Changes of deceleration and acceleration capacity of heart rate in patients with acute hemispheric ischemic stroke

Yan-Hong Xu,1 Xing-De Wang,2 Jia-Jun Yang,1 Li Zhou,2 Yong-Chao Pan1 1Department of Neurology, 2Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China Background and purpose: Autonomic dysfunction is comm...

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Autores principales:	Xu YH, Wang XD, Yang JJ, Zhou L, Pan YC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	acute ischemic stroke autonomic dysfunction deceleration capacity of heart rate acceleration capacity of heart rate heart rate variability Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/1654b15615444ba2804eb0d48f4cf3ee
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spelling	oai:doaj.org-article:1654b15615444ba2804eb0d48f4cf3ee2021-12-02T02:40:52ZChanges of deceleration and acceleration capacity of heart rate in patients with acute hemispheric ischemic stroke1178-1998https://doaj.org/article/1654b15615444ba2804eb0d48f4cf3ee2016-03-01T00:00:00Zhttps://www.dovepress.com/changes-of-deceleration-and-acceleration-capacity-of-heart-rate-in-pat-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Yan-Hong Xu,1 Xing-De Wang,2 Jia-Jun Yang,1 Li Zhou,2 Yong-Chao Pan1 1Department of Neurology, 2Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China Background and purpose: Autonomic dysfunction is common after stroke, which is correlated with unfavorable outcome. Phase-rectified signal averaging is a newly developed technique for assessing cardiac autonomic function, by detecting sympathetic and vagal nerve activity separately through calculating acceleration capacity (AC) and deceleration capacity (DC) of heart rate. In this study, we used this technique for the first time to investigate the cardiac autonomic function of patients with acute hemispheric ischemic stroke. Methods: A 24-hour Holter monitoring was performed in 63 patients with first-ever acute ischemic stroke in hemisphere and sinus rhythm, as well as in 50 controls with high risk of stroke. DC, AC, heart rate variability parameters, standard deviation of all normal-to-normal intervals (SDNN), and square root of the mean of the sum of the squares of differences between adjacent normal-to-normal intervals (RMSSD) were calculated. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the severity of stroke. We analyzed the changes of DC, AC, SDNN, and RMSSD and also studied the correlations between these parameters and NIHSS scores. Results: The R–R (R wave to R wave on electrocardiogram) intervals, DC, AC, and SDNN in the cerebral infarction group were lower than those in controls (P=0.003, P=0.002, P=0.006, and P=0.043), but the difference of RMSSD and the D-value and ratio between absolute value of AC (\|AC\|) and DC were not statistically significant compared with those in controls. The DC of the infarction group was significantly correlated with \|AC\|, SDNN, and RMSSD (r=0.857, r=0.619, and r=0.358; P=0.000, P=0.000, and P=0.004). Correlation analysis also showed that DC, \|AC\|, and SDNN were negatively correlated with NIHSS scores (r=-0.279, r=-0.266, and r=-0.319; P=0.027, P=0.035, and P=0.011). Conclusion: Both DC and AC of heart rate decreased in patients with hemispheric infarction, reflecting a decrease in both vagal and sympathetic modulation. Both DC and AC were correlated with the severity of stroke. Keywords: acute ischemic stroke, autonomic dysfunction, deceleration capacity of heart rate, acceleration capacity of heart rate, heart rate variabilityXu YHWang XDYang JJZhou LPan YCDove Medical Pressarticleacute ischemic strokeautonomic dysfunctiondeceleration capacity of heart rateacceleration capacity of heart rateheart rate variabilityGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 293-298 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute ischemic stroke autonomic dysfunction deceleration capacity of heart rate acceleration capacity of heart rate heart rate variability Geriatrics RC952-954.6
spellingShingle	acute ischemic stroke autonomic dysfunction deceleration capacity of heart rate acceleration capacity of heart rate heart rate variability Geriatrics RC952-954.6 Xu YH Wang XD Yang JJ Zhou L Pan YC Changes of deceleration and acceleration capacity of heart rate in patients with acute hemispheric ischemic stroke
description	Yan-Hong Xu,1 Xing-De Wang,2 Jia-Jun Yang,1 Li Zhou,2 Yong-Chao Pan1 1Department of Neurology, 2Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China Background and purpose: Autonomic dysfunction is common after stroke, which is correlated with unfavorable outcome. Phase-rectified signal averaging is a newly developed technique for assessing cardiac autonomic function, by detecting sympathetic and vagal nerve activity separately through calculating acceleration capacity (AC) and deceleration capacity (DC) of heart rate. In this study, we used this technique for the first time to investigate the cardiac autonomic function of patients with acute hemispheric ischemic stroke. Methods: A 24-hour Holter monitoring was performed in 63 patients with first-ever acute ischemic stroke in hemisphere and sinus rhythm, as well as in 50 controls with high risk of stroke. DC, AC, heart rate variability parameters, standard deviation of all normal-to-normal intervals (SDNN), and square root of the mean of the sum of the squares of differences between adjacent normal-to-normal intervals (RMSSD) were calculated. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the severity of stroke. We analyzed the changes of DC, AC, SDNN, and RMSSD and also studied the correlations between these parameters and NIHSS scores. Results: The R–R (R wave to R wave on electrocardiogram) intervals, DC, AC, and SDNN in the cerebral infarction group were lower than those in controls (P=0.003, P=0.002, P=0.006, and P=0.043), but the difference of RMSSD and the D-value and ratio between absolute value of AC (\|AC\|) and DC were not statistically significant compared with those in controls. The DC of the infarction group was significantly correlated with \|AC\|, SDNN, and RMSSD (r=0.857, r=0.619, and r=0.358; P=0.000, P=0.000, and P=0.004). Correlation analysis also showed that DC, \|AC\|, and SDNN were negatively correlated with NIHSS scores (r=-0.279, r=-0.266, and r=-0.319; P=0.027, P=0.035, and P=0.011). Conclusion: Both DC and AC of heart rate decreased in patients with hemispheric infarction, reflecting a decrease in both vagal and sympathetic modulation. Both DC and AC were correlated with the severity of stroke. Keywords: acute ischemic stroke, autonomic dysfunction, deceleration capacity of heart rate, acceleration capacity of heart rate, heart rate variability
format	article
author	Xu YH Wang XD Yang JJ Zhou L Pan YC
author_facet	Xu YH Wang XD Yang JJ Zhou L Pan YC
author_sort	Xu YH
title	Changes of deceleration and acceleration capacity of heart rate in patients with acute hemispheric ischemic stroke
title_short	Changes of deceleration and acceleration capacity of heart rate in patients with acute hemispheric ischemic stroke
title_full	Changes of deceleration and acceleration capacity of heart rate in patients with acute hemispheric ischemic stroke
title_fullStr	Changes of deceleration and acceleration capacity of heart rate in patients with acute hemispheric ischemic stroke
title_full_unstemmed	Changes of deceleration and acceleration capacity of heart rate in patients with acute hemispheric ischemic stroke
title_sort	changes of deceleration and acceleration capacity of heart rate in patients with acute hemispheric ischemic stroke
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/1654b15615444ba2804eb0d48f4cf3ee
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Changes of deceleration and acceleration capacity of heart rate in patients with acute hemispheric ischemic stroke

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