariates.Results: We included 40 patients with PUD as the PUD cohort and 80 patients without PUD as the control cohort, between which there were no significant differences in patient characteristics, including age, sex, and several comorbidities (P all > 0.05). Among the PUD cohort, 25.00% (10/40) of them were with CU, which was significantly higher than that in the control cohort 8.75% (7/80, P = 0.016). Results of logistic regression analyses showed PUD was significantly associated with increased risk of CU (odds ratio (OR) 3.48, 95% confidence interval (CI) 1.21– 9.99, P = 0.021), which was consistent with that after adjusted for potential confounding factors (OR 3.77, 95% CI 1.24– 11.45, P = 0.019).Conclusion: Helicobacter pylori-negative PUD is associated with increased risk of CU.Keywords: chronic urticaria, peptic ulcer, risk factors, Helicobacter pylori
format	article
author	Zhang C Wei Y
author_facet	Zhang C Wei Y
author_sort	Zhang C
title	Association Between Helicobacter pylori-Negative Peptic Ulcer Disease and Chronic Urticaria: A Retrospective Observational Study
title_short	Association Between Helicobacter pylori-Negative Peptic Ulcer Disease and Chronic Urticaria: A Retrospective Observational Study
title_full	Association Between Helicobacter pylori-Negative Peptic Ulcer Disease and Chronic Urticaria: A Retrospective Observational Study
title_fullStr	Association Between Helicobacter pylori-Negative Peptic Ulcer Disease and Chronic Urticaria: A Retrospective Observational Study
title_full_unstemmed	Association Between Helicobacter pylori-Negative Peptic Ulcer Disease and Chronic Urticaria: A Retrospective Observational Study
title_sort	association between helicobacter pylori-negative peptic ulcer disease and chronic urticaria: a retrospective observational study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/1654a240446840a49f36eaef95f81d23
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Association Between Helicobacter pylori-Negative Peptic Ulcer Disease and Chronic Urticaria: A Retrospective Observational Study

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