Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival

Skull base chordomas are treated with surgery and chemotherapy but often recur due to incomplete resection, understanding the molecular underpinnings of the tumours may provide additional therapeutic strategies. Here, the authors carry out whole genome sequencing of 80 skull base chordoma tumours an...

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Autores principales:	Jiwei Bai, Jianxin Shi, Chuzhong Li, Shuai Wang, Tongwu Zhang, Xing Hua, Bin Zhu, Hela Koka, Ho-Hsiang Wu, Lei Song, Difei Wang, Mingyi Wang, Weiyin Zhou, Bari J. Ballew, Belynda Hicks, Lisa Mirabello, Dilys M. Parry, Yixuan Zhai, Mingxuan Li, Jiang Du, Junmei Wang, Shuheng Zhang, Qian Liu, Peng Zhao, Songbai Gui, Alisa M. Goldstein, Yazhuo Zhang, Xiaohong R. Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1656ca24aa3f4e03b0ddf0b826f291ea
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spelling	oai:doaj.org-article:1656ca24aa3f4e03b0ddf0b826f291ea2021-12-02T10:44:18ZWhole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival10.1038/s41467-021-21026-52041-1723https://doaj.org/article/1656ca24aa3f4e03b0ddf0b826f291ea2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21026-5https://doaj.org/toc/2041-1723Skull base chordomas are treated with surgery and chemotherapy but often recur due to incomplete resection, understanding the molecular underpinnings of the tumours may provide additional therapeutic strategies. Here, the authors carry out whole genome sequencing of 80 skull base chordoma tumours and identify the SWI/SNF component—PBRM1—as a frequently mutated gene.Jiwei BaiJianxin ShiChuzhong LiShuai WangTongwu ZhangXing HuaBin ZhuHela KokaHo-Hsiang WuLei SongDifei WangMingyi WangWeiyin ZhouBari J. BallewBin ZhuBelynda HicksLisa MirabelloDilys M. ParryYixuan ZhaiMingxuan LiJiang DuJunmei WangShuheng ZhangQian LiuPeng ZhaoSongbai GuiAlisa M. GoldsteinYazhuo ZhangXiaohong R. YangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiwei Bai Jianxin Shi Chuzhong Li Shuai Wang Tongwu Zhang Xing Hua Bin Zhu Hela Koka Ho-Hsiang Wu Lei Song Difei Wang Mingyi Wang Weiyin Zhou Bari J. Ballew Bin Zhu Belynda Hicks Lisa Mirabello Dilys M. Parry Yixuan Zhai Mingxuan Li Jiang Du Junmei Wang Shuheng Zhang Qian Liu Peng Zhao Songbai Gui Alisa M. Goldstein Yazhuo Zhang Xiaohong R. Yang Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival
description	Skull base chordomas are treated with surgery and chemotherapy but often recur due to incomplete resection, understanding the molecular underpinnings of the tumours may provide additional therapeutic strategies. Here, the authors carry out whole genome sequencing of 80 skull base chordoma tumours and identify the SWI/SNF component—PBRM1—as a frequently mutated gene.
format	article
author	Jiwei Bai Jianxin Shi Chuzhong Li Shuai Wang Tongwu Zhang Xing Hua Bin Zhu Hela Koka Ho-Hsiang Wu Lei Song Difei Wang Mingyi Wang Weiyin Zhou Bari J. Ballew Bin Zhu Belynda Hicks Lisa Mirabello Dilys M. Parry Yixuan Zhai Mingxuan Li Jiang Du Junmei Wang Shuheng Zhang Qian Liu Peng Zhao Songbai Gui Alisa M. Goldstein Yazhuo Zhang Xiaohong R. Yang
author_facet	Jiwei Bai Jianxin Shi Chuzhong Li Shuai Wang Tongwu Zhang Xing Hua Bin Zhu Hela Koka Ho-Hsiang Wu Lei Song Difei Wang Mingyi Wang Weiyin Zhou Bari J. Ballew Bin Zhu Belynda Hicks Lisa Mirabello Dilys M. Parry Yixuan Zhai Mingxuan Li Jiang Du Junmei Wang Shuheng Zhang Qian Liu Peng Zhao Songbai Gui Alisa M. Goldstein Yazhuo Zhang Xiaohong R. Yang
author_sort	Jiwei Bai
title	Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival
title_short	Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival
title_full	Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival
title_fullStr	Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival
title_full_unstemmed	Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival
title_sort	whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1656ca24aa3f4e03b0ddf0b826f291ea
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Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival

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